The Diuretic Effect of Sairei-to Is Mediated by Nitric Oxide Production in Pentobarbital-Anesthetized Rats

Abstract

Abstract. Sairei-to (TJ-114), a Japanese traditional medicine, has been used clinically for the treatment of various edematous disorders. The inhibitory effect on edema may be dependent on the diuretic response to TJ-114. This study was conducted to clarify the mechanism of diuresis. Pentobarbital-anesthetized rats were infused with a saline solution intravenously (0.4 mL / 30 min). Urine was collected through a bladder cannula for 30 min. Intraduodenal administration of TJ-114 (0.5 -1.5 g / kg) resulted in a dose-dependent increase of urine volume with insignificant urinary sodium excretion and significant urea excretion, but no effect on mean arterial blood pressure. Furthermore, TJ-114 significantly increased urinary levels of NO 2 + NO 3 . In addition, intraperitoneal pre-treatment with 6 mg / kg of N G -nitro-L-arginine methyl ester inhibited the increase in urine volume, urinary urea excretion, and urinary levels of NO 2 + NO 3 in the rats treated with TJ-114. These results suggest that TJ-114 induces a diuretic response via production of NO.

Herbal medicines as diuretics: A review of the scientific evidence

“…All plant identified were confirmed using http://www.ipni.org. Some extracts [e.g., caffeine containing beverages, Passmore et al, 1987;Bergman et al, 1990;Neuhauser et al, 1997;Armstrong et al, 2005; flavonoids isolated from citrus fruit, Galati et al, 1996;Linoleic acid, Adam and Wolfram, 1984; and glycosides from the leaves of Stevia Rebaudiana, Melis and Sainati, 1991a,b;Melis, 1992aMelis, ,b,c, 1995Melis, , 1996Melis, , 1999 and extract decoctions [e.g., the Japanese traditional medicine known as Sairei-to (TJ-114), Fujitsuka et al, 2004, and the polyherbal preparation Jawarish Zarooni Sada, Afzal et al, 2004] were not included as they have no traditional uses in the treatment of urinary or cardiovascular ailments. Table 1 shows the plants identified using our search and indicates whether or not the plant has a traditional ethnopharmacological use.…”

The Effectiveness of Saireito, a Traditional Japanese Herbal Medicine, in Reducing Postoperative Edema after Acquired Ptosis Surgery: A Prospective Controlled Trial

“…The Japanese herbal medicine Saireito is a combination of two herbal medicines (Shosaikoto and Goreisan) that is used to treat inflammatory diseases as well as autoimmune diseases such as rheumatoid arthritis, cirrhosis, and nephrotic syndrome [ 4 – 7 ]. Saireito has also been demonstrated to be effective in treating edema after total hip arthroplasty and lymphedema after radiotherapy [ 8 , 9 ].…”

Therapeutic Effects of Saireito (Chai-Ling-Tang), a Traditional Japanese Herbal Medicine, on Lymphedema Caused by Radiotherapy: A Case Series Study

“…For example, Daikenchuto is effective on postoperative adhesive small bowel obstruction requiring long-tube decompression [10] and Goshajinkigan has been used for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer [11]. The Japanese herbal medicine Saireito (SRT) has been used empirically in the treatment of various edematous disorders (nephritic syndrome, cirrhosis, pregnancy, swelling, and lymphedema after surgery and macular edema) [12, 13]. It is composed of 12 crude drugs in fixed proportions: 7.0 g of Bupleurum root , 5.0 g of Pinellia tuber, 5.0 g of Alisma rhizome, 3.0 g of Scutellaria root, 3.0 g of ginseng, 3.0 g of Poria sclerotium, 3.0 g of Polypoms sclerotium, 3.0 g of Astractylodes lancea rhizome, 3.0 g of jujube, 2.0 g of Glycyrrhiza , 2.0 g of cinnamon bark, and 1.0 g of ginger.…”