The diagnostic and prognostic value of exosome-derived long non-coding RNAs in cancer patients: a meta-analysis

Mu, Huiwen; Zhang, Sujie; Yao, Zhaoying; Liu, Yunxin; Kang, Lin; Zhao, Zheng; Zhu, Yubing

doi:10.1007/s10238-020-00638-z

Cited by 12 publications

(8 citation statements)

References 45 publications

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“…Other non‐coding RNAs, like lncRNAs and microRNAs, were reported to be present in exosomes earlier and might be served as new biomarkers in cancer diagnosis. The sensitivity, specificity, and AUC of exosomal lncRNAs for the diagnosis of cancer were 0.83, 0.80, and 0.88, respectively 12 . A meta‐analysis including 1591 patients revealed that the pooled sensitivity, specificity, and AUC of exosomal microRNAs were 0.86, 0.89, and 0.94, respectively 38 .…”

Section: Discussionmentioning

confidence: 99%

The diagnostic value of exosomal circular RNAs in cancer patients: A systematic review and meta‐analysis

et al. 2022

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Background: Recently, serum exosomal circular RNAs (circRNAs) were applied to discriminate cancer patients from healthy individuals, indicating that exosomal circRNAs have the potential to be novel biomarkers for cancer diagnosis. This study aims to summarize the role of exosomal circRNAs in cancer diagnosis by a meta-analysis.Methods: A comprehensive literature search was conducted up to July 2021 in PubMed, Web of Science, EMBASE, and Cochrane Database. To evaluate the diagnostic value, the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were pooled. Threshold effect followed by subgroup analysis and meta-regression were performed to explore the source of heterogeneity. Sensitivity analysis was performed to assess the stability of this meta-analysis model. Fagan plots and likelihood ratio scattergrams were used to explore the potential clinical significance.Results: Ten eligible studies with 514 controls and 557 patients were included in this diagnostic meta-analysis. The pooled sensitivity, specificity, PLR, NLR, and DOR were 0.75 (95% CI: 0.65-0.83), 0.84 (95% CI, 0.78-0.89), 5.87 (95% CI, 0.28 (95% CI, and 21.15 (95% CI,, respectively. The AUC was 0.89 (95% CI, 0.86-0.91). Sensitivity analysis showed that four studies had an impact on the pooled results and mainly contributed to the heterogeneity.Fagan's nomogram revealed that the prior probability of 20%, the post probability positive, the post probability negative were 59% and 6%, respectively. Conclusion:Our results suggested that exosomal circRNAs might serve as powerful biomarkers in detecting cancers with high sensitivity and specificity. However, more well-designed and multicenter diagnostic tests are needed to validate our results.

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Section: Discussionmentioning

confidence: 99%

The diagnostic value of exosomal circular RNAs in cancer patients: A systematic review and meta‐analysis

et al. 2022

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“…LncRNAs play an important role in the oncogenesis, especially in the development and progression of tumors through the wingless‐type (Wnt), Hedgehog, Notch, and phosphoinositide 3-kinases (PI3Ks)/protein kinase B alpha (AKT)/mammalian target of rapamycin (mTOR) signaling pathways [ 41 ]. Dysregulation of several lncRNAs has been found in various cancer types such as breast, ovarian, cervical, and prostate cancers, suggesting the use of lncRNAs as markers for cancer detection and prognosis, as well as for therapeutic purposes [ 41 , 42 ].…”

Section: Lncrnas and Bmps Signaling Pathwaymentioning

confidence: 99%

Functions of the bone morphogenetic protein signaling pathway through non-coding RNAs

Мухаметов

Lyulin²,

Borzunov³

et al. 2022

Non-coding RNA Research

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“…A meta-analysis by Zhu et al showed that liquid biopsy is the best for the diagnosis of pancreatic cancer, while sEVs higher specificity and sensitivity compared with liquid biopsy methods such as ctDNA and CTC [ 101 ]. In addition, miRNAs [ 102 ] and lncRNAs [ 103 ] carried by sEVs are the most promising biomarkers in the diagnosis of pancreatic cancer. Currently, although the use of sEVs remains largely theoretical, ongoing clinical trials will reveal the potential of sEVs in pancreatic cancer development and therapy.…”

Section: Future Prospects Of Sevs In Pancreatic Cancermentioning

confidence: 99%

Small extracellular vesicles: from mediating cancer cell metastasis to therapeutic value in pancreatic cancer

et al. 2022

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Pancreatic cancer is a highly malignant tumor and, is extremely difficult to diagnose and treat. Metastasis is one of the critical steps in the development of cancer and uses cell to cell communication to mediate changes in the microenvironment. Small extracellular vesicles (sEVs)-carry proteins, nucleic acids and other bioactive substances, and are important medium for communication between cells. There are two primary steps in sVEs-mediated metastasis: communication between pancreatic cancer cells and their surrounding microenvironment; and the communication between primary tumor cells and distant organ cells in distant organs that promotes angiogenesis, reshaping extracellular matrix, forming immunosuppressive environment and other ways to form appropriate pre-metastasis niche. Here, we explore the mechanism of localization and metastasis of pancreatic cancer and use sEVs as early biomarkers for the detection and treatment of pancreatic cancer. Graphical Abstract

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The diagnostic and prognostic value of exosome-derived long non-coding RNAs in cancer patients: a meta-analysis

Cited by 12 publications

References 45 publications

The diagnostic value of exosomal circular RNAs in cancer patients: A systematic review and meta‐analysis

The diagnostic value of exosomal circular RNAs in cancer patients: A systematic review and meta‐analysis

Functions of the bone morphogenetic protein signaling pathway through non-coding RNAs

Small extracellular vesicles: from mediating cancer cell metastasis to therapeutic value in pancreatic cancer

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