The distribution and physiological action of the suprarenal medullary tissue in petromyzon fluviatilis

Gaskell, J. F.

doi:10.1113/jphysiol.1912.sp001502

Cited by 42 publications

(11 citation statements)

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“…Giacomini (1902) and Gaskell (1912) observed chromaffin cells along the cardinal veins in Lampetra (Petromyzon), and Gaskell has described chromaffin cells in the wall of the sinus venosus. In the present investigation it was observed that there are cells in all parts of the heart which give a distinct chromaffin reaction.…”

Section: Distribution Of Nervous Elementsmentioning

confidence: 99%

Histological, physiological and biochemical studies on the heart of two cyclostomes, hagfish (Myxine) and lamprey (Lampetra)

Augustinsson¹,

Fänge²,

Johnels³

et al. 1956

The Journal of Physiology

117

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Section: Distribution Of Nervous Elementsmentioning

confidence: 99%

Histological, physiological and biochemical studies on the heart of two cyclostomes, hagfish (Myxine) and lamprey (Lampetra)

Augustinsson¹,

Fänge²,

Johnels³

et al. 1956

The Journal of Physiology

117

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“…First, in the heart of Lampetra fluvialis, Augustinsson et al (Augustinsson et al, 1956) re-described the granule-containing cells, i.e. the chromaffin cells, reported by Gaskell as early as 1912 (Gaskell, 1912). Johnels and Palmgren (Johnels and Palmgren, 1960) demonstrated their presence in the cyclostome (Myxine glutinosa) heart, which was shown to contain large amounts of CA (especially adrenaline) (Ostlund et al, 1960;von Euler and Fänge, 1961).…”

Section: Introductionmentioning

confidence: 99%

Catecholamines, cardiac natriuretic peptides and chromogranin A: evolution and physiopathology of a ‘whip-brake’ system of the endocrine heart

Tota

Cerra

Gattuso

2010

Journal of Experimental Biology

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Summary In the past 50 years, extensive evidence has shown the ability of vertebrate cardiac non-neuronal cells to synthesize and release catecholamines (CA). This formed the mindset behind the search for the intrinsic endocrine heart properties, culminating in 1981 with the discovery of the natriuretic peptides (NP). CA and NP, co-existing in the endocrine secretion granules and acting as major cardiovascular regulators in health and disease, have become of great biomedical relevance for their potent diagnostic and therapeutic use. The concept of the endocrine heart was later enriched by the identification of a growing number of cardiac hormonal substances involved in organ modulation under normal and stress-induced conditions. Recently, chromogranin A (CgA), a major constituent of the secretory granules, and its derived cardio-suppressive and antiadrenergic peptides, vasostatin-1 and catestatin, were shown as new players in this framework, functioning as cardiac counter-regulators in ‘zero steady-state error’ homeostasis, particularly under intense excitatory stimuli, e.g. CA-induced myocardial stress. Here, we present evidence for the hypothesis that is gaining support, particularly among human cardiologists. The actions of CA, NP and CgA, we argue, may be viewed as a hallmark of the cardiac capacity to organize ‘whip-brake’ connection-integration processes in spatio-temporal networks. The involvement of the nitric oxide synthase (NOS)/nitric oxide (NO) system in this configuration is discussed. The use of fish and amphibian paradigms will illustrate the ways that incipient endocrine-humoral agents have evolved as components of cardiac molecular loops and important intermediates during evolutionary transitions, or in a distinct phylogenetic lineage, or under stress challenges. This may help to grasp the old evolutionary roots of these intracardiac endocrine/paracrine networks and how they have evolved from relatively less complicated designs. The latter can also be used as an intellectual tool to disentangle the experimental complexity of the mammalian and human endocrine hearts, suggesting future investigational avenues.

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“…In these animals, in which there exists no adrenal medulla, the chromaffin cells form a subendothelial layer in the large blood vessels and the heart (GIACOMINI 1902(GIACOMINI , 1904GASKELL 1912). GASKELL also demonstrated the adrenaline-like biological activity of tissue extracts.…”

Section: Introductionmentioning

confidence: 91%

Observations on the chromaffin granules of the ventricle and the portal vein heart ofMyxine glutinosaL.

Helle

Lønning

Blaschko

1972

Sarsia

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The chromaffin granules present in the ventricle and the portal vein heart of the hagfish, Myxine glutinosa L., have been studied by electron microscopy, using for fixation a glutaraldehyde method which allows to distinguish between granules carrying either adrenaline or noradrenaline.From sections of fresh tissues as well as from particle fractions prepared by centrifugation of sucrose homogenates of the two hearts, pictures were obtained which confirm the presence of adrenaline in the granule-rich cells in the ventricle and of noradrenaline in the portal vein heart.Attention was also directed to granules, already noted by other observers, that occur in the myocardial cells adjoining the chromaffin cells. It was noted that both in the ventricle and in the portal vein heart these myocardial granules looked moderately electron dense, like adrenaline granules. Possible interpretations of these observations are discussed.

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The distribution and physiological action of the suprarenal medullary tissue in petromyzon fluviatilis

Cited by 42 publications

References 0 publications

Histological, physiological and biochemical studies on the heart of two cyclostomes, hagfish (Myxine) and lamprey (Lampetra)

Histological, physiological and biochemical studies on the heart of two cyclostomes, hagfish (Myxine) and lamprey (Lampetra)

Catecholamines, cardiac natriuretic peptides and chromogranin A: evolution and physiopathology of a ‘whip-brake’ system of the endocrine heart

Observations on the chromaffin granules of the ventricle and the portal vein heart ofMyxine glutinosaL.

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