The dopamine D1 receptor-rich main and paracapsular intercalated nerve cell groups of the rat amygdala: relationship to the dopamine innervation

Fuxé, Kjell; Jacobsen, Katja Kemp; Höistad, Malin; Tinner, B.; Jansson, Anders; Staines, W.A.; Agnati, Luigi F.

doi:10.1016/s0306-4522(03)00148-9

Cited by 84 publications

(88 citation statements)

References 45 publications

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“…Despite each ITC cluster receiving a relatively strong catecholaminergic innervation (TH-IR), as reported previously in rat (Fuxe et al, 2003;Muller et al, 2009) anesthesia (Abbott Laboratories). Brains were rapidly removed and placed in an ice-chilled artificial CSF (ACSF)-sucrose solution containing the following (in mM): 75 sucrose, 87 NaCl, 2.5 KCl, 0.5 CaCl 2 , 7 MgCl 2 , 1.25 NaH 2 PO 4 , 25 NaHCO 3 , and 25 glucose (VWR International), pH 7.3 (saturated with 95% O 2 , 5% CO 2 ).…”

Section: Acute Slice Preparation Electrophysiological Recordings Ansupporting

confidence: 58%

Different Fear States Engage Distinct Networks within the Intercalated Cell Clusters of the Amygdala

Busti¹,

Geracitano²,

Whittle³

et al. 2011

J. Neurosci.

124

163

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Section: Acute Slice Preparation Electrophysiological Recordings Ansupporting

confidence: 58%

Different Fear States Engage Distinct Networks within the Intercalated Cell Clusters of the Amygdala

Busti¹,

Geracitano²,

Whittle³

et al. 2011

J. Neurosci.

124

163

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“…Continued structural analysis, using double immunolabeling receptor and immunohistochemistry or transmitter histochemistry together with receptor autoradiography, has given evidence for the frequent existence of long-distance transmitter/receptor mismatches (topological mismatches) in the monoamine and peptide systems (see Herkenham, 1987;Fuxe et al, 1988bFuxe et al, , 2003bZoli et al, 1989;Bunnemann et al, 1991;Ferré et al, 1996;Jansson et al, 1998Jansson et al, , 1999Jansson et al, , 2001Jansson et al, , 2002Schwartz et al, 1998;Caberlotto et al, 1998;Fuxe et al, 2005;Jacobsen et al, 2006). Such observations strongly indicate the existence of long-distance VT in the brain.…”

Section: Location Of Transmitter Receptors Outside the Postsynaptic Dmentioning

confidence: 99%

“…This is particularly true for the dopamine D1 and D3 receptor mismatch compartments in nerve cell populations of the nucleus accumbens shell, the intercalated islands of the amygdala and the islands of Calleja surrounded by DA nerve terminal plexa (Diaz et al, 1995;Jansson et al, 1999;Fuxe et al, 2003bFuxe et al, , 2005. It now seems clear that transmitter-receptor mismatch is the architecture of volume transmission.…”

Section: Location Of Transmitter Receptors Outside the Postsynaptic Dmentioning

confidence: 99%

From the Golgi–Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: Wiring and volume transmission

Fuxé¹,

Dahlström²,

Höistad³

et al. 2007

Brain Research Reviews

234

219

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After Golgi-Cajal mapped neural circuits, the discovery and mapping of the central monoamine neurons opened up for a new understanding of interneuronal communication by indicating that another form of communication exists. For instance, it was found that dopamine may be released as a prolactin inhibitory factor from the median eminence, indicating an alternative mode of dopamine communication in the brain. Subsequently, the analysis of the locus coeruleus noradrenaline neurons demonstrated a novel type of lower brainstem neuron that monosynaptically and globally innervated the entire CNS.Furthermore, the ascending raphe serotonin neuron systems were found to globally innervate the forebrain with few synapses, and where deficits in serotonergic function appeared to play a major role in depression. We propose that serotonin reuptake This will lead to the unified execution of information handling and trophism for optimal brain function and survival.

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“…The BLA projects to the CeA and to the paracapsular intercalated cell masses, which are GABAergic and located at the medial border of the BLA (Royer et al, 1999). The intercalated cell masses and paracapsular neurons express high levels of D1 receptors and are also regulated by inputs from the prefrontal cortex and by catacholamines (Fuxe et al, 2003;Marowski et al, 2005). Ultimately, this provides feed forward inhibition of neurons in the CeA that is modulated by cortical inputs and catacholamines.…”

Section: Bdnf In Animal Models Of Anxiety Depression and Addictionmentioning

confidence: 99%

Ethanol–BDNF interactions: Still more questions than answers

Davis

2008

Pharmacology & Therapeutics

128

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Brain Derived Neurotrophic Factor (BDNF) has emerged as a regulator of development, plasticity and, recently, addiction. Decreased neurotrophic activity may be involved in ethanol-induced neurodegeneration in the adult brain and in the etiology of alcohol-related neurodevelopmental disorders. This can occur through decreased expression of BDNF or through inability of the receptor to transduce signals in the presence of ethanol. In contrast, recent studies implicate region-specific up-regulation of BDNF and associated signaling pathways in anxiety, addiction and homeostasis after ethanol exposure. Anxiety and depression are precipitating factors for substance abuse and these disorders also involve region-specific changes in BDNF in both pathogenesis and response to pharmacotherapy. Polymorphisms in the genes coding for BDNF and its receptor TrkB are linked to affective, substance abuse and appetitive disorders and therefore may play a role in the development of alcoholism. This review summarizes historical and pre-clinical data on BDNF and TrkB as it relates to ethanol toxicity and addiction. Many unresolved questions about region-specific changes in BDNF expression and the precise role of BDNF in neuropsychiatric disorders and addiction remain to be elucidated. Resolution of these questions will require significant integration of the literature on addiction and comorbid psychiatric disorders that contribute to the development of alcoholism.

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The dopamine D1 receptor-rich main and paracapsular intercalated nerve cell groups of the rat amygdala: relationship to the dopamine innervation

Cited by 84 publications

References 45 publications

Different Fear States Engage Distinct Networks within the Intercalated Cell Clusters of the Amygdala

Different Fear States Engage Distinct Networks within the Intercalated Cell Clusters of the Amygdala

From the Golgi–Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: Wiring and volume transmission

Ethanol–BDNF interactions: Still more questions than answers

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