The Dorsal Subiculum Mediates the Acquisition of Conditioned Reinstatement of Cocaine-Seeking

Martin‐Fardon, Rémi; Ciccocioppo, Roberto; Aujla, Harinder; Weiss, Friedbert

doi:10.1038/sj.npp.1301589

Cited by 16 publications

(12 citation statements)

References 61 publications

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“…Stimulation of the ventral subiculum can prompt drug seeking in rats (112), whereas the dorsal (but not ventral) subiculum plays a significant role in the reinstatement of cocaine seeking by cocaine itself (113). Separate influences of the amygdala and hippocampus on drug seeking (114) are yet to be established in humans.…”

Section: Discussionmentioning

confidence: 99%

The Neural Basis of Drug Stimulus Processing and Craving: An Activation Likelihood Estimation Meta-Analysis

Chase

Eickhoff

Laird

et al. 2011

Biological Psychiatry

296

264

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Background The capacity of drug cues to elicit drug-seeking behavior is believed to play a fundamental role in drug dependence; yet the neurofunctional basis of human drug cue-reactivity is not fully understood. We performed a meta-analysis to identify brain regions that are consistently activated by presentation of drug cues. Studies involving treatment-seeking and nontreatment-seeking substance users were contrasted to determine whether there were consistent differences in the neural response to drug cues between these populations. Finally, to assess the neural basis of craving, consistency across studies in brain regions that show correlated activation with craving was assessed. Methods Appropriate studies, assessing the effect of drug-related cues or manipulations of drug craving in drug-user populations across the whole brain, were obtained via the PubMed database and literature search. Activation likelihood estimation, a method of quantitative meta-analysis that estimates convergence across experiments by modeling the spatial uncertainty of neuroimaging data, was used to identify consistent regions of activation. Results Cue-related activation was observed in the ventral striatum (across both subgroups), amygdala (in the treatment-seeking subgroup and overall), and orbitofrontal cortex (in the nontreatment-seeking subgroup and overall) but not insula cortex. Although a different pattern of frontal and temporal lobe activation between the subgroups was observed, these differences were not significant. Finally, right amygdala and left middle frontal gyrus activity were positively associated with craving. Conclusions These results substantiate the key neural substrates underlying reactivity to drug cues and drug craving.

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Section: Discussionmentioning

confidence: 99%

The Neural Basis of Drug Stimulus Processing and Craving: An Activation Likelihood Estimation Meta-Analysis

Chase

Eickhoff

Laird

et al. 2011

Biological Psychiatry

296

264

View full text Add to dashboard Cite

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“…The subiculum also projects into the medial olfactory tubercle (Groenewegen et al, 1987). Given the olfactory tubercle’s place in the reward system (Heimer, 2003; Ikemoto, 2007a), this may provide an anatomical pathway for the involvement of the subiculum in reward behavior (Martin-Fardon et al, 2007). …”

Section: Interconnections Of the Tubercle With Other Regionsmentioning

confidence: 99%

Sniffing out the contributions of the olfactory tubercle to the sense of smell: Hedonics, sensory integration, and more?

Wesson

Wilson

2011

Neuroscience & Biobehavioral Reviews

177

182

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Since its designation in 1896 as a putative olfactory structure, the olfactory tubercle has received little attention in terms of elucidating its role in the processing and perception of odors. Instead, research on the olfactory tubercle has mostly focused on its relationship with the reward system. Here we provide a comprehensive review of research on the olfactory tubercle – with an emphasis on the likely role of this region in olfactory processing and its contributions to perception. Further, we propose several testable hypotheses regarding the likely involvement of the olfactory tubercle in both basic (odor detection, discrimination, parallel processing of olfactory information) and higher-order (social odor processing, hedonics, multi-modal integration) functions. Together, the information within this review highlights an understudied yet potentially critical component in central odor processing.

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“…Candidate regions within the brain that may be involved include the BLA, the dorsal hippocampus and subdivisions of the subiculum as recent studies indicate these brain areas as important nuclei involved in the acquisition and consolidation of cocaine-associated memories that maintain cocaine-seeking behavior [17,95,105,106,198,329]. Additional research indicates that new protein synthesis is necessary for the learning and consolidation of cocaine self-administration [216].…”

Section: Serotonergic Manipulations Of Cocaine-associated Memoriesmentioning

confidence: 99%

Serotonergic mechanisms in addiction-related memories

Dhonnchadha

Cunningham²

2008

Behavioural Brain Research

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Drug-associated memories are a hallmark of addiction and a contributing factor in the continued use and relapse to drugs of abuse. Repeated association of drugs of abuse with conditioned stimuli leads to long-lasting behavioral responses that reflect reward-controlled learning and participate in the establishment of addiction. A greater understanding of the mechanisms underlying the formation and retrieval of drug-associated memories may shed light on potential therapeutic approaches to effectively intervene with drug use-associated memory. There is evidence to support the involvement of serotonin (5-HT) neurotransmission in learning and memory formation through the families of the 5-HT1 receptor (5-HT1R) and 5-HT2R which have also been shown to play a modulatory role in the behavioral effects induced by many psychostimulants. While there is a paucity of studies examining the effects of selective 5-HT1AR ligands, the available dataset suggests that 5-HT1BR agonists may inhibit retrieval of cocaine-associated memories. The 5-HT2AR and 5-HT2CR appear to be integral in the strong conditioned associations made between cocaine and environmental cues with 5-HT2AR antagonists and 5-HT2CR agonists possessing potency in blocking retrieval of cocaine-associated memories following cocaine self-administration procedures. The complex anatomical connectivity between 5-HT neurons and other neuronal phenotypes in limbic-corticostriatal brain structures, the heterogeneity of 5-HT receptors (5-HTXR) and the conflicting results of behavioral experiments which employ non-specific 5-HTXR ligands contribute to the complexity of interpreting the involvement of 5-HT systems in addictive-related memory processes. This review briefly traces the history of 5-HT involvement in retrieval of drug-cue associations and future targets of serotonergic manipulation that may reduce the impact that drug cues have on addictive behavior and relapse.

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The Dorsal Subiculum Mediates the Acquisition of Conditioned Reinstatement of Cocaine-Seeking

Cited by 16 publications

References 61 publications

The Neural Basis of Drug Stimulus Processing and Craving: An Activation Likelihood Estimation Meta-Analysis

The Neural Basis of Drug Stimulus Processing and Craving: An Activation Likelihood Estimation Meta-Analysis

Sniffing out the contributions of the olfactory tubercle to the sense of smell: Hedonics, sensory integration, and more?

Serotonergic mechanisms in addiction-related memories

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