The difference in serum alkaline phosphatase levels between girls with precocious puberty and those with normal puberty

Abstract

PurposeSerum alkaline phosphatase (ALP) level is the most valid marker of bone formation. Precocious puberty (PP) in girls is characterized by early growth acceleration. The aim of this study was to determine whether serum ALP levels differ between girls with PP and those with normal puberty, and whether ALP level varies with age or Tanner stage.MethodsThis retrospective study included girls with PP (n=61) and normal puberty (n=71) who visited the outpatient clinic at Department of Pediatrics, Chungnam National University Hospital from March 2010 to August 2011. We obtained age, height, parental height, weight, bone age, Tanner stage, and concentrations of luteinizing hormone, follicular-stimulating hormone, estradiol, ALP, and insulin-like growth factor-1 (IGF-1) from the participants' medical records.ResultsAge and predicted adult height were significantly lower in girls with PP than in those with normal puberty. The height standard deviation score (SDS), weight SDS, body mass index, midparental height, bone age, and IGF-1 level were higher in girls with PP than in those with normal puberty. ALP level was significantly higher in 5- to 8-year-old girls with PP than in age-matched girls with normal puberty. The mean ALP levels were higher in girls with PP than bone age-matched girls with normal puberty (P=0.0003)ConclusionSerum ALP level showed the significance differences between girls with PP and those with normal puberty. The reasons for and the mechanisms underlying this elevation in serum ALP level in girls with PP should be investigated further.

Preventive Effect of Anemarrhenae rhizome and Phellodendri cortex on Danazol-Induced in Precocious Puberty in Female Rats and Network Pharmacological Analysis of Active Compounds

“…The results revealed that, compared with the other groups, treatment with APE in the long term slightly reduced the body length of rats ( Figure 3 b). We also measured the serum ALP level, a marker of bone maturation [ 19 ], to evaluate the effect of APE on regulating the growth rate. Only leuplin showed an inhibitory effect to restore the serum ALP concentration to the basal level; however, APE treatment did not change the serum ALP level in the PP model ( Figure 3 c).…”

Anticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification

“…As plasma ALP levels are closely related to osteoblastic activity and bone growth, ALP activity is generally higher in younger individuals 27 . Findings in the current study align with this phenomena, as predose KK/HlJ mice (6 weeks of age at necropsy) had numerically higher plasma ALP activity compared with that of the postdose, vehicle-treated C57BL/6J mice and postdose, vehicle-treated control KK/HlJ mice (both 20 weeks of age at necropsy; Fig.…”

The Relationship between Chronological Age, Dental Age, and Salivary Alkaline Phosphatase in Indonesian Children Aged 8-14 Years: A Cross-Sectional Study

“…From some salivary components, there are few components that sounds interesting to be observed in accordance to dental aging and maturation. One of them is alkaline phosphatase, in which the application for bone growth isn’t no longer debatable 30 .…”