The design, rationale, and baseline characteristics of a nationwide cohort registry in China: blood pressure and clinical outcome in TIA or ischemic stroke

Abstract

BackgroundThe relationship between poststroke blood pressure (BP) and clinical outcomes in ischemic stroke (IS) is still controversial. However, there is no large BP database for IS or transient ischemic attack (TIA) in China. This study aims to describe the rationale, study design, and baseline characteristics of a nationwide BP database in IS or TIA patients in China.Materials and methodsThe BOSS (blood pressure and clinical outcome in TIA or ischemic stroke) study was a hospital-based, prospective cohort study aiming to assess BP parameters and clinical outcome in IS/TIA patients. BP parameters were based on office BP, ambulatory BP, and home BP. Clinical outcomes included stroke recurrence, combined vascular events, and disability. Electronic case-report forms were used to record baseline and follow-up data. The patients were followed up for clinical outcomes at 3 months through face-to-face interview and at 12 months by telephone.ResultsBetween October 2012 and February 2014, the BOSS registry recruited 2,608 patients from 61 hospitals, with a mean age of 62.5 years, 32.4% of whom were female, 88.9% with an entry diagnosis of IS, and 86% diagnosed with hypertension. The rates of patients lost-to-follow-up were 3.1% at 3 months and 5.1% at 1 year; 93% of patients completed ambulatory BP monitoring during hospitalization and 94.7% finished a 3-month BP diary.ConclusionThe BOSS registry will provide important evidence about BP management in the acute phase and secondary prevention for IS/TIA patients.

Acute‐phase blood pressure trajectories and clinical outcomes in ischemic stroke

“…The BOSS, a hospital‐based, prospective cohort study, focuses on characteristics of office BP, ambulatory BP, and home BP within 7 days after onset of IS and transient ischemic attack (TIA), and their associations with clinical outcomes. The study design of the BOSS registry has been described elsewhere . Briefly, 2608 patients with IS and TIA were recruited between October 2012 and February 2014 in 61 hospitals in China, with 1448 patients hospitalized within 24 hours after stroke onset and followed for clinical outcomes for 3 months by personal interview.…”

“…The study design of the BOSS registry has been described elsewhere. 13 Briefly, 2608 patients with IS and TIA were recruited between October 2012 and February 2014 in 61 hospitals in China, with 1448 patients hospitalized within 24 hours after stroke onset and followed for clinical outcomes for 3 months by personal interview. Acute IS was diagnosed according to World Health Organization criteria combined with brain computed tomography or magnetic resonance imaging confirmation.…”

Assessing the applicability of 2017 ACC/AHA hypertension guidelines for secondary stroke prevention in the BOSS study

“…The BOSS study enrolled 2,608 participants from 61 hospitals in China between 2012 and 2014. The study design and recruitment details have been described previously . All participants met the following inclusion criteria: age of 18 years or older, diagnosed with acute IS or TIA, and within seven days of the index event.…”

“…The study design and recruitment details have been described previously. 7 All participants met the following inclusion criteria: age of 18 years or older, diagnosed with acute IS or TIA, and within seven days of the index event. Written informed consent was obtained from all study participants.…”

The J-curve Association between Systolic Blood Pressure and Clinical Outcomes in Ischemic Stroke or TIA: The BOSS Study

“…This study was conducted among patients from the BOSS study, a nationwide, hospital-based, longitudinal cohort. The design of the BOSS study has been described in detail elsewhere 18 . Briefly, 2608 patients from 61 hospitals were recruited between October 2012 and February 2014, aimed to assess BP parameters and clinical outcomes in IS/TIA patients.…”