The Development and Characterization of a pH Dependent Matrix Tablet Containing Probiotics

Abstract

The objective of this study was to develop a pH dependent oral matrix tablet containing probiotics. In this study, hydroxyl-propyl-methyl-cellulose (HPMC) and polyvinyl pyrrolidone K30 (PVP K-30) was utilized as a binder, sodium starch glycolate (SSG) was used as a disintegrant material for the tablet formulation. The disintegration test, hardness test, angle of response were performed to examine the characteristics of prepared tablet. Lactobacillus vitality test was applied to analyze the total Lactobacillus viable count. The results demonstrated that the pH dependent matrix tablet was prepared successfully and can thus be industrialized instead of the current methodologies used for preparation of conventional probiotics. Fuller, 1991;Kim and Gilliland, 1983;McFarland et al., 1995;Hove et al., 1999;Nguyen et al., 2007).