The Cytological Identity and Interrelation of Mesenchymal Cells of Lymphoid Tissue

Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

“…Subsequently, Volkman and Gowans 133 demonstrated, with the aid of thymidine autoradiography, that these infiltrating macrophages originate from the bone marrow. These new technologies (thymidine autoradiography, immunohistochemistry, parabiosis and electron microscopy) highlighted that the cells of the RES differ in morphology, function and origin 134 .…”

Further Problems of Lymphocyte Production

“…If this is true, it would provide a possible source of replacement for the all-important primitive reticular cell, and the lymphocyte-production pathway might then be regarded as reversible (FIGURE 2 ) . The origin and morphology of the reticular cell have been the subject of a good deal of doubt and speculation (Gall, 1958). In studying regenerating lymphoid tissue, one frequently sees groups of what can be regarded as enlarging small or nledium lymphocytes (cf.…”

Cell receptor studies on seven cases of diffuse histiocytic malignant lymphoma (reticulum cell sarcoma).

“…Gall (1958) proposed that within this group of tumours was a group characterized by the resemblance of tumour cells to histiocytes (macrophages), an entity which he termed 'histiocytic malignant lymphoma' (see review by Stuart, 1974). Lukes (1968) suggested that the neoplastic cells were of lymphoid origin from their morphological resemblance to follicular centre cells.…”

“…In this study an attempt has been made to identify the neoplastic cell population of reticulum cell sarcoma as being either of T or B lymphoid origin as proposed by Lukes, or as being truly histiocytic, ie, macrophage-like, as proposed by Gall (1958).…”