The current status and future perspectives of lactobionic acid production : a review

Abstract

Lactobionic acid is a high value added compound industrially produced through energy intensive chemical synthesis, which uses costly metal catalysts, like gold and platinum. In the next years, biotechnological production of lactobionic acid can be supposed to take the full transition to the manufacturing stage. Productivity of lactobionic acid by microbial production can be affected by various factors-choice of microorganism and its concentration, supply of oxygen, temperature, substrate, cultivation method, pH and aeration rate. The aim was to review research findings for lactobionic acid production as well innovative and efficient technology solutions for self-costs reducing. Whey was recommended as a cheap and suitable substrate for the lactobionic acid production. Whey processing has been advised with Pseudonomas teatrolens in 28 °C and in pH 6 to 7 for yielding the highest productivity. The increasing commercial importance urges the progression of schemes for lactobionic acid biotechnological manufacturing.

Trends in lactose-derived bioactives: synthesis and purification

“…Lactobionic acid is chemically produced by oxidation of the aldehyde group of the glucose moiety of lactose in an energy intensive process [58], so that the enzymatic synthesis with NADP + -dependent glucose-fructose oxidoreductase [59], the cellobiose dehydrogenase/3-HAA-laccase system [60] and the whole cell biosynthesis with Pseudomonas taetrolens [61] have been proposed as more ecofriendly alternatives. Lactobionic acid has several applications in the biomedical field (drug delivery, tissue engineering, organ transplantation) in cosmetics (anti-aging and regenerative skin products), in the chemical industry (surfactant and cobuilder in biodegradable detergents), and in the food sector as a food additive in several products as antioxidant, stabilizer, acidifier, antistaling, mineral absorption enhancer and gelling agent [58]. Beyond this, lactobionic acid share some of the properties of prebiotics by promoting a healthy gut microbiota.…”

Sugar-Based Ionic Liquids: Multifaceted Challenges and Intriguing Potential

“…Lactobionic acid is a disaccharide, derived from the oxidation of lactose, composed of a unit of d -gluconic acid and a unit of β- d -galactose [ 59 ]. Lactobionic acid, like other acidic sugars, represents a valuable platform for synthesizing new ionic liquids through easy, low-cost protocols.…”

Engineered s‐Triazine‐Based Dendrimer‐Honokiol Conjugates as Targeted MMP‐2/9 Inhibitors for Halting Hepatocellular Carcinoma

“…Then, most importantly, the conjugated dendrimers were coupled with liver-specific targeting ligands. Lactobionic acid (LA), a biocompatible [68] targeting ligand that selectively recognizes the asialoglycoprotein receptors overexpressed on HCC, [69,70] was installed on the carboxylic acid-terminated dendrimers, whereas the hydrazide dendrimers were decorated with folic acid (FA) that can bind the HCC overexpressed folate receptors. [70,71] Besides these targeting ligands were selected based on their intrinsic MMP-2/9 inhibitory activities [72][73][74] that will hopefully synergize that of the free dendrimers.…”