The dopamine antagonist flupentixol does not alter ghrelin-induced food intake in rats

Engster, Kim-Marie; Wismar, Jamina; Kroczek, Arthur L.; Teuffel, Pauline; Nolte, Sandra; Rose, Matthias; Stengel, Andreas; Kobelt, Peter

doi:10.1016/j.npep.2015.08.007

Cited by 4 publications

(1 citation statement)

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“…There were at least 72 h between injections with flupentixol and 48 h between injections with L-741626. The doses of L-741626 and flupentixol were based on previous studies in rats (Chaperon et al, 2003; Engster et al, 2015; Hiranita et al, 2013; Khaled et al, 2014; Veeneman et al, 2011;Wenzel et al, 2013).…”

Section: Methodsmentioning

confidence: 99%

The D1/D2-like receptor antagonist flupentixol and the D2-like receptor antagonist L-741626 decrease operant responding for nicotine and food and locomotor activity in male and female rats

et al. 2023

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Background: The reinforcing properties of nicotine play a critical role in smoking and vaping. There is a need for treatments that decrease the reinforcing properties of nicotine and thereby improve smoking and vaping rates. Dopamine plays a role in the reinforcing properties of nicotine, but little is known about the role of dopamine D2-like receptors in nicotine intake and whether there are sex differences in the effects of dopaminergic drugs on nicotine intake. Aim: The goal of the present studies was to investigate the effects of the D1/D2-like receptor antagonist flupentixol and the D2-like receptor antagonist L-741626 on nicotine self-administration in male and female rats. Methods: The effects of flupentixol and L-741626 on operant responding for nicotine and food and locomotor activity in a small open field were investigated. Results: There were no sex differences in baseline nicotine intake. The D1/D2-like receptor antagonist flupentixol and the D2-like receptor antagonist L-741626 decreased operant responding for nicotine. Blockade of D1/D2-like receptors and blockade of D2-like receptors also decreased operant responding for food and decreased locomotor activity. Flupentixol induced a greater decrease in operant responding for food in males than females. However, in the other tests, there were no sex differences in the effects of the dopamine receptor antagonists. Conclusions: Blockade of D1/D2-like receptors with flupentixol and D2-like receptors with L-741626 decreases nicotine and food intake in rats of both sexes. These compounds also decrease locomotor activity which might be indicative of a sedative effect.

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