The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review

Fontana, Bárbara D.; Mezzomo, Nathana J.; Kalueff, Allan V.; Rosemberg, Denis B.

doi:10.1016/j.expneurol.2017.10.004

Cited by 211 publications

(115 citation statements)

References 301 publications

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“…Zebrafish have been used to study the ontogeny of the DA system 5,6 and is an important vertebrate model to study human diseases and neuropsychiatric conditions. 7,8 Characterization of the DA system can include the investigation of genes involved in DA synthesis, transport and signal transduction. Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in DA biosynthesis (converting tyrosine to L-DOPA) in catecholamine production.…”

Section: Funding Informationmentioning

confidence: 99%

“…The zebrafish ( Danio rerio ) (ZF) has emerged as a useful model for developmental neuroscience. Zebrafish have been used to study the ontogeny of the DA system and is an important vertebrate model to study human diseases and neuropsychiatric conditions . Characterization of the DA system can include the investigation of genes involved in DA synthesis, transport and signal transduction.…”

Section: Introductionmentioning

confidence: 99%

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Domperidone upregulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio)

Shontz

Souders

Schmidt

et al. 2018

Genes Brain and Behavior

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Dopamine (DA) plays a significant role in cognition, motor function and social behavior. The objectives of this study were to (1) quantify the temporal expression of transcripts (DA receptors, transporters and tyrosine hydroxylase) associated with DA signaling during early stages of zebrafish development and (2) determine their expression profiles following treatment with a D receptor antagonist domperidone (DMP). We also assessed locomotor behavior following treatment with DMP using alternating periods of light and dark (ie, dark photokinesis), as DA plays a key role in behavior. Relative expression levels of transcripts that were investigated and related to the DA system were detected after the first 24 hours postfertilization (hpf). Some DA receptor transcripts (eg, drd4c) increased in abundance earlier in the embryo compared with other receptors (eg, drd3), suggesting that DA receptor paralogs may have unique roles in development. Treatment of larvae with DMP resulted in the upregulation of DA receptor transcripts (ie, drd1, drd7, drd4b, drd4c) and DA transporter 1 (ie, slc6a3), and it is hypothesized that upregulation of genes related to the DA system is a compensatory neurophysiological response to DA receptor antagonism. Larval activity during dark photokinesis (measured by distance traveled) was also elevated by DMP. We hypothesize that behavioral responses observed with DMP may be related to the regulation of deep brain photoreception in zebrafish (Danio rerio) (ZF) larvae by DA.

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Section: Funding Informationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Domperidone upregulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio)

Shontz

Souders

Schmidt

et al. 2018

Genes Brain and Behavior

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“…Zebrafish ( Danio rerio ) is a versatile vertebrate model system that has been widely used in translational neuropsychiatric research (Fontana et al 2018; Stewart et al 2015) and to understand evolutionary aspects of animal cognition (Oliveira 2013; Reale et al 2007). The last decade has seen an increase in the use of zebrafish to study the mechanisms underlying lateralization (Andersson et al 2015; Ariyomo and Watt 2013; Barth et al 2005; Dadda et al 2010a; Sovrano and Andrew 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Zebrafish (Danio rerio ) is a versatile vertebrate model system that has been widely used in translational neuropsychiatric research (Fontana et al 2018; Stewart et al 2015). The promise of zebrafish as an alternative organism for modeling human disorders is based on their conserved genome (Barbazuk et al 2000; Howe et al 2013; MacRae and Peterson 2015) and well-characterized physiology (Holzschuh et al 2001; MacRae and Peterson 2015; Rico et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

Fontana

Clay

Parker

2019

Preprint

Self Cite

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6Once considered a uniquely human attribute, behavioral laterality has proven to be 3 7 ubiquitous among non human animals, being frequently associated with different 3 8 neurophenotypes in rodents and fish species. Zebrafish (Danio rerio) are a versatile vertebrate 3 9 model system that has been widely used in translational neuropsychiatric research due their 4 0 highly conserved genetic homology, well characterized physiological and extensive behavioral 4 1 repertoire. Although the spontaneous left-and right-bias responses and associated behavioral 4 2 domains (e.g. stress reactivity, aggression and learning) have previously been observed in other 4 3 teleost species, no information regarding how spontaneous motor left-right bias responses of 4 4 zebrafish predicts other behavioral domains has been described. Thus, we aimed to investigate 4 5 the existence and incidence of natural left-right bias of adult zebrafish in the Y-maze test and 4 6 explore any relationship of biasedness on the performance of different behavioral domains. This 4 7 included learning about threat-cues in the fear conditioning test and locomotion and anxiety-4 8related behavior in the novel tank diving test. In conclusion, we showed for the first time that 4 9 handling in a single day (see Fig. 1). During the pair-housing period, animals had shared

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“…Danio rerio (zebrafish) have become an organism model widely used for studies related to normal or altered human behavior. It is justified since this specie presents a high degree of genetic, biochemical and histological homology to humans [5][6][7][8][9][10] . Zebrafish neurophysiology and behavior are regulated by the same neurotransmitter systems that are described in mammals, including humans.…”

mentioning

confidence: 99%

Acute Restraint Stress Evokes Anxiety-Like Behavior Mediated by Telencephalic Inactivation and GabAergic Dysfunction in Zebrafish Brains

Assad

Luz

Santos-Silva

et al. 2020

Sci Rep

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Acute stress is an important factor in the development of anxiety disorders. Zebrafish are an organism model widely used by studies that aim to describe the events in the brain that control stress-elicited anxiety. the goal of the current study was to evaluate the pattern of cell activation in the telencephalon of adult zebrafish and the role of the GABAergic system on the modulation of anxiety-like behavior evoked by acute restraint stress. Zebrafish that underwent acute restraint stress presented decreased expression of the c-fos protein in their telencephalon as well as a significant decrease in GABA release. The data also supports that decreased GABA levels in zebrafish brains have diminished the activation of GABAA receptors eliciting anxiety-like behavior. Taken together these findings have helped clarify a neurochemical pathway controlling anxiety-like behavior evoked by acute stress in zebrafish while also opening the possibility of new perspective opportunities to use zebrafish as an animal model to test anxyolitic drugs that target the GABAergic system. open Scientific RepoRtS | (2020) 10:5551 | https://doi.

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The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review

Cited by 211 publications

References 301 publications

Domperidone upregulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio)

Domperidone upregulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio)

Zebrafish (Danio rerio) behavioral laterality predicts increased short-term avoidance memory but not stress-reactivity responses

Acute Restraint Stress Evokes Anxiety-Like Behavior Mediated by Telencephalic Inactivation and GabAergic Dysfunction in Zebrafish Brains

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