The Disease with a Thousand Faces and the Human Microbiome—A Physiopathogenic Intercorrelation in Pediatric Practice

Lupu, Vasile Valeriu; Butnariu, Lacramioara Ionela; Fotea, Silvia; Morariu, Ionela Daniela; Badescu, Minerva Codruta; Starcea, Iuliana Magdalena; Salaru, Delia Lidia; Popp, Alina; Dragan, Felicia; Lupu, Ancuta; Mocanu, Adriana; Chisnoiu, Tatiana; Pantazi, Alexandru Cosmin; Jechel, Elena

doi:10.3390/nu15153359

Cited by 12 publications

(5 citation statements)

References 111 publications

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“…The pathogenic bases of the association are most likely aimed at immune and microbial imbalances, common to the three pathologies ( 203 , 204 ). Similar implications can be observed in the case of the association CD - systemic lupus erythematosus, a condition in the etiology of which we also find dysbiosis ( 205 ). Therefore, a number of autoimmunities can overlap in some situations, being included in the multiple autoimmune syndrome (MAS).…”

Section: Atypical Forms Of Celiac Diseasesupporting

confidence: 88%

Celiac disease - a pluripathological model in pediatric practice

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

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Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially in pediatrics, celiac disease (also called gluten enteropathy), is gaining more and more ground in terms of diagnosis, but also interest in research. The data from the literature of the last decades attest the chameleonic way of its presentation, there may be both classic onset symptoms and atypical symptoms. Given the impact played by celiac disease, especially in the optimal growth and development of children, the current narrative review aims to highlight the atypical presentation methods, intended to guide the clinician towards the inclusion of the pathology in the differential diagnosis scheme. To these we add the summary presentation of the general data and therapeutic lines regarding the underlying condition and the existing comorbidities. In order to place the related information up to date, we performed a literature review of the recent articles published in international databases. We bring forward the current theories and approaches regarding both classic celiac disease and its atypical manifestations. Among these we note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, but also disorders of biological constants and association with multiple autoimmunities. Knowing and correlating them with celiac disease is the key to optimal management of patients, thus reducing the subsequent burden of the disease.

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Section: Atypical Forms Of Celiac Diseasesupporting

confidence: 88%

Celiac disease - a pluripathological model in pediatric practice

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

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“…Finally, associations between microbiota composition and digestive disorders such as esophageal cancer, gastritis, celiac disease, Helicobacter pylori infection, and systemic lupus erythematosus was found [ 131 , 132 , 133 , 134 , 135 , 136 , 137 ].…”

Section: Conventional Treatment For Mitigating Dysbiosis In Infantsmentioning

confidence: 99%

Development of Gut Microbiota in the First 1000 Days after Birth and Potential Interventions

Pantazi,

Balasa,

Mihai

et al. 2023

Nutrients

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The first 1000 days after birth represent a critical window for gut microbiome development, which is essential for immune system maturation and overall health. The gut microbiome undergoes major changes during this period due to shifts in diet and environment. Disruptions to the microbiota early in life can have lasting health effects, including increased risks of inflammatory disorders, autoimmune diseases, neurological disorders, and obesity. Maternal and environmental factors during pregnancy and infancy shape the infant gut microbiota. In this article, we will review how maintaining a healthy gut microbiome in pregnancy and infancy is important for long-term infant health. Furthermore, we briefly include fungal colonization and its effects on the host immune function, which are discussed as part of gut microbiome ecosystem. Additionally, we will describe how potential approaches such as hydrogels enriched with prebiotics and probiotics, gut microbiota transplantation (GMT) during pregnancy, age-specific microbial ecosystem therapeutics, and CRISPR therapies targeting the gut microbiota hold potential for advancing research and development. Nevertheless, thorough evaluation of their safety, effectiveness, and lasting impacts is crucial prior to their application in clinical approach. The article emphasizes the need for continued research to optimize gut microbiota and immune system development through targeted early-life interventions.

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“…Initiated into clinical practice for the treatment of Clostridium difficile infection, transplantation of large feces is garnering increasing interest for the treatment of autoimmune diseases and intestinal dysbiosis [ 52 , 106 ]. Fecal microbiota transplantation (FMT) is an effective approach to restoring the diversity and structure of the microbiota by transferring healthy gut microbiota to recipients.…”

Section: Microbiota Modulatory Therapies In Ckd Patientsmentioning

confidence: 99%

Exploring a Complex Interplay: Kidney–Gut Axis in Pediatric Chronic Kidney Disease

Mocanu,

Bogos,

Lazaruc

et al. 2023

Nutrients

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The human intestinal microbiota is a highly intricate structure with a crucial role in promoting health and preventing disease. It consists of diverse microbial communities that inhabit the gut and contribute to essential functions such as food digestion, nutrient synthesis, and immune system development. The composition and function of the gut microbiota are influenced by a variety of factors, including diet, host genetics, and environmental features. In pediatric patients, the gut microbiota is particularly dynamic and vulnerable to disruption from endogenous and exogenous factors. Recent research has focused on understanding the interaction between the gut and kidneys. In individuals with chronic kidney disease, there is often a significant disturbance in the gut microbiota. This imbalance can be attributed to factors like increased levels of harmful toxins from the gut entering the bloodstream, inflammation, and oxidative stress. This review looks at what is known about the link between a child’s gut–kidney axis, how dysbiosis, or an imbalance in the microbiome, affects chronic kidney disease, and what treatments, both pharmaceutical and non-pharmaceutical, are available for this condition.

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The Disease with a Thousand Faces and the Human Microbiome—A Physiopathogenic Intercorrelation in Pediatric Practice

Cited by 12 publications

References 111 publications

Celiac disease - a pluripathological model in pediatric practice

Celiac disease - a pluripathological model in pediatric practice

Development of Gut Microbiota in the First 1000 Days after Birth and Potential Interventions

Exploring a Complex Interplay: Kidney–Gut Axis in Pediatric Chronic Kidney Disease

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