The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry

Huang, Ning; Wu, Mingyi; Zheng, Chang‐Bo; Zhu, Lin; Zhao, Jinhua; Zheng, Yong‐Tang

doi:10.1016/j.carres.2013.07.010

Cited by 72 publications

(54 citation statements)

References 31 publications

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“…Recently, it has been shown that the DHG may also express some antiviral activities, especially against HIV-strains [47,48]. In the work of Lian et al , anti-HIV activities of T. ananas FucCS were assessed by a cytopathic effect assay and in a HIV-1 p24 detection assay [47].…”

Section: Medical Effectsmentioning

confidence: 99%

“…In the work of Huang et al [48], anti-HIV activities of the same T. ananas FucCS were evaluated for its capacity to block laboratory strain HIV-1 IIIB entry and replication (4.26 μg/mL and 0.73 μg/mL, respectively), in inhibiting infection by the clinic isolates HIV-1 KM018 and HIV-1 TC-2 (23.75 μg/mL and 31.86 μg/mL, respectively), and for suppressing HIV-1 drug-resistant virus [48]. From this reference, it has been shown that FucCS can also inhibit HIV-2 ROD and HIV-2 CBL-20 replication (100 μg/mL).…”

Section: Medical Effectsmentioning

confidence: 99%

“…Further analyses have indicated that FucCS can potently bind to the recombinant HIV-1 gp120 protein, but no inhibition of recombinant HIV-1 reverse transcriptase was observed. From the work of Huang et al [48], FucCS was shown to be capable of inhibiting several strains of HIV-1 replication with different levels of response. These results have suggested that FucCS may possess great potential to be further developed as novel HIV-1 entry inhibitor for treatment of HIV/AIDS patients, particularly for those infected by T-20-resistant variants.…”

Section: Medical Effectsmentioning

confidence: 99%

“…These results have suggested that FucCS may possess great potential to be further developed as novel HIV-1 entry inhibitor for treatment of HIV/AIDS patients, particularly for those infected by T-20-resistant variants. These two recent publications from Chinese scientists strongly support the development of new anti-HIV drugs from marine invertebrate sources [47,48]. …”

Section: Medical Effectsmentioning

confidence: 99%

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Holothurian Fucosylated Chondroitin Sulfate

2014

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Fucosylated chondroitin sulfate (FucCS) is a structurally distinct glycosaminoglycan found in sea cucumber species. It has the same backbone composition of alternating 4-linked glucuronic acid and 3-linked N-acetyl galactosamine residues within disaccharide repeating units as regularly found in mammalian chondroitin sulfates. However, FucCS has also sulfated fucosyl branching units 3-O-linked to the acid residues. The sulfation patterns of these branches vary accordingly with holothurian species and account for different biological actions and responses. FucCSs may exhibit anticoagulant, antithrombotic, anti-inflammatory, anticancer, antiviral, and pro-angiogenic activities, besides its beneficial effects in hemodialysis, cellular growth modulation, fibrosis and hyperglycemia. Through an historical overview, this document covers most of the science regarding the holothurian FucCS. Both structural and medical properties of this unique GAG, investigated during the last 25 years, are systematically discussed herein.

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Section: Medical Effectsmentioning

confidence: 99%

Section: Medical Effectsmentioning

confidence: 99%

Section: Medical Effectsmentioning

confidence: 99%

Section: Medical Effectsmentioning

confidence: 99%

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Holothurian Fucosylated Chondroitin Sulfate

2014

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“…The current research on bioactivities of SC-CHS is mainly focused on anticoagulation (Yang, Wang, Jiang, & Lv, 2015), antithrombosis (Chen et al, 2012), inhibition on adipogenesis , and inhibition on HIV replication (Huang et al, 2013). Pharmacokinetic studies performed on humans have demonstrated that CHS from other species can be absorbed by an oral route (Cho et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Fucosylated chondroitin sulphate from sea cucumber reduces hepatic endoplasmic reticulum stress-associated inflammation in obesity mice

Jiang

et al. 2015

Journal of Functional Foods

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Synthesis of Fucosylated Chondroitin Sulfate Glycoclusters: A Robust Route to New Anticoagulant Agents

Zhang

Yao

et al. 2017

Chemistry A European J

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Fucosylated chondroitin sulfate (FuCS) is a structurally distinct glycosaminoglycan with excellent anticoagulant activity. Studies show that FuCS and its depolymerized fragments exhibit a different anticoagulant mechanism from that of heparin derivatives, with decreased risks of adverse effects and bleeding. However, further exploitation has been hindered by the scarcity of structurally defined oligosaccharides. Herein, facile method is reported for the synthesis of the repeating trisaccharide unit of FuCS based on the degradation of chondroitin sulfate polymers. A series of simplified FuCS glycomimetics that have highly tunable structures, controllable branches, and defined sulfation motifs were generated by copper-catalyzed alkyne-azide cycloaddition. Remarkable improvement in activated partial thromboplastin time (APTT) assay activities was observed as the branches increased, but no significant influences were observed for prothrombin time (PT) and thrombin time (TT) assay activities. Further FXase inhibition tests suggested that glycoclusters 33 b-40 b selectively inhibited intrinsic anticoagulant activities, but had little effect on the extrinsic and common coagulation pathways. Notably, glycoclusters with the 2,4-di-O-sulfated fucosyl residue displayed the most potency, which was in consistent with that of natural polysaccharides. These FuCS clusters demonstrated potency to mimic linear glycosaminoglycans and offer a new framework for the development of novel anticoagulant agents.

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The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry

Cited by 72 publications

References 31 publications

Holothurian Fucosylated Chondroitin Sulfate

Holothurian Fucosylated Chondroitin Sulfate

Fucosylated chondroitin sulphate from sea cucumber reduces hepatic endoplasmic reticulum stress-associated inflammation in obesity mice

Synthesis of Fucosylated Chondroitin Sulfate Glycoclusters: A Robust Route to New Anticoagulant Agents

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