The distribution and chemical coding of enteroendocrine cells in Trypanosoma cruzi-infected individuals with chagasic megacolon

In focus in HCB

“…Chronic inflammatory conditions of the colon have been shown to affect the enteroendocrine cell population (El-Salhy et al 2012;De Jonge et al 2003). In their present work, Martins et al (2021) have applied immunohistochemistry to detect enteroendocrine cells positive for chromogranin A (CgA), glucagon-like peptide 1 (GLP-1), 5-hydroxytryptamine (5-HT), peptide YY (PYY) and somatostatin (SST) in the dilated and non-dilated portion of T. cruzi-induced megacolon and in non-infected individuals. They observed an increase in enteroendocrine cells expressing GLP-1 and SST in the dilated portion compared to the non-dilated portion of the same patients and in control colon (Fig.…”

“…Glucagon-like peptide (GLP-1) and somatostatin (SST) positive cells are significantly increased in the dilated portion as compared to non-dilated portion of chagasic megacolon. From Martins et al (2021) Fig. 3 The neuronal network in the ventral horn of the mouse spinal cord as visualized by a modified Golgi-Cox method (left) and its 3D-rendering by synchrotron radiation micro-computed tomography (right).…”