The Development of SPE Procedures and an UHPLC Method for the Simultaneous Determination of Ten Drugs in Water Samples

Abstract

Analytical procedures for the determination of pharmaceuticals from different therapeutic groups were proposed. These groups included the corticosteroids prednisolone and dexamethasone; the β-blockers sotalol, metoprolol, propranolol, and carvedilol; and the analgesic nonsteroidal antiinflammatory drugs paracetamol, aspirin, metamizole, and ketoprofen. Reversed-phase ultrahigh performance liquid chromatography with an ultraviolet detector, different columns, different mobile phases, and gradient elution programmes were used to obtain the best separations within the shortest possible time. Solid-phase extraction was examined as a preconcentration step. The Oasis HLB column, with the highest recoveries (over 90% for most of the drugs), was chosen for the analysis of surface waters. Limits of detection ranged from 0.06 to 0.39 μg L −1 for all drugs after optimisation of all analytical steps.

Determining Neu5Ac in infant formula with ultra‐performance liquid chromatography–tandem mass spectrometry

“…The results showed that the HLB column packing polymer had a good effect on purification, followed by operational simplicity and better reproducibility, and some published reports (Kamoda et al . ; Baranowska and Kowalski ) also confirm this result. Four millilitres of leachate (ultrapure water) and 3 mL of eluent (ammonia: methanol, 25:75, v/v) could improve the purification effect when the sample solution was added to the Oasis HLB column.…”

Enhanced voltammetric detection of paracetamol by using carbon nanotube modified electrode as an electrochemical sensor

“…The literature surveys revealed a number of already developed techniques for determining PC in different samples [15]. These techniques include titrimetric determination [16][17][18], liquid chromatography-mass spectroscopy [19][20], high performance-liquid chromatography [21][22], liquid chromatography [23], capillary electrophoresis [24], chemiluminescence [25], UV-Vis spectrometry [26][27], infrared spectroscopy [28], and flow [29][30] and batch [31] injection analyses. These methods offer high sensitivity, selectivity and accuracy, but difficulties of their use such as time-consuming measurement process, highly expert technicians required for the operation, and high cost instruments, limit their extensive applications.…”

Detection of 140 Clinically Relevant Antibiotic-Resistance Genes in the Plasmid Metagenome of Wastewater Treatment Plant Bacteria Showing Reduced Susceptibility to Selected Antibiotics

“…Polar, non-volatile or thermally degradable compounds and their derivatives cannot be analysed by GC, and LC is an essential tool for the analysis of these types of compounds (Chen et al 2008;Castiglioni et al 2005). Liquid chromatography with tandem-mass spectrometry (LC-MS/MS) is the most commonly used technique (Wu et al 2008;Baranowska and Kowalski 2010;Gros et al 2012).…”