The cytidine diphosphate choline content of rat brain

Ansell, G. B.; Bayliss, Brenda J.

doi:10.1042/bj0780209

Cited by 11 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…the paper by Berger and Gimenez [ 5 ], describing crystallization of CDP-choline from yeast) could be qualified as concerning citicoline (the compound synthesized exogenously), but others (e.g. the paper by Ansell and Bayliss [ 6 ], reporting on the concentration of endogenous CDP-choline in the rat brain) undoubtedly concern CDP-choline (the compound synthesized endogenously). The difference between CDP-choline (synthesized endogenously) and citicoline (synthesized exogenously) is not trivial, as will be discussed later.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Properties of Citicoline: Facts, Doubts and Unresolved Issues

Grieb

2014

CNS Drugs

136

View full text Add to dashboard Cite

Citicoline is the generic name of the pharmaceutical substance that chemically is cytidine-5′-diphosphocholine (CDP-choline), which is identical to the natural intracellular precursor of phospholipid phosphatidylcholine. Following injection or ingestion, citicoline is believed to undergo quick hydrolysis and dephosphorylation to yield cytidine and choline, which then enter the brain separately and are used to resynthesize CDP-choline inside brain cells. Neuroprotective activity of citicoline has been repeatedly shown in preclinical models of brain ischaemia and trauma, but two recent, large, pivotal clinical trials have revealed no benefits in ischaemic stroke and traumatic brain injury. However, the substance seems to be beneficial in some slowly advancing neurodegenerative disorders such as glaucoma and mild vascular cognitive impairment. This paper critically discusses issues related to the clinical pharmacology of citicoline, including its pharmacokinetics/biotransformation and pharmacodynamics/mode of action. It is concluded that at present, there is no adequate description of the mechanism(s) of the pharmacological actions of this substance. The possibility should be considered and tested that, in spite of apparently fast catabolism, the intact citicoline molecule or the phosphorylated intermediate products of its hydrolysis, cytidine monophosphate and phosphocholine, are pharmacologically active.

show abstract

Section: Introductionmentioning

confidence: 99%