The driving system for hippocampal theta in the brainstem: An examination by single neuron recording in urethane-anesthetized rats

Takano, Yuji; Hanada, Yasuhiro

doi:10.1016/j.neulet.2009.03.028

Cited by 17 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, pedunculopontine stimulation induces prolonged neuronal activation in the pontine reticular neurons (Garcia‐Rill et al, ). The other theory, however, states that the RPO is the first element to start theta rhythm and the neurons in the PPN then maintain theta by activation of broad brainstem area that also participates in theta rhythm regulation (Kinney et al, ; Takano and Hanada, ). Yet another study indicates that RPO shows complete autonomy from the PPN in the case of theta elicited by carbachol injection into the RPO, but the RPO is functionally dependent on the PPN when it is electrical stimulation of the RPO that produces theta (Matulewicz et al, ).…”

Section: A Proposed Model Of Brainstem–vta–hippocampal Interactions Imentioning

confidence: 99%

Brainstem system of hippocampal theta induction: The role of the ventral tegmental area

Orzeł-Gryglewska

Matulewicz

Jurkowlaniec

2015

Synapse

View full text Add to dashboard Cite

This article summarizes the results of studies concerning the influence of the ventral tegmental area (VTA) on the hippocampal theta rhythm. Temporary VTA inactivation resulted in transient loss of the hippocampal theta. Permanent destruction of the VTA caused a long-lasting depression of the power of the theta and it also had some influence on the frequency of the rhythm. Activation of glutamate (GLU) receptors or decrease of GABAergic tonus in the VTA led to enhancement of dopamine release and increased hippocampal theta power. High time and frequency cross-correlation was detected for the theta band between the VTA and hippocampus during paradoxical sleep and active waking. Thus, the VTA may belong to the broad network involved in theta rhythm regulation. This article also presents a model of brainstem-VTA-hippocampal interactions in the induction of the hippocampal theta rhythm. The projections from the VTA which enhance theta rhythm are incorporated into the main theta generation pathway, in which the septum acts as the central node. The neuronal activity that may be responsible for the ability of the VTA to regulate theta probably derives from the structures associated with rapid eye movement (sleep) (REM) sleep or with sensorimotor activity (i.e., mainly from the pedunculopontine and laterodorsal tegmental nuclei and also from the raphe).

show abstract

Section: A Proposed Model Of Brainstem–vta–hippocampal Interactions Imentioning

confidence: 99%

Brainstem system of hippocampal theta induction: The role of the ventral tegmental area

Orzeł-Gryglewska

Matulewicz

Jurkowlaniec

2015

Synapse

View full text Add to dashboard Cite

show abstract

“…While the RPO is thought to be the main brain stem site involved in the generation of theta (Vertes and Kocsis 1997), the PPTg modulates RPO activity with direct cholinergic projections (Semba and Fibiger 1992;Shiromani et al 1988;Vertes and Kocsis 1997). The RPO is thought to trigger the onset of theta while the PPTg maintains it (Takano and Hanada 2009). Within the theta-generating pathway, the brain stem nuclei project to the SUM and the PH, which then projects to the medial septum/diagonal band of Broca (MS).…”

Section: Introductionmentioning

confidence: 99%

The modulation of hippocampal theta rhythm by the vestibular system

Aitken

Zheng

Smith

2018

Journal of Neurophysiology

View full text Add to dashboard Cite

The vestibular system is a sensory system that has evolved over millions of years to detect acceleration of the head, both rotational and translational, in three dimensions. One of its most important functions is to stabilize gaze during unexpected head movement; however, it is also important in the control of posture and autonomic reflexes. Theta rhythm is a 3- to 12-Hz oscillating EEG signal that is intimately linked to self-motion and is also known to be important in learning and memory. Many studies over the last two decades have shown that selective activation of the vestibular system, using either natural rotational or translational stimulation, or electrical stimulation of the peripheral vestibular system, can induce and modulate theta activity. Furthermore, inactivation of the vestibular system has been shown to significantly reduce theta in freely moving animals, which may be linked to its impairment of place cell function as well as spatial learning and memory. The pathways through which vestibular information modulate theta rhythm remain debatable. However, vestibular responses have been found in the pedunculopontine tegmental nucleus (PPTg) and activation of the vestibular system causes an increase in acetylcholine release into the hippocampus, probably from the medial septum. Therefore, a pathway from the vestibular nucleus complex and/or cerebellum to the PPTg, supramammillary nucleus, posterior hypothalamic nucleus, and septum to the hippocampus is likely. The modulation of theta by the vestibular system may have implications for vestibular effects on cognitive function and the contribution of vestibular impairment to the risk of dementia.

show abstract

“…On the structural level, the medial septum-diagonal band of Broca (MS-DBB) and the hippocampus emerged as the core substrate to trigger and maintain complex theta oscillations [ 20 , 21 , 22 , 23 , 24 , 25 ]. Although still under investigation, it has been proposed that the MS-DBB initiates theta oscillations in the septohippocampal system.…”

Section: Atropine-insensitive Type I and Atropine-sensitive Type Ii T...mentioning

confidence: 99%

Cav3 T-Type Voltage-Gated Ca2+ Channels and the Amyloidogenic Environment: Pathophysiology and Implications on Pharmacotherapy and Pharmacovigilance

Papazoglou

Arshaad

Henseler

et al. 2022

IJMS

