The development of a sensitive methodology to characterise hard shell capsule puncture by dry powder inhaler pins

Torrisi, Barbara M.; Birchall, James Caradoc; Jones, B.E.; Dı́ez, Fernando V.; Coulman, Sion

doi:10.1016/j.ijpharm.2013.08.011

Cited by 13 publications

(19 citation statements)

References 6 publications

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“…The dosage form of DPIs is usually a capsule, which must be punctured with sharpened pins to release the powders 49 . Laryngeal administration of powders are inhaled through the oral cavity, and the suction of powders from the mouth is the first step.…”

Section: Methodsmentioning

confidence: 99%

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Zhao

Guo

Wang

et al. 2020

Acta Pharmaceutica Sinica B

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It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases. When the inhalable micron-sized crystals of γ -cyclodextrin metal-organic framework (CD-MOF) was utilized as dry powder inhalers (DPIs) carrier with high fine particle fraction (FPF), it was found in this research that the encapsulation of a glycoside compound, namely, scutellarin (SCU) in CD-MOF could significantly enhance its laryngeal deposition. Firstly, SCU loading into CD-MOF was optimized by incubation. Then, a series of characterizations were carried out to elucidate the mechanisms of drug loading. Finally, the laryngeal deposition rate of CD-MOF was 57.72 ± 2.19% improved by SCU, about two times higher than that of CD-MOF, when it was determined by Next Generation Impactor (NGI) at 65 L/min. As a proof of concept, pharyngolaryngitis therapeutic agent dexamethasone (DEX) had improved laryngeal deposition after being co-encapsulated with SCU in CD-MOF. The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF, which defined the enhanced laryngeal anchoring. In conclusion, the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.

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Section: Methodsmentioning

confidence: 99%

Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery

Zhao

Guo

Wang

et al. 2020

Acta Pharmaceutica Sinica B

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“…For a capsule-based DPI, an essential requirement is that the capsule should be punctured easily without being broken into fragments which could have been inhaled. Since, HPMC can tolerate extreme deviations in environmental humidity, it is resistant to breakage and clean puncture is produced by the inhaler device without fragmentation and also does not shrink when kept at low humidity environment [30][31][32]. In order to have favourable drug delivery from device, the HPMC capsule for inhalation usually contains slightly higher percentage of moisture.…”

Section: Effect Of Fill Materials On Hpmc Capsule Shell Stabilitymentioning

confidence: 99%

HPMC as Capsule Shell Material: Physicochemical, Pharmaceutical and Biopharmaceutical Properties

Majee¹,

Avlani²,

Biswas³

2017

Int J Pharm Pharm Sci

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The most common instability problem of gelatin capsules arises from negative impact of extremes of temperature and especially atmospheric relative humidity on the mechanical integrity of the capsule shells with adverse effect extended even to the fill material. Moreover, choice of fill materials is highly restricted either due to their specific chemical structure, physical state or hygroscopicity. Additional reports of unpredictable disintegration and dissolution of filled hard gelatin capsules in experimental studies have prompted the search for a better alternative capsule shell material. The present review aims to provide an overview on the physicochemical, pharmaceutical and biopharmaceutical properties of hydroxypropyl methylcellulose (HPMC) as capsule shell material and perform comparative evaluation of HPMC and gelatin in terms of in vitro/in vivo performance and storage stability. HPMC capsule provides a highly flexible and widely acceptable platform capable of solving numerous challenges currently facing the pharmaceutical and nutraceutical industries and expands the possibilities for selection of different types of fill materials. The current topic introduces a new section on influence of various factors on in vitro dissolution of HPMC capsules. Delayed in vitro disintegration/dissolution of HPMC capsules in aqueous medium does not produce any negative effect in vivo. However, advancements in the processes of production and filling of HPMC capsule shells and detailed studies on effects of various parameters on their in vitro/in vivo dissolution would establish their supremacy over hard gelatin capsules in future.

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“…The capsule-based unit-dose DPI device is not preloaded with the capsule by the manufacturer. The patient breaks the presealed aluminum foil package, removes the prefilled capsule, loads the device and presses the button that pierces or cuts the capsule with pins or blade to release the formulation upon inhalation [55,100]. The capsule opening (piercing/cutting) offers the initial de-agglomeration and turbulence within the capsule.…”

Section: Metering Systemmentioning

confidence: 99%

“…On further force from the pins, capsule puncture occurs after which the force reduces and the pin progressively proceeds into the capsule. Capsule puncture tends to be easier at lower humidity (11%) than higher [100]. Emptying of the powder depends on the number and diameter of holes made in the capsule [64].…”

Section: Metering Systemmentioning

confidence: 99%