The DHPR Calcium Current in Mammalian Skeletal Muscle: Physiological Necessity or Tolerated Evolutionary Remnant?

Dayal, Anamika; Schrötter, Kai; Melzer, Werner; Schwarzer, Christoph; Grabner, Manfred

doi:10.1016/j.bpj.2013.11.748

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2017

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“…Mouse models have been generated with mutations in the Ca V 1.1 channel pore that abolish the calcium conductance (Dayal et al . ; Lee et al . ).…”

Section: Introductionmentioning

confidence: 99%

How and why are calcium currents curtailed in the skeletal muscle voltage‐gated calcium channels?

Flucher

Tuluc

2017

The Journal of Physiology

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Voltage‐gated calcium channels represent the sole mechanism converting electrical signals of excitable cells into cellular functions such as contraction, secretion and gene regulation. Specific voltage‐sensing domains detect changes in membrane potential and control channel gating. Calcium ions entering through the channel function as second messengers regulating cell functions, with the exception of skeletal muscle, where CaV1.1 essentially does not function as a channel but activates calcium release from intracellular stores. It has long been known that calcium currents are dispensable for skeletal muscle contraction. However, the questions as to how and why the channel function of CaV1.1 is curtailed remained obscure until the recent discovery of a developmental CaV1.1 splice variant with normal channel functions. This discovery provided new means to study the molecular mechanisms regulating the channel gating and led to the understanding that in skeletal muscle, calcium currents need to be restricted to allow proper regulation of fibre type specification and to prevent mitochondrial damage.

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“…Mouse models have been generated with mutations in the Ca V 1.1 channel pore that abolish the calcium conductance (Dayal et al . ; Lee et al . ).…”

Section: Introductionmentioning

confidence: 99%

How and why are calcium currents curtailed in the skeletal muscle voltage‐gated calcium channels?

Flucher

Tuluc

2017

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

The DHPR Calcium Current in Mammalian Skeletal Muscle: Physiological Necessity or Tolerated Evolutionary Remnant?

Cited by 1 publication

References 0 publications

How and why are calcium currents curtailed in the skeletal muscle voltage‐gated calcium channels?

How and why are calcium currents curtailed in the skeletal muscle voltage‐gated calcium channels?

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