The development of hypercalcemia in a patient with an ovarian tumor producing parathyroid hormone-related protein

Fujino, Toshinori; Watanabe, Tomoko; Yamaguchi, Ken; Nagasaki, Koichi; Onishi, Eishi; Iwamoto, Ichiro; Dozono, H; Nagata, Yukihiro

doi:10.1002/1097-0142(19921215)70:12<2845::aid-cncr2820701221>3.0.co;2-f

Cited by 25 publications

(9 citation statements)

References 17 publications

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“…These findings suggest that the secretion of PTH‐rP from the uterine tumor was the predominant factor in the hypercalcemia. In regard to gynecologic malignant neoplasms producing PTH‐rP, various kinds of ovarian tumors have been reported 12,22 . However, in the uterus, the only tumors associated with PTH‐rP secretion were carcinomas 23,24 .…”

Section: Discussionmentioning

confidence: 99%

Uterine tumors resembling ovarian sex‐cord tumors producing parathyroid hormone‐related protein of the uterine cervix

Suzuki

Matsumoto

Fukunaga

et al. 2002

Pathology International

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A case of uterine tumors resembling ovarian sex-cord tumors (UTROSCT) producing parathyroid hormone-related protein (PTH-rP) of the uterine cervix is reported. A 66-year-old woman underwent total hysterectomy with bilateral salpingo -oophorectomy due to the possibility of a malignant uterine tumor. A fairly well-circumscribed tumor, measuring 8 x 5 x 7 cm, was present in the myometrium of the cervix and extended into the endocervical mucosa. Histologically, the tumor showed predominantly sex-cord-like differentiation and the features of conventional endometrial low-grade stromal sarcoma were observed in part. Immunohistochemically, the tumor cells were negative for CD10. From these findings, we diagnosed the present case as Clement and Scully's group II UTROSCT arising from the uterine cervix. To our knowledge, this is the first report of the cervical occurrence of UTROSCT. Furthermore, in this tumor, production of PTH-rP was demonstrated by normalization of serum PTH-rP after the tumorectomy and immunoreactivity for PTH-rP in the tumor cells.

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Section: Discussionmentioning

confidence: 99%

Uterine tumors resembling ovarian sex‐cord tumors producing parathyroid hormone‐related protein of the uterine cervix

Suzuki

Matsumoto

Fukunaga

et al. 2002

Pathology International

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“…Similar to teriparatide, abaloparatide equally induces osteosarcomas in Fischer 344 rats in dose‐ and time‐dependent fashions . Indeed, PTHrP induces humoral hypercalcemia of malignancy, and it is also closely involved in breast cancer initiation, growth, and metastasis . PTH induces tumorigenesis through upregulation of periostin, which plays a complex role in tumorigenesis .…”

Section: Mechanisms and Side Effects Of Osteoporosis Drugsmentioning

confidence: 99%

Novel insights into the complex architecture of osteoporosis molecular genetics

Saad

2019

Annals of the New York Academy of Sciences

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Osteoporosis is a prevalent osteodegenerative disease and silent killer linked to a decrease in bone mass and decline of bone microarchitecture, due to impaired bone matrix mineralization, raising the risk of fracture. Nevertheless, the process of bone matrix mineralization is still an unsolved mystery. Osteoporosis is a polygenic disorder associated with genetic and environmental risk factors; however, the majority of genes associated with osteoporosis remain largely unknown. Several signaling pathways regulate bone mass; therefore, dysregulation of a single signaling pathway leads to metabolic bone disease owing to high or low bone mass. Parathyroid hormone, core‐binding factor α‐1 (Cbfa1), Wnt/β‐catenin, the receptor activator of the nuclear factor kappa‐B (NF‐κB) ligand (RANKL), myostatin, and osteogenic exercise signaling pathways play pivotal roles in the regulation of bone mass. The myostatin signaling pathway increases bone resorption by activating the RANKL signaling pathway, whereas osteogenic exercise inhibits myostatin and sclerostin while inducing irisin that consequentially activates the Cbfa1 and Wnt/β‐catenin bone formation pathways. The aims of this review are to summarize what is known about osteoporosis‐related signaling pathways; define the role of these pathways in osteoporosis drug discovery; focus light on the link between bone, muscle, pancreas, and adipose integrative physiology and osteoporosis; and underline the emerging role of osteogenic exercise in the prevention of, and care for, osteoporosis, obesity, and diabetes.

