The direct ethanol metabolite ethyl glucuronide: A specific marker of recent alcohol consumption

Wurst, Friedrich Martin; Metzger, Joerg; Jachau, Katja; Seidl, S.; Pridzun, Lutz; Janda, Ines; Alt, Andreas

doi:10.1007/978-3-642-96008-6_5

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…The importance of this new marker is demonstrated by an increasing number of publications and the use of ethyl glucuronide by therapists, forensic toxicologists, judges and by our results from the WHO/ISBRA study on biological state and trait markers of alcohol use and dependence. 29,42,43 The complementary use of this marker with a specific time frame of detection with other biological state markers such as fatty acid ethyl esters, 31,32,34 -36 HTOL/HIAA ratio and phosphatidyl ethanol can provide us with information on drinking patterns and should lead, via the possibility of therapeutic intervention, to a significant improvement in treatment outcome, therapy effectiveness and cost reduction. Our preliminary data indicate that EtG excretion in urine is not random.…”

Section: Discussionmentioning

confidence: 99%

Ethyl glucuronide: on the time course of excretion in urine during detoxification

et al. 2002

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Ethyl glucuronide (EtG) is a promising new biological state marker of recent alcohol consumption that detects alcohol use reliably over a definite time period. Other currently available markers lack acceptable sensitivity and specificity. Our aim is to elucidate under naturalistic conditions the time course of EtG excretion in urine following alcohol consumption and to show how this can be utilized for monitoring and prognosis in patients. There are no other existing data on this issue to date. One hundred and thirty-eight urine samples from 28 male alcohol withdrawal patients were drawn every 3-24 hours for up to 94 hours after hospitalization. Breath ethanol concentration (mean) at hospitalization was 900 mg/L. Patient age in years was 40.3 (mean). Determination of urine EtG was performed by gas chromatography/mass spectrometry (GC/MS) with deuterium-labelled EtG as an internal standard. The strongest correlations (p<0.01) were found between EtG determinations in the different patient when breath ethanol concentrations (BEC) were 0 and 48 hours after BEC=0 (r=0.747), EtG 24 and 48 hours after BEC=0 (r=0.872), and in the time frame of detection (hours) of EtG and EtG 48 hours after BEC=0 (r=0.762). No significant correlation was found (Mann-Whitney test) between EtG concentrations in urine at different time points between the groups of patients with (a) 1 or less-2, (b) 3-4 or more previous hospitalizations, (c) a history of seizures (yes/no) or (d) an age above or below the median (40.5). EtG excretion in urine is not random, but seems rather to follow a kinetic profile. Furthermore our preliminary data indicate, that there is no significant difference for EtG concentration in urine when correlated to group variables such as age, seizures and hospitalizations.

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Section: Discussionmentioning

confidence: 99%

Ethyl glucuronide: on the time course of excretion in urine during detoxification

et al. 2002

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“…However, because the EtG is small (molecular weight of 222 g/mol) it is difficult to create an antibody. Nevertheless, the first immunization of two BALB/c mice with one lipopeptide conjugate-first fusion (after 7 weeks) of the spleen of one immunized mouseproduced one positive, a second fusion (after 15 weeks) of the second mouse resulted in 10 positive clones (Wurst et al . 2001).…”

Section: Future Perspective: Elisamentioning

confidence: 99%

Ethyl glucuronide—the direct ethanol metabolite on the threshold from science to routine use

2003

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The data suggest that EtG is a useful tool in numerous settings, including alcohol and drug treatment (to detect lapse/relapse and for motivational feedback), in safety sensitive work settings where use is dangerous or in other settings where alcohol use may be risky (e.g. such as driving, work-place, pregnancy or monitoring physicians or other professionals who are in recovery and working) or for resolving forensic questions. If the question of recent alcohol consumption has to be answered in a binary way (yes/no), such as for determining lapses. the use of EtG in urine is among the preferred tests. The use of this marker alone and complementary with other biological state markers and self-reports is expected to lead to significant improvement in treatment outcome, therapy efficacy and cost reduction.

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“…• ethyl glucuronide (EtG) (Schmitt et al . 1995; Wurst et al . 1999a,b, 2000, 2002, 2003a,b, 2004b; Alt et al .…”

Section: Introductionmentioning

confidence: 99%

Ethyl sulphate: a direct ethanol metabolite reflecting recent alcohol consumption

et al. 2005

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The direct ethanol metabolite ethyl glucuronide: A specific marker of recent alcohol consumption

Cited by 7 publications

References 12 publications

Ethyl glucuronide: on the time course of excretion in urine during detoxification

Ethyl glucuronide: on the time course of excretion in urine during detoxification

Ethyl glucuronide—the direct ethanol metabolite on the threshold from science to routine use

Ethyl sulphate: a direct ethanol metabolite reflecting recent alcohol consumption

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