The DNMT3B C→T promoter polymorphism and risk of breast cancer in a British population: a case-control study

Montgomery, Karen G.; Liu, Mira C.P.; Eccles, Diana; Campbell, Ian

doi:10.1186/bcr807

Cited by 78 publications

(60 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, in a case-control study of 352 cases and 258 controls in a British population, it was found that the DNMT3B -149 C alleles had a nominally significant increased risk of breast cancer compared with TT homozygotes [12]. In a Japanese study of 152 gastric cancer patients and 247 controls, it was reported that only the T/T genotype was detected in all case and control subjects [27].…”

Section: Discussionmentioning

confidence: 87%

“…Several case-control studies have been reported in which the association between the DNMT3B -149C>T polymorphism and risk of cancer was assessed [11][12][13][14]27,28]. However, the results from these molecular epidemiological studies are conflicting.…”

Section: Discussionmentioning

confidence: 94%

“…minor allele frequency (MAF) < 0.05) in European descents. It is reported that a single nucleotide polymorphism (SNP) -149C>T or C46359T (rs2424914) was significantly associated with both high promoter activity of DNMT3B and risk for several cancers in white populations [11][12][13][14]. However, another SNP -579G>T (rs2235758) was also associated with a higher promoter activity of DNMT3B, and it was associated with risk of lung cancer in an Asian population [15].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: A case–control study

et al. 2008

View full text Add to dashboard Cite

DNA-methyltransferase-3B (DNMT3B) may play an oncogenic role during tumorigenesis, and its genetic variants have been reportedly to be associated with risk of several cancers, but few studies have investigated their roles in head and neck cancer. Here we report a hospital-based case-control study with 832 SCCHN patients and 843 cancer-free controls of non-Hispanic whites that evaluated the association between two DNMT3B single nucleotide polymorphisms (SNPs) DNMT3B-149C>T (rs2424913) and DNMT3B-579G>T (rs2424909) in the promoter region and risk of squamous cell carcinoma of the head and neck (SCCHN). We found that compared with C-allele carriers, the DNMT3B-149 TT genotype was statistically significantly associated with increased risk of SCCHN (adjusted OR, 1.35, 95% CI, 1.01-1.80, P = 0.043), whereas the DNMT3B-579 TT genotype showed only a non-statistically significant risk compared with G-allele carriers. Further analysis of the effects of combined genotypes suggested that subjects with either DNMT3B-149 TT or DNMT3B-579 TT homozygous genotypes had statistically significantly increased risk of SCCHN (adjusted OR = 1.36, 95% CI = 1.07-1.73, P = 0.013). Stratification analysis showed a more profound risk in the subgroups of the young (≤57 years, the median age of the controls), males, current smokers, current drinkers, and patients with primary tumor sites of pharynx and larynx. This large study provides reliable risk estimates for associations between DNMT3B variants and SCCHN risk in non-Hispanic whites, and our findings are consistent with that of previously reported cancer case-control studies of other cancers. Further mechanistic studies are needed to unravel the underlying molecular mechanisms.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: A case–control study

et al. 2008

View full text Add to dashboard Cite

show abstract

“…A genetic deficiency of DNMT3B causes a recessive human disorder characterized by immunodeficiency, centromere instability, and facial anomalies (32). In case-control studies, variants in other DNMTs (i.e., DNMT3L, DNMT1) have been associated with cancers (33)(34)(35)(36).…”

Section: Genetic Factors That Influence Dna Methylationmentioning

confidence: 99%

Prospects for Epigenetic Epidemiology

Foley¹,

Craig²,

Morley³

et al. 2008

American Journal of Epidemiology

220

162

View full text Add to dashboard Cite

“…Genomewide association studies have shown that many susceptibility polymorphisms of genes are associated with breast cancer. Variants of DNMTs have been evaluated to determine relationships between DNMT polymorphisms and breast cancer risk (Montgomery et al, 2004;Cebrian et al, 2006;Ye et al, 2010;Xiang et al, 2010), but the results have been inconsistent. This study was performed to assess the association between single nucleotide polymorphisms (SNPs) in DNMTs and the risk for breast cancer among Han Chinese women from South China.…”

Section: Introductionmentioning

confidence: 99%

Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China

Sun¹,

Yang²,

Xu³

et al. 2012

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Patterns of DNA methylation are established and maintained by a family of DNA methyltransferases (DNMTs). Aberrant promoter DNA methylation of tumor suppressor genes is found in breast cancer. Association studies between DNMT gene polymorphisms and breast cancer in various populations have reported inconsistent results. This study assessed the associations of single nucleotide polymorphisms (SNPs) in DNMT1, DNMT3A, DNMT3B, DNMT3L, and DNMT2 with breast cancer among Han Chinese women from South China. Sixteen SNPs (rs2114724, rs2228611, rs2228612, rs8101866, and rs16999593 in DNMT1; rs13420827, rs11887120, rs13428812, rs1550117, rs11695471, and rs6733301 in DNMT3A; rs2424908, rs2424913, and rs6087990 in DNMT3B; rs113593938 in DNMT3L, and rs11254413 in DNMT2) in 408 women with breast cancer and 469 controls were genotyped using a MassARRAY matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry platform. Two SNPs, Polymorphisms of DNMT1 and DNMT3B and breast cancer risk rs16999593 in DNMT1 and rs2424908 in DNMT3B, were significantly associated with breast cancer risk. The heterozygous genotype CT of rs16999593 was associated with increased breast cancer risk [odds ratio (OR) = 1.60; 95% confidence interval (95%CI) = 1.20-2.14; P = 0.0052], whereas rs2424908 was associated with decreased risk (OR = 0.62; 95%CI = 0.46-0.84; P = 0.0061). Other DNMT polymorphisms showed no significant associations with breast cancer risk in the study population. Haplotype CGTC of rs2114724, rs2228611, rs8101866, and rs16999593 in DNMT1 differed significantly as a risk factor between the case and control groups (OR = 1.51; 95%CI = 1.18-1.93; P = 0.0012). The heterozygous genotypes of rs16999593 in DNMT1 and rs2424908 in DNMT3B were strongly associated with breast cancer risk.

show abstract

The DNMT3B C→T promoter polymorphism and risk of breast cancer in a British population: a case-control study

Cited by 78 publications

References 18 publications

Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: A case–control study

Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: A case–control study

Prospects for Epigenetic Epidemiology

Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China

Contact Info

Product

Resources

About