The Guantan landslide, with a total displaced mass of about 468 9 10 4 m 3 , was triggered by the 2008 Wenchuan earthquake and succeeding rainfall in Jushui Town, Sichuan Province, China. The landslide occurred on an anti-dip hard rock slope with a weak rock founding stratum of 200 m in thickness. To investigate the failure mechanism of the Guantan landslide, dynamic behaviors of hard and soft rock slopes were investigated by means of large scale shaking table tests. The laboratory models attempted to simulate the field geological conditions of the Guantan landslide. Sinusoidal waves and actual seismic waves measured from the Wenchuan Earthquake were applied on the slope models under 37 loading configurations. The experimental results indicated that deformation mainly developed at a shallow depth in the upper part of the hard rock slope and in the upper (near the crest) and lower (near the toe) parts of the soft rock slope. An equation for predicting the depth of sliding plane was proposed based on the location of the maximum horizontal acceleration. Finally, it was concluded that the failure process of the Guantan landslide occurred in three stages: (1) toppling failure caused by compression of the underlying soft rock strata, (2) formation of crushed hard rock and sliding surface in soft rock as the result of seismic shocks, particularly in the horizontal direction, and (3) aftershock rainfall accelerates the process of mass movement along the sliding plane.