The differential distribution and relationship of serotoninergic and peptidergic fibers to sympathoadrenal neurons in the intermediolateral cell column of the rat: A combined retrograde axonal transport and immunofluorescence study

Holets, Vicky R.; Elde, Robert

doi:10.1016/0306-4522(82)91123-x

Cited by 201 publications

(50 citation statements)

References 70 publications

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“…The DA innervation exactly mimics this discontinuous organization, indicating that the DA fibers are aimed at the sympathetic preganglionic neurons and their dendrites. A similar "ladderlike" pattern of innervation was found with many other transmitters, including NA, serotonin, adrenaline, and various peptides like substance P, oxytocin, vasopressin, neurotensin, somatostatin, neuropeptide Y, and enkephalin (Swanson and McKellar, 1979;Glazer and Ross, 1980;Holets and Elde, 1982;Westlund et al, 1983;Romagnano and Hamill, 1984;Krukoff, 1987;Fuxe et al, 1990;Hosoya et al, 1991;Rajaofetra et al, 1992b).…”

Section: Methodological Aspectsmentioning

confidence: 89%

Distribution of dopamine immunoreactivity in the rat, cat, and monkey spinal cord

et al. 1996

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In the present study, the distribution of dopamine (DA) was identified light microscopically in all segments of the rat, cat, and monkey spinal cord by using immunocytochemistry with antibodies directed against dopamine. Only fibers and (presumed) terminals were found to be immunoreactive for DA. Strongest DA labeling was present in the sympathetic intermediolateral cell column (IML). Strong DA labeling, consisting of many varicose fibers, was found in all laminae of the dorsal horn, including the central canal area (region X), but with the exception of the substantia gelatinosa, which was only sparsely labeled, especially in rat and monkey. In the motoneuronal cell groups DA labeling was also strong and showed a fine granular appearance. The sexually dimorphic cremaster nucleus and Onuf's nucleus (or its homologue) showed a much stronger labeling than the surrounding somatic motoneurons. In the parasympathetic area at sacral levels, labeling was moderate. The remaining areas, like the intermediate zone (laminae VI-VIII), were only sparsely innervated. The dorsal nucleus (column of Clarke) showed the fewest DA fibers, as did the central cervical nucleus, suggesting that cerebellar projecting cells were avoided by the DA projection. In all species, the descending fibers were located mostly in the dorsolateral funiculus, but laminae I and III also contained many rostrocaudally oriented fibers. It is concluded that DA is widely distributed within the spinal cord, with few differences between species, emphasizing that DA plays an important role as one of the monoamines that influences sensory input as well as autonomic and motor output at the spinal level.

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Section: Methodological Aspectsmentioning

confidence: 89%

Distribution of dopamine immunoreactivity in the rat, cat, and monkey spinal cord

et al. 1996

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“…Furthermore, there appears to be a differential distribution of oxytocin immunoreactive varicosities along the spinal cord. For example, oxytocin fibres appear to avoid adrenal-medullary projecting SPNs when comparisons of fibre density are made with superior cervical projecting SPNs (Holets and Elde, 1982;Appel and Elde, 1988) and this may reflect organ specific regulation (Krukoff et al, 1985). However, oxytocin fibres have been reported to congregate around T9 (Swanson and McKellar, 1979).…”

Section: Oxytocinmentioning

confidence: 89%

Neurochemistry of the paraventricular nucleus of the hypothalamus: Implications for cardiovascular regulation

Pyner

2009

Journal of Chemical Neuroanatomy

148

156

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“…morphine has little effect on blood pressure (Yasuoka and Yaksh 1983;Cousins and Mather 1984;Loomis et al 1988;Solomon and Gebhart 1988;Gaumann et al 1990;Nagasaka and Yaksh 1995). The typical failure of opiates to alter autonomic outflow is puzzling, given the presence of enkephalinergic innervation (Holets and Elde 1982) and the significant inhibition of preganglionic neurons in the spinal cord by morphine (Guyenet and Stornetta 1982). The failure of opiates to alter sympathetic outflow may reflect concurrent depression of preganglionic neurons as well as of a tonic inhibition, perhaps exerted by local glycinergic interneurons on intermediolateral cells (Chiba and Semba 1991).…”

Section: Discussionmentioning

confidence: 96%

Blood pressure changes after intrathecal co-administration of calcium channel blockers with morphine or clonidine at the spinal level

Horváth

Brodacz

Holzer‐Petsche

2002

Naunyn-Schmiedeberg's Archives of Pharmacology

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Opioids, alpha(2)-adrenoceptor agonists and blockers of voltage-gated calcium channels have been attributed antinociceptive activity, but only few studies have investigated their influence on the haemodynamic parameters. This study was performed to examine the changes in the mean arterial blood pressure (MAP) after intrathecal (i.t.) co-administration of morphine or clonidine with drugs blocking L- or N-type voltage gated calcium channels (verapamil and omega-conotoxin MVIIA, respectively) in anaesthetized rats. Lower doses of clonidine (0.01-5 microg i.t.) produced dose-dependent decreases in MAP, while the highest dose of clonidine (20 microg i.t.) produced a pressor response. The administration of morphine (0.01-20 microg i.t.) caused only minor decreases of blood pressure and these appeared not to be dose dependent. Both omega-conotoxin MVIIA (1 ng-10 microg i.t.) and verapamil (1-100 microg i.t.) at higher doses decreased blood pressure significantly. Omega-conotoxin MVIIA caused a sustained decrease in MAP, while the effect of verapamil was short-lasting. Co-administration of morphine with verapamil or omega-conotoxin MVIIA led to dose-dependent and sustained decreases in blood pressure. The co-administration of omega-conotoxin MVIIA with clonidine did not influence the effect of clonidine significantly. In contrast, the combination of higher doses of verapamil with clonidine caused far greater blood pressure decreases than saline, verapamil or clonidine treatments alone. These data suggest that the calcium channel blockers differentially influence the cardiovascular effect of the well-known antinociceptive drugs morphine and clonidine after intrathecal co-administration.

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The differential distribution and relationship of serotoninergic and peptidergic fibers to sympathoadrenal neurons in the intermediolateral cell column of the rat: A combined retrograde axonal transport and immunofluorescence study

Cited by 201 publications

References 70 publications

Distribution of dopamine immunoreactivity in the rat, cat, and monkey spinal cord

Distribution of dopamine immunoreactivity in the rat, cat, and monkey spinal cord

Neurochemistry of the paraventricular nucleus of the hypothalamus: Implications for cardiovascular regulation

Blood pressure changes after intrathecal co-administration of calcium channel blockers with morphine or clonidine at the spinal level

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