The developing role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles

Ortiz, Geovanny Genaro Reiván; Zaidi, Neelam Hazoor; Saini, Ravinder Singh; Coronel, Andrés Alexis Ramírez; Alsandook, Tahani; Lafta, Methaq Hadi; Arias-Gonzáles, José Luis; Amin, Ali H.; Maaliw, Renato R.

doi:10.1016/j.intimp.2023.110531

Cited by 13 publications

(4 citation statements)

References 198 publications

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“…They are capable of multilineage differentiation that can be directed to the mesodermal lineage cells (such as adipocytes, osteocytes, and chondrocytes) and ectodermal lineage cells (neuronal and neuroglial cells) [ 42 ]. Furthermore, this type of stem cell has demonstrated adherence during growth, self-renewable capability, pluripotency, and immunomodulatory properties [ 43 ]. Such qualities make MSCs widely used in cell therapy, tissue engineering, and regenerative medicine.…”

Section: Evs As Therapeutic Agents In Ibdmentioning

confidence: 99%

“…These components allow membrane fusion with target cells [ 48 ]. Moreover, EVs have similar immunomodulatory roles as their source cells because they contain many of the same cytoplasmatic proteins and metabolic molecules, including deoxyribonucleic acid (DNA), mRNA, miRNA, signaling lipids, proteins, and soluble factors such as cytokines, chemokines, and growth factors [ 43 ]. Basically, they have shown the same therapeutic efficacy and have been recognized as potential candidates for treating autoimmune diseases.…”

Section: Evs As Therapeutic Agents In Ibdmentioning

confidence: 99%

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Extracellular Vesicles: Novel Potential Therapeutic Agents in Inflammatory Bowel Diseases

Mignini,

Piccirilli,

Termite

et al. 2023

Cells

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Patients affected by inflammatory bowel diseases (IBD) can nowadays benefit from a growing number of pharmacological options. However, in moderate-to-severe cases, the therapeutic response is still far from optimal, and treatment changes and optimizations are often required. Thus, researchers in this field are strongly engaged in studies aiming to identify new potential therapeutic targets. Extracellular vesicles (EVs) are tiny subcellular bodies with a phospholipid bilayer envelope containing bioactive molecules, which are released from different cells and are involved in intercellular communication. Recent pre-clinical data show their emerging role in the pathogenesis and treatment of IBD. In our review, we summarize current evidence about the function of EVs as active therapeutic agents in ulcerative colitis and Crohn’s disease, analyzing the properties of EVs derived from different cellular sources and the mechanisms through which they may improve intestinal inflammation.

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Section: Evs As Therapeutic Agents In Ibdmentioning

confidence: 99%

Section: Evs As Therapeutic Agents In Ibdmentioning

confidence: 99%

Extracellular Vesicles: Novel Potential Therapeutic Agents in Inflammatory Bowel Diseases

Mignini,

Piccirilli,

Termite

et al. 2023

Cells

View full text Add to dashboard Cite

show abstract

“…Stem cells possess the ability to secrete a wide range of regenerative cytokines, and these cellular secretions have been proposed to contribute to the positive therapeutic effects observed in different diseases [68][69][70]. Extracellular vesicles (EVs) are an important component of these secretions that have cytoprotective, antiapoptotic, and angiogenic effects on injured tissues and can promote progenitor and stem cell homing [71].…”

Section: Stem-cell-derived Extracellular Vesiclesmentioning

confidence: 99%

An Update on Experimental Therapeutic Strategies for Thin Endometrium

Tang,

Frisendahl,

Lalitkumar

et al. 2023

Endocrines

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Infertility caused by a thin endometrium remains a significant challenge in assisted reproduction and is often associated with a low success rate after treatment with assisted reproductive technology. There is a lack of consensus in the field concerning both its diagnostic criteria and clinical management. The currently available treatment options are few with limited efficacy. Recent advances in cell therapy and bioengineering have, however, shown promising results for the treatment of a thin endometrium. Notably, these novel interventions have demonstrated the ability to increase endometrial thickness, restore endometrial function, and improve reproductive outcomes. In this comprehensive review, we focus on a critical evaluation of these emerging therapeutic strategies for a thin endometrium including platelet-rich plasma, exosomes derived from stem cells, and bioengineering-based techniques. By synthesizing the findings from available clinical trials, we highlight the promising outcomes achieved so far and underscore the importance of robust clinical trials in assessing the safety and efficacy of these interventions in the future. Continued research efforts to unravel the intricate mechanisms involved in endometrial repair and regeneration will also be essential to enhance our understanding of this multifactorial condition and to identify novel treatment targets for future therapeutic interventions.

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“…Mesenchymal stem cells (MSCs) are cells present in many tissues and are versatile nonhematopoietic adult cells that can be differentiated into multiple cell types [ 14 ]. MSCs can be obtained from a patient’s own tissue, such as adipose tissue, bone marrow, dental pulp, and the umbilical cord [ 8 , 15 , 16 , 17 , 18 ]. The use of MSCs as therapy for stroke would limit immune reactions.…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Effects of Blueberry-Treated Stem Cell-Derived Extracellular Vesicles in Ischemic Stroke

Jang,

Yu,

Kim

et al. 2024

IJMS

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An ischemic stroke, one of the leading causes of morbidity and mortality, is caused by ischemia and hemorrhage resulting in impeded blood supply to the brain. According to many studies, blueberries have been shown to have a therapeutic effect in a variety of diseases. Therefore, in this study, we investigated whether blueberry-treated mesenchymal stem cell (MSC)-derived extracellular vesicles (B-EVs) have therapeutic effects in in vitro and in vivo stroke models. We isolated the extracellular vesicles using cryo-TEM and characterized the particles and concentrations using NTA. MSC-derived extracellular vesicles (A-EVs) and B-EVs were round with a lipid bilayer structure and a diameter of ~150 nm. In addition, A-EVs and B-EVs were shown to affect angiogenesis, cell cycle, differentiation, DNA repair, inflammation, and neurogenesis following KEGG pathway and GO analyses. We investigated the protective effects of A-EVs and B-EVs against neuronal cell death in oxygen–glucose deprivation (OGD) cells and a middle cerebral artery occlusion (MCAo) animal model. The results showed that the cell viability was increased with EV treatment in HT22 cells. In the animal, the size of the cerebral infarction was decreased, and the behavioral assessment was improved with EV injections. The levels of NeuN and neurofilament heavy chain (NFH)-positive cells were also increased with EV treatment yet decreased in the MCAo group. In addition, the number of apoptotic cells was decreased with EV treatment compared with ischemic animals following TUNEL and Bax/Bcl-2 staining. These data suggested that EVs, especially B-EVs, had a therapeutic effect and could reduce apoptotic cell death after ischemic injury.

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The developing role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles

Cited by 13 publications

References 198 publications

Extracellular Vesicles: Novel Potential Therapeutic Agents in Inflammatory Bowel Diseases

Extracellular Vesicles: Novel Potential Therapeutic Agents in Inflammatory Bowel Diseases

An Update on Experimental Therapeutic Strategies for Thin Endometrium

The Therapeutic Effects of Blueberry-Treated Stem Cell-Derived Extracellular Vesicles in Ischemic Stroke

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