The DRD3 Ser9Gly Polymorphism Predicted Metabolic Change in Drug-Naive Patients With Bipolar II Disorder

Chang, Ting‐Ting; Chang, Yun-Hsuan; Chen, Po See; Chu, Chun-Hsien; Chen, Shih‐Heng; Huang, San-Yuan; Tzeng, Nian‐Sheng; Wang, Liang‐Jen; Wang, Tzu Yun; Li, Chia‐Ling; Chung, Yu-Chun; Hsieh, Tsai-Hsin; Lee, I‐Hui; Chen, Kao-Ching; Yang, Yue-Tzu; Hong, Jau–Shyong; Lu, Ru‐Band; Lee, Sheng-Yu

doi:10.1097/md.0000000000003488

Cited by 14 publications

(9 citation statements)

References 45 publications

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“…Interestingly, this variant has recently been also associated with low HDL levels in refractory schizophrenia (Pinto et al, 2018). Moreover, the most extensively DRD3 genetic variant (rs6280, also known as Ser9Gly) has been related to changes in TG and metabolic syndrome in treated patients with bipolar disorder (Chang et al, 2016). In our study, we found evidence for these two dopaminergic genes.…”

Section: Discussionsupporting

confidence: 63%

Association study of candidate genes with obesity and metabolic traits in antipsychotic-treated patients with first-episode psychosis over a 2-year period

et al. 2020

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Aims: Patients with a first episode of psychosis (FEP) often display different metabolic disturbances even independently of drug therapy. However, antipsychotic (AP) treatment, especially with second-generation APs, is strongly linked to weight gain, which increases patients’ risk of developing obesity and other metabolic diseases. There is an important genetic risk component that can contribute to the appearance of these disturbances. The aim of the present study was to evaluate the effect of polymorphisms in selected candidate genes on obesity and other anthropometric and metabolic traits in 320 AP-treated FEP patients over the course of a 2-year follow-up. Methods: These patients were recruited in the multicentre PEPs study (Phenotype−genotype and environmental interaction; Application of a predictive model in first psychotic episodes). A total of 127 validated single nucleotide polymorphisms (SNPs) in 18 candidate genes were included in the genetic analysis. Results: After Bonferroni correction, SNPs in ADRA2A, FTO, CNR1, DRD2, DRD3, LEPR and BDNF were associated with obesity, abdominal circumference, triglycerides, HDL cholesterol, and/or percentage of glycated haemoglobin. Conclusions: Although our results should be interpreted as exploratory, they support previous evidence of the impact of these candidate genes on obesity and metabolic status. Further research is required to gain a better knowledge of the genetic variants that can be considered relevant metabolic risk factors. The ability to identify FEP patients at higher risk for these metabolic disturbances would enable clinicians to better select and control their AP treatment.

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Section: Discussionsupporting

confidence: 63%

Association study of candidate genes with obesity and metabolic traits in antipsychotic-treated patients with first-episode psychosis over a 2-year period

et al. 2020

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“…[13] Presently, Ser9Gly polymorphisms are reported to be associated with acute pain in sickle cell disease, bipolar disorder, Parkinson's disease, and suicidical behaviors. [14][15][16][17] Recently, a number of molecular epidemiologic studies have addressed the association between Ser9Gly and schizophrenia risk. However, some reporters suggested that Ser9Gly was associated with the disease, [18,19] whereas the others found no association.…”

Section: Introductionmentioning

confidence: 99%

No association between the Ser9Gly polymorphism of the dopamine receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies

Li¹,

Zheng

Wei³

et al. 2020

Preprint

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Background: Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human dopamine receptor D3 gene (DRD3). It is still controversial whether Ser9Gly is involved in the occurrence of schizophrenia. While there has been meta-analysis performed previously, that work did not include the family-based studies, which accounted for stratification bias. Thus, we performed a meta-analysis of family-based studies to explore the role of Ser9Gly in the etiology of schizophrenia. Methods: The published family-based association studies were retrieved from the relevant literature databases according to the established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Moreover, subgroup analysis was carried out by ethnicity (i.e., East Asian, Caucasian, and other populations). Results: We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HRR) studies. There was no statistical significance for the heterogeneity in TDT and HRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that this association was significantly protective in East Asian in TDT studies (204 informative meiosis, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035). Conclusions: Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. These data provide possible avenues for future family-based studies related to schizophrenia.

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Section: Introductionmentioning

confidence: 99%

No association between the Ser9Gly polymorphism of the dopamine receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies

Zheng

Wei

et al. 2020

Preprint

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Background : Ser9Gly (rs6280) is a functional single nucleotide polymorphism (SNP) in the human dopamine receptor D3 gene ( DRD3 ) that may be involved in the occurrence of schizophrenia. We performed a meta-analysis of family-based studies to explore the role of Ser9Gly in the etiology of schizophrenia. Methods : The published family-based association studies were retrieved from the relevant literature databases according to the established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the strength of the relationship between Ser9Gly SNP and the occurrence of schizophrenia. Results : We finally pooled up 13 family-based association studies between Ser9Gly SNP and schizophrenia. It contained 11 transmission disequilibrium test (TDT) studies with 1219 informative meiosis and 5 haplotype-based haplotype relative risk (HHRR) studies. There was no statistical significance for the heterogeneity in TDT and HHRR studies. Therefore, the fixed effect model was used to measure the pooled effect size. The results showed that neither of the associations between Ser9Gly and the risk of schizophrenia were observed in TDT (1219 samples, OR=1.005, 95% CI = 0.898-1.125, Z-value = 0.086, p = 0.932) and HHRR studies (1704 samples, OR=0.869, 95% CI = 0.713-1.059, Z-value = -1.395, p = 0.163), except for the significantly preferential transmission of DRD3 Ser9 allele in East Asian in TDT studies (204 samples, OR=0.744, 95% CI = 0.564-0.980, Z-value = -2.104, p = 0.035). Conclusions : Our meta-analysis found no association between DRD3 gene Ser9Gly polymorphism and the risk of schizophrenia. These data provide possible avenues for future family-based studies related to schizophrenia.

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The DRD3 Ser9Gly Polymorphism Predicted Metabolic Change in Drug-Naive Patients With Bipolar II Disorder

Cited by 14 publications

References 45 publications

Association study of candidate genes with obesity and metabolic traits in antipsychotic-treated patients with first-episode psychosis over a 2-year period

Association study of candidate genes with obesity and metabolic traits in antipsychotic-treated patients with first-episode psychosis over a 2-year period

No association between the Ser9Gly polymorphism of the dopamine receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies

No association between the Ser9Gly polymorphism of the dopamine receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies

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