The detection of bone marrow involvement in small-cell lung cancer using magnetic resonance imaging.

Bone marrow metastases in small cell lung cancer: detection with magnetic resonance imaging and monoclonal antibodies

“…Two MoABs of the immunoglobulin (Ig) G isotype (UJ 13 A kindly provided by J. Kemshead,11.14 kindly provided by J.C. Laurent, SANOFI) recognise antigens expressed by cells of neuroectodermal origin (Favrot et al, 1986;Rosier & Laurent, 1987), and CD45 of the IgM isotype (kindly provided by G. Janossy) recognises the panleucocyte antigen (Kemshead et al, 1983;Maritaz et al, 1988 MR examinations were considered to be positive or negative depending on the presence or absence of focal areas of low signal intensity within an area of normal signal intensity corresponding to marrow fat, as already described in malignant lymphoma (Shields et al, 1987) and in SCLC (Trillet et al. 1988 These results are consistent with the conclusions of Hirsch and co-workers (Hirsch et al, 1977) on a group of 203 SCLC patients where BM aspiration was shown to be more effective than BM biopsy in detecting BM metastases in SCLC.…”