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“…PTH-rP immunoreactivity was observed in small cell carcinomas of ovarian tumors [9]. In addition, cystadenocarcinoma is reported to be the major type of ovarian tumor associated with paraneoplastic hypercalcemia in humans [1,4,12,13]. Therefore, the ovarian adenocarcinoma in our case is suspected of affecting the pathogenesis of hypercalcemia associated with PTH-rP.…”

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confidence: 43%

“…68(9): 979-982, 2006 In dogs, the most common epithelial cell tumors of the ovary are papillary adenoma and adenocarcinoma [2,7,10]. In humans, paraneoplastic hypercalcemia is reported to be associated with ovarian tumors [1,4,12,13]. Parathyroid hormone-related protein (PTH-rP) is involved in the onset of paraneoplastic hypercalcemia [3,4,11].…”

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confidence: 54%

“…In humans, paraneoplastic hypercalcemia is reported to be associated with ovarian tumors [1,4,12,13]. Parathyroid hormone-related protein (PTH-rP) is involved in the onset of paraneoplastic hypercalcemia [3,4,11]. Paraneoplastic hypercalcemia has been detected in dogs diagnosed with lymphoma [8], but hypercalcemia is rarely associated with ovarian papillary adenocarcinoma.…”

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confidence: 99%

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Canine Ovarian Serous Papillary Adenocarcinoma with Neoplastic Hypercalcemia

et al. 2006

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ABSTRACT. A female golden retriever was referred to assess a history of a palpable abdominal mass. A serum chemistry analysis revealed elevated concentrations of blood urea nitrogen, creatinine, calcium, and parathyroid hormone-related protein (PTH-rP). Exploratory laparotomy revealed an ovoid mass within the right ovary. This mass was removed surgically by performing an ovariohysterectomy. The right ovarian mass was diagnosed as a serous papillary adenocarcinoma. Following surgery, the dog recovered, and the serum calcium and PTH-rP concentrations decreased. Therefore, concentrations of PTH-rP and calcium might be associated with serous papillary adenocarcinomas. Serial evaluation of the serum PTH-rP and calcium was useful for evaluating the prognosis. KEY WORDS: hypercalcemia, papillary adenocarcinoma, PTH-rP.J. Vet. Med. Sci. 68(9): 979-982, 2006 In dogs, the most common epithelial cell tumors of the ovary are papillary adenoma and adenocarcinoma [2,7,10]. In humans, paraneoplastic hypercalcemia is reported to be associated with ovarian tumors [1,4,12,13]. Parathyroid hormone-related protein (PTH-rP) is involved in the onset of paraneoplastic hypercalcemia [3,4,11]. Paraneoplastic hypercalcemia has been detected in dogs diagnosed with lymphoma [8], but hypercalcemia is rarely associated with ovarian papillary adenocarcinoma. In this paper, we describe a case of canine ovarian serous papillary adenocarcinoma with hypercalcemia.A 10-year-old female golden retriever that weighed 25.7 kg was referred for assessment of a history of weight loss over the preceding 7 days. The dog had been vomiting, anorexic, and polydipsic for 3 days. Physical examination revealed swelling of the vulva, a vulvar discharge, and a palpable abdominal mass. The serum concentrations of blood urea nitrogen (BUN; 62.5 mg/dl), creatinine (Cre; 2.13 mg/ dl), and calcium (25.7 mg/dl) were elevated. The serum concentration of estrogen was 45.3 pg/ml, and that of PTHrP (Mitsubishi-Kagaku Bio-Clinical Laboratories, Ibaraki, Japan) was 70.3 pmol/l (Table 1) [8]. Radiographs revealed ovoid masses in the thoracic cavity and abdomen (Fig.

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The development of hypercalcemia in a patient with an ovarian tumor producing parathyroid hormone-related protein

Cited by 25 publications

References 17 publications

Uterine tumors resembling ovarian sex‐cord tumors producing parathyroid hormone‐related protein of the uterine cervix

Uterine tumors resembling ovarian sex‐cord tumors producing parathyroid hormone‐related protein of the uterine cervix

Novel insights into the complex architecture of osteoporosis molecular genetics

Canine Ovarian Serous Papillary Adenocarcinoma with Neoplastic Hypercalcemia

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