The diagnostic value of white blood cell, neutrophil, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio in patients with primary angle closure glaucoma

Li, Shengjie; Cao, Wenjun; Han, Jianping; Tang, Binghua; Sun, Xinghuai

doi:10.18632/oncotarget.16571

Cited by 36 publications

(40 citation statements)

References 40 publications

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“…For example, Duvesh et al [30] reported significantly higher IL-8, eotaxin, IP-10 (p < 0.001) and macrophage inflammatory protein-1-beta levels in the aqueous humour of chronic PACG patients when compared to the controls. Li et al [3] suggested that the mean neutrophil, neutrophil to lymphocyte ratio and WBC values were higher in the PACG patients than in the healthy controls and that they were the lowest in the mild PACG group, followed by the moderate and severe groups. It is worth noting that a state of inflammation has been regarded as an important RDW determinant [31].…”

Section: Discussionmentioning

confidence: 99%

“…Although the underlying mechanisms leading to glaucomatous atrophy in PACG cases are not fully understood, several mechanisms have been suggested. For example, inflammation [3], microangiopathy [4][5][6][7][8][9] and oxidative stress [10,11] are all currently being discussed in terms of the leading factors causing PACG, which can damage the optic nerve and lead to the progressive loss of retinal ganglion cells and their axons.…”

Section: Introductionmentioning

confidence: 99%

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Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction

et al. 2019

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The red blood cell distribution width (RDW) is a simple and inexpensive laboratory parameter that can be linked to oxidative stress, inflammation and microvascular flow resistance. For this research, we performed a large-sample case-control study to describe the relationships between the RDW and primary angle-closure glaucoma (PACG). A total of 1191 PACG patients (422 males and 769 females), who were divided into mild, moderate and severe PACG groups, and 982 healthy controls (344 males and 638 females) were recruited between January 2008 and June 2018. Detailed eye and physical examinations were performed for each subject. Based on the laboratory results, the mean RDW was significantly higher (p < 0.001) in the PACG group (13.01 ± 0.82%) than in the control group (12.65 ± 0.53%). Moreover, the mean RDW level was lower (p < 0.05) in the mild PACG group than in the moderate and severe PACG groups. The Pearson correlation analyses showed significant positive correlations between the mean deviation and the RDW (r = 0.141, p < 0.001) and the intraocular pressure and the RDW (r = 0.085, p = 0.004). After adjusting for the confounding factors, the logistic regression analyses indicated that the odds ratio for the PACG group was 2.318 (p < 0.001, 95% confidence interval 1.997, 2.690) when compared to the control group. Additionally, an increased RDW was associated with the PACG severity, and this trend was also observed in the gender and age subgroups. In summary, the results of our study showed that an elevated RDW was associated with PACG and its severity. If future studies confirm this relationship, the use of an RDW assessment may help to predict the PACG severity in each patient in order to better customise effective prevention treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction

et al. 2019

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“…The NLR is also a new indicator for several inflammation-related ocular diseases. The NLR can be used as a novel biomarker in primary open-angle glaucoma, and WBC counts have diagnostic value in patients with primary angle-closure glaucoma (18,19). Kurtul et al (20) reported that NLR is a simple, inexpensive, and reliable prognostic biomarker for age-related macular degeneration.…”

Section: Discussionmentioning

confidence: 99%

The Optimal Cutoff Value of Neutrophil/Lymphocyte Ratio in Severe Grades of Diabetic Retinopathy Short Title: NLR in Diabetic Retinopathy

İlhan¹

2019

Beyoglu Eye J

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The aim of this study was to define the optimal cutoff value of the neutrophil/lymphocyte ratio (NLR) to predict severe grades of diabetic retinopathy (DR). Methods: A total of 40 patients with proliferative DR (PDR) and 40 patients with severe non-proliferative DR (NPDR) were included this prospective, case control study, and 35 age-and sex-matched healthy subjects were recruited as a control group. White blood cell (WBC) count mean values and ratios were compared between the groups. Results: The groups were statistically similar in terms of age and sex. The neutrophil, lymphocyte, monocyte, platelet counts, and main platelet volume (MPV) values were similar in all 3 groups (all p values >0.05). The mean NLR was 2.67±1.02 in the PDR cases, 2.16±0.58 in severe NPDR, and 1.85±0.49 in the control group, which represented a statistically significant difference between the 3 groups (p=0.003). In post-hoc analysis, the NLR of the PDR and severe NPDR groups was statistically significantly greater than that of the control group (p=0.002 and p=0.048, respectively), but there was no statistically significant difference between the PDR and severe NPDR groups (p=0.083). The monocyte/lymphocyte, platelet/lymphocyte, and MPV/lymphocyte ratios were also similar in all 3 groups (all p values >0.05). Conclusion: An NLR value of 2.11 or more predicted DR (PDR or severe NPDR) with a sensitivity of 76% and a specificity of 80%.

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“…Clinical laboratory markers of systemic inflammatory status derived from complete blood count (CBC), including the neutrophil-to-lymphocyte ratio (NLR), plateletto-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and the systemic immune inflammation index (SII), have been proposed as prognostic indicators in several diseases, including myocardial infarction, diabetes mellitus, pancreatitis, and cancer [11][12][13][14][15][16]. Evaluation of those markers in primary angle closure glaucoma, retinal vein occlusion, age-related macular degeneration, diabetic retinopathy, keratoconus, pseudoexfoliation syndrome, and pseudoexfoliation glaucoma has also suggested their potential roles as biomarkers and predictors of prognosis in ocular diseases [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Associations between Blood Cell Profiles and Primary Open-Angle Glaucoma: A Retrospective Case-Control Study

Tang

Han

et al. 2020

Ophthalmic Res

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Purpose: We aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune inflammation index (SII) were associated with primary open-angle glaucoma (POAG). Materials and Methods: This retrospective case-control study included 240 patients with POAG and 300 age- and sex-matched control subjects. Complete ophthalmological examination and blood count measurements were performed for all subjects. Results: The values of NLR, PLR, and SII in the POAG group were significantly increased compared with the control group (p < 0.001; p = 0.012; p < 0.001). However, the LMR value was lower in the POAG patients than in the control group (p < 0.001). When we divided the subjects into different age and gender subgroups, the NLR and SII values in the POAG patients were always higher than those in the control group. In the comparison of laboratory parameters in POAG subjects stratified according to severity, we also found that NLR and SII increased with the severity. The receiver operating characteristic (ROC) analysis revealed that the areas under the ROC curve of NLR, PLR, LMR, and SII to predict patients with POAG were found to be 0.627, 0.569, 0.382, and 0.986, respectively. The best cutoff point of NLR was 1.998 with a sensitivity of 59.8% and a specificity of 63.0%, and the SII was 947.365 with a sensitivity of 95.4% and a specificity of 95.7%. Multivariable logistic regression analysis showed that NLR was positively associated with mean deviation; moreover, NLR and SII were independent indicators correlated with POAG (OR 1.502; 95% CI 1.227–1.839; p < 0.001; OR 1.02; 95% CI 1.009–1.021; p < 0.001). Conclusion: We speculated that elevated NLR and SII might serve as readily available inflammatory predictors in POAG patients.

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The diagnostic value of white blood cell, neutrophil, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio in patients with primary angle closure glaucoma

Cited by 36 publications

References 40 publications

Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction

Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction

The Optimal Cutoff Value of Neutrophil/Lymphocyte Ratio in Severe Grades of Diabetic Retinopathy Short Title: NLR in Diabetic Retinopathy

Associations between Blood Cell Profiles and Primary Open-Angle Glaucoma: A Retrospective Case-Control Study

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