The Dimerisation of 5,6-Dimethoxy-Indene

Six sulfonamides derived from indanes and tetralines were synthesized. The human carbonic anhydrase isozymes hCA I and hCA II inhibition effects of the synthesized sulfonamides were determined. From these compounds, while N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl) methane sulfonamide showed the most potent inhibitory effect against hCA I (K i ¼ 46 AE 5.4 mM, r 2 ¼ 0.978), N-(1,2,3,4-tetrahydronaphthalene-2-yl)methanesulfonamide was found to have the best inhibitory effect against hCA II (K i ¼ 94 AE 7.6 mM, r 2 ¼ 0.982).

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The Dimerisation of 5,6-Dimethoxy-Indene

Abstract: The reaction of 5,6-dimethoxy-indanol with acids or with triphenylphosphine-carbon tetrachloride afforded several dimeric compounds; in the dimerisation of 5,6-dimethoxy-indene with SiO2–AgNO3 only a single dimer was obtained.

Cited by 3 publications

References 4 publications

The Dimerization of 5,6‐Dimethoxy‐indene.

The Dimerization of 5,6‐Dimethoxy‐indene.

Synthesis of naphthalene and indene precursors to naphthoic and indenoic acids

Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins

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