The development of the innervation of the heart in the rat embryo

Gómez, Humberto Mateos

doi:10.1002/ar.1091300106

Cited by 43 publications

(19 citation statements)

References 16 publications

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“…In the right atria, TYR responsiveness suddenly changed from 0 to 100% between the 15th and 17th day of gestation, indicat ing the development of functional sympa thetic innervation to the sinus node during this period. This result is consistent with the morphological observaitons made by Gomez [1958] that sympathetic innervation of the rat heart begins from the sinus node on the 16th day of gestation.…”

Section: Effects Of Dbcamp Ibmx and Forskolinsupporting

confidence: 92%

Changes in Sensitivity of Rat Heart to Norepinephrine and Isoproterenol during Pre- and Postnatal Development and Its Relation to Sympathetic Innervation

Shigenobu

Tanaka²,

Kasuya³

1988

Dev Pharmacol Ther

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Possible correlation between sympathetic innervation and sensitivity to adrenergic agonists was examined with developing rat hearts. Chronotropic responses of right atria to tyramine (TYR) was absent until the 15th day of gestation. After the 17th day of gestation, the maximum chronotropism by TYR was equal to that by norepinephrine (NE), indicating the development of functional sympathetic innervation to sinus node during this period. In ventricle, TYR responsiveness was low at birth and increased with age, indicating an increased sympathetic innervation during early postnatal period. Both in atria and ventricle, sensitivity to NE was high in early fetal ages followed by a 10-fold decrease after the onset of sympathetic innervation. Similar changes were observed in the sensitivity to isoproterenol, suggesting the postjunctional nature of this sensitivity change. There was no difference in sensitivities to dibutyryl cyclic AMP and forskolin between ventricles from 1-day- and 1- week-old neonates, suggesting changes in beta-receptor-adenylate cyclase system as a cause of this sensitivity change. The observed parallelism between functional sympathetic innervation and postjunctional sensitivity changes supports the hypothesis that sympathetic nerve exerts trophic influence upon cardiac muscle development to regulate the sensitivity to agonists.

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Section: Effects Of Dbcamp Ibmx and Forskolinsupporting

confidence: 92%

Changes in Sensitivity of Rat Heart to Norepinephrine and Isoproterenol during Pre- and Postnatal Development and Its Relation to Sympathetic Innervation

Shigenobu

Tanaka²,

Kasuya³

1988

Dev Pharmacol Ther

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“…Although it has been suggested that these changes were caused by prejunctional mechanisms (Mackenzie & Standen, 1980), we have observed in the right atria and in the ventricle that sensitivity to Iso decreased in parallel to the sensitivity to NA during development Tanaka et al, 1988a,b), and concluded that the changes were mainly postjunctional in nature. This decrease in sensitivity correlates well with the increase in sympathetic innervation in each region, as determined by examining responsiveness to tyramine Tanaka et al, 1988a,b), NA content (Iversen et al, 1967;Mirkin, 1972), intensity of the fluorescence of catecholamine containing fibres (De Champlain et al, 1970;Lipp & Rudolph, 1972), capacity for NA uptake and retention (Iversen et al, 1967) and by morphological observations (Gomez, 1958).…”

Section: Discussionmentioning

confidence: 74%

Role of β‐adrenoceptor‐adenylate cyclase system in the developmental decrease in sensitivity to isoprenaline in foetal and neonatal rat heart

Tanaka¹,

Shigenobu²

1990

British J Pharmacology

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1 The inotropic and chronotropic sensitivity to noradrenaline and isoprenaline (Iso) of foetal and ngonatal rat heart decreases as the heart becomes sympathetically innervated. In the present study, we have examined adenylate cyclase (AC) activation and fl-adrenoceptor binding to determine whether a developmental decrease in sensitivity was demonstrable in the fl-receptor-AC system of atrial and ventricular membranes from the 15 day foetus and 1 day and 7 day neonates. 2 While the maximum activation of AC by Iso increased with age, the sensitivity expressed in terms of pD2 values decreased from the 15th foetal day to the first day after birth in the atria, and from the first day to the 7th day after birth in the ventricle. 3 In contrast, activation of AC by forskolin was almost identical at all ages both in atria and ventricle. 4 The maximum equilibrium binding of [3H]-dihydroalprenolol decreased with age, the dissociation constant being about the same at all ages in both the atria and ventricle. 5 In conclusion, we have demonstrated a developmental decrease in the sensitivity of AC to Iso in myocardial membrane fractions consistent with the developmental decrease in chronotropic and inotropic sensitivity to fl-adrenoceptor agonists. Although a reduction in ,B-adrenoceptor number partly accounts for the decrease in sensitivity, some other factors such as decreased coupling to AC may largely be responsible.

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“…Experimental and developmental studies of the autonomic cardiac nervous system have also been conducted in animals such as the mouse, rat, rabbit, chick, and dog (Armour et al, 1972;Benítez et al, 1959;Brack et al, 2011;Gomez, 1958;Haws and Burgess, 1978;Hildreth et al, 2008Hildreth et al, , 2009Kirby et al, 1980;Kuratani et al, 1991;Kuratani and Tanaka, 1990;Levy et al, 1966;Mabe and Hoover, 2011;Meyer et al, 2010;Mizeres, 1955Mizeres, , 1957Mizeres, , 1958Mizuno et al, 2010;Oliveira et al, 2010;Roberts, 1991;Schwartz, 2010;Scherlag et al, 2011;Shaner, 1930;Shoba and Tay, 2000;Uchida et al, 2010;Verberne et al, 1998). However, huge differences in the cardiac nervous system between humans and the experimental animals have been recognized (Batulevicius et al, 2003;Brugnaro et al, 2003;Kawashima, 2011;McKibben and Getty, 1968;Rysevaite et al, 2011;Pauza et al, 2002a,b).…”

Section: Introductionmentioning

confidence: 99%

Systematic and comparative morphologies of the extrinsic cardiac nervous system in lemurs (Primates: Strepsirrhini: Infraorder Lemuriformes, Gray, 1821) with evolutionary morphological implications

Kawashima

Thorington

Sato

2013

Zoologischer Anzeiger - A Journal of Comparative Zoology

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The development of the innervation of the heart in the rat embryo

Cited by 43 publications

References 16 publications

Changes in Sensitivity of Rat Heart to Norepinephrine and Isoproterenol during Pre- and Postnatal Development and Its Relation to Sympathetic Innervation

Changes in Sensitivity of Rat Heart to Norepinephrine and Isoproterenol during Pre- and Postnatal Development and Its Relation to Sympathetic Innervation

Role of β‐adrenoceptor‐adenylate cyclase system in the developmental decrease in sensitivity to isoprenaline in foetal and neonatal rat heart

Systematic and comparative morphologies of the extrinsic cardiac nervous system in lemurs (Primates: Strepsirrhini: Infraorder Lemuriformes, Gray, 1821) with evolutionary morphological implications

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