The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis

Shirvani, Mohammad; Soufi, Farhad; Nouralishahi, Alireza; Vakili, Kimia; Salimi, Amirhossein; Lucke‐Wold, Brandon; Mousavi, Farideh; Mohammadzadehsaliani, Saman; Khanzadeh, Shokoufeh

doi:10.1155/2022/5744008

Cited by 10 publications

(3 citation statements)

References 71 publications

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“…However, all systemic changes found in patients with AMD are subtle and thus clearly distinguishable from the clear immunological activity observed in patients with GCA. Similar subtle immunological findings are observed for other prevalent causes of vision loss in the elderly [ 27 , 28 , 29 , 30 ]. These aspects demonstrate the challenges in diagnosing GCA in the elderly, as they can have various other co-morbidities.…”

Section: Discussionsupporting

confidence: 81%

Is Erythrocyte Sedimentation Rate Necessary for the Initial Diagnosis of Giant Cell Arteritis?

Hansen

Klefter

Terslev

et al. 2023

Life

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Giant cell arteritis (GCA) is an ophthalmological emergency that can be difficult to diagnose and prompt treatment is vital. We investigated the sequential diagnostic value for patients with suspected GCA using three biochemical measures as they arrive to the clinician: first, platelet count, then C-reactive protein (CRP), and lastly, erythrocyte sedimentation rate (ESR). This retrospective cross-sectional study of consecutive patients with suspected GCA investigated platelet count, CRP, and ESR using diagnostic test accuracy statistics and odds ratios (ORs) in a sequential fashion. The diagnosis was established by experts at follow-up, considering clinical findings and tests including temporal artery biopsy. A total of 94 patients were included, of which 37 (40%) were diagnosed with GCA. Compared with those without GCA, patients with GCA had a higher platelet count (p < 0.001), CRP (p < 0.001), and ESR (p < 0.001). Platelet count demonstrated a low sensitivity (38%) and high specificity (88%); CRP, a high sensitivity (86%) and low specificity (56%); routine ESR, a high sensitivity (89%) and low specificity (47%); and age-adjusted ESR, a moderate sensitivity (65%) and moderate specificity (65%). Sequential analysis revealed that ESR did not provide additional value in evaluating risk of GCA. Initial biochemical evaluation can be based on platelet count and CRP, without waiting for ESR, which allows faster initial decision-making in GCA.

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Section: Discussionsupporting

confidence: 81%

Is Erythrocyte Sedimentation Rate Necessary for the Initial Diagnosis of Giant Cell Arteritis?

Hansen

Klefter

Terslev

et al. 2023

Life

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“…NLR and platelet-to-lymphocyte ratio have been defined as inflammation biomarkers. Although they have usually been investigated as predictors of prognosis of some diseases, such as cancer ( Diem et al, 2017 ; Graziano et al, 2019 ; Mungan et al, 2020 ) and acute ischemic stroke ( Chen et al, 2020 ; Gong et al, 2021 ), papers for glaucoma are limited ( Ozgonul et al, 2016b ; Li et al, 2021 ; Shirvani et al, 2022 ). A retrospective study investigated the predictive value of NLR and platelet-to-lymphocyte ratio levels in the progression and prognosis of patients with POAG and ocular hypertension ( Ozgonul et al, 2016a ).…”

Section: Discussionmentioning

confidence: 99%

Blood cell traits and risk of glaucoma: A two-sample mendelian randomization study

Song

Fan

2023

Front. Genet.

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Importance: Glaucoma is the second leading cause of blindness in the world. The causal direction and magnitude of the association between blood cell traits and glaucoma is uncertain because of the susceptibility of observational studies to confounding and reverse causation.Objective: To explore whether there is a causal relationship of blood cell traits including white blood cell (WBC) count (WBCC) and its subtypes [basophil cell count (BASO), monocyte cell count (MONO), lymphocyte cell count (LYMPH), eosinophil cell count (EOS), neutrophil cell count (NEUT)], red blood cell (RBC) count (RBCC), red blood distribution width (RDW), platelet count (PLT), and plateletcrit (PCT) on glaucoma risk.Methods: A two-sample Mendelian randomization (MR) analysis was conducted. Genome-wide significant single nucleotide polymorphisms (SNPs) from published genome-wide association studies (GWAS) on human blood cell traits were utilized as exposure instruments and the dataset for outcome was from the GWAS summary data of glaucoma. In the univariable MR analysis, we examined the association between genetic evidence of blood cell traits and glaucoma. To further investigate the potential causal mechanisms underlying the observed association, we performed multivariable MR analysis with three models, taking into account the mediator effect of inflammation and oxidative stress. According to Bonferroni-corrected for the 10 exposures in 3 methods, the MR study yielded a statistically significant p-value of 0.0017.Results: Genetically BASO, PCT, LYMPH, and PLT were potentially positively associated with glaucoma in the European ancestry [BASO: Odds ratio (OR) = 1.00122, 95% confidence interval (CI), 1.00003–1.00242, p = 0.045; PCT: OR = 1.00078, 95% CI, 1.00012–1.00143, p = 0.019; LYMPH: OR = 1.00076, 95% CI, 1.00002–1.00151, p = 0.045; PLT: OR = 1.00065, 95% CI, 1.00006–1.00123, p = 0.030], There was insufficient evidence to support a causal association of MONO, NEUT, EOS, WBCC, RBCC and RDW (MONO: OR = 1.00050, p = 0.098; NEUT: OR = 1.00028, p = 0.524; EOS: OR = 1.00020, p = 0.562; WBCC: OR = 1.00008, p = 0.830; RBCC: OR = 0.99996, p = 0.920; RDW: OR = 0.99987, p = 0.734) with glaucoma. The multivariable MR with model 1, 2, and 3 demonstrated that BASO, PCT, LYMPH, and PLT were still potentially genetically associated with the risk of glaucoma.Conclusion: Our study reveals a genetic predisposition to higher LYMPH, BASO, PLT, and PCT are associated with a higher risk of glaucoma, whereas WBCC, MONO, EOS, NEUT, RBCC, and RDW are not associated with the occurrence of glaucoma. This finding also supports previous observational studies associating immune components with glaucoma, thus provide guidance on the predication and prevention for glaucoma.

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“…Sistemik inflamatuar yanıt, birçok sistemik ve oküler hastalığının seyrinde rol oynamaktadır. Sistemik immün inflamasyon indeksi (SII), nötrofil/lenfosit oranı (NLR) ve platelet / lenfosit oranı (PLR) gibi hematolojik biyobelirteçler sistemik inflamasyonun göstergeleri olarak kabul edilmektedir (5). Bu parametreler, kuru göz hastalığı, idiyopatik epiretinal membran, keratokonus ve glokom gibi oküler hastalıklarda tanısal ve prognostik rolleri açısından araştırılmıştır (6)(7)(8).…”

Section: Introductionunclassified

Comparison of Systemic Inflammation Markers in Patients with Different Types of Lacrimal Drainage System Obstruction

TOPÇU,

KEMER ATİK,

ULAŞ

et al. 2023

Batı Karadeniz Tıp Dergisi

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Amaç: Üst ve alt lakrimal drenaj sistemi (LDS) tıkanıklığı olan olgularda preoperatif kan testlerinden sistemik inflamasyon belirteçlerini araştırmak ve gruplar arasında bu inflamatuar belirteçleri ve uygulanan cerrahi tedavilerin başarısını karşılaştırmak amaçlandı. Gereç ve Yöntemler: Bu retrospektif çalışmada 2021-2023 yılları arasında LDS tıkanıklığı olan olguların dosyaları incelendi. Üst LDS tıkanıklığı olan olgular Grup 1'e ve alt LDS tıkanıklığı olan olgular Grup 2'ye dahil edildi. Tüm hastaların ameliyat öncesi tam kan sayımından, sistemik inflamatuar belirteçler olan nötrofil-lenfosit oranı (NLR), platelet-lenfosit oranı (PLR) ve ortalama platelet hacmi (MPV) elde edildi. Nötrofil (N), lenfosit (L) ve platelet (P) sayılarına (NxP/L) dayanan sistemik immün inflamasyon indeksi (SII) bir biyobelirteç olarak hesaplandı. Her iki grubun sistemik inflamasyon belirteçleri ve cerrahi tedavi başarısı karşılaştırıldı. Bulgular: Çalışmaya 46 (Grup 1=26, Grup 2=20) olgunun 57 (Grup 1= 37, Grup 2=20) gözü dahil edildi. Grup 1'deki olguların yaş ortalaması 52,3±9,4 yıl iken; Grup 2'de 47,1±9,0 yıl idi (p=0,067). Cinsiyet dağılımı Grup 1’de 18 kadın, 8 erkek; Grup 2’de 15 kadın 5 erkek idi (p=0,749). Grup 1'de ortalama nötrofil sayısı 4,98±2,36 10^3/uL, NLR 2,25±1,19 ve PLR 114,7±29,2 idi. Bu değerler Grup 2'de sırasıyla 3,91±0,85 10^3/uL, 1,57±0,48 ve 95,5±27,9 idi (p

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The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis

Cited by 10 publications

References 71 publications

Is Erythrocyte Sedimentation Rate Necessary for the Initial Diagnosis of Giant Cell Arteritis?

Is Erythrocyte Sedimentation Rate Necessary for the Initial Diagnosis of Giant Cell Arteritis?

Blood cell traits and risk of glaucoma: A two-sample mendelian randomization study

Comparison of Systemic Inflammation Markers in Patients with Different Types of Lacrimal Drainage System Obstruction

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