2018
DOI: 10.1186/s13014-018-1014-1
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The dose distribution in dominant intraprostatic tumour lesions defined by multiparametric MRI and PSMA PET/CT correlates with the outcome in patients treated with primary radiation therapy for prostate cancer

Abstract: BackgroundWe hypothesized that dominant intraprostatic lesions (DILs) could be depictured by multimodal imaging techniques (MRI and/or PSMA PET/CT) in patients with primary prostate cancer (PCa) and investigated possible effects of radiotherapy (RT) dose distribution within the DILs on the patients’ outcome.MethodsOne hundred thirty-eight patients with localized prostate cancer (PCa) and visible DIL underwent primary external beam RT between 2008 and 2016 with an aimed prescription dose of 76 Gy to the whole p… Show more

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Cited by 28 publications
(31 citation statements)
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“…This observation together with the failure to demonstrate significant differences in dosimetric parameters among BR and BC response groups when mpMRI-GTV is assumed as the responsible target could be explained by limitations of mpMRI to identify the true cancer volume in the prostate. As discussed by Zamboglou et al, a better predictor of the biochemical response is the union region defined by mpMRI and PSMA PET [5]. This is also supported by intra-individual comparison studies between mpMRI, PSMA PET and histopathology reference [37][38][39][40].…”
Section: Discussionmentioning
confidence: 60%
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“…This observation together with the failure to demonstrate significant differences in dosimetric parameters among BR and BC response groups when mpMRI-GTV is assumed as the responsible target could be explained by limitations of mpMRI to identify the true cancer volume in the prostate. As discussed by Zamboglou et al, a better predictor of the biochemical response is the union region defined by mpMRI and PSMA PET [5]. This is also supported by intra-individual comparison studies between mpMRI, PSMA PET and histopathology reference [37][38][39][40].…”
Section: Discussionmentioning
confidence: 60%
“…The Phoenix definition [9] for PSA relapse was used. Detailed description of CTV and PTV definition, of treatment technique and dose parameters for the total groups of patients are available in Zamboglou et al [5]. Regarding EBRT for the 129 patients, in 32% 3D-conformal and in 68% intensity-modulated RT (IMRT) was delivered as image-guided RT (IGRT) using daily 2D/2D imaging and at least one conebeam CT per week.…”
Section: A Patient Cohort and Treatmentmentioning
confidence: 99%
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“…Zamboglou et al delineated retrospectively the intraprostatic GTV based on mpMRI in patients with primary EBRT for PCa. The study could show that the dose distribution within the imaging-defined GTV correlates better with the biochemical recurrent free survival than the RT dose delivered to the rest of the prostatic gland [75]. Therefore, the ability of mpMRI to characterize the aggressiveness of the intraprostatic GTV requires further investigation.…”
Section: Mpmrimentioning
confidence: 99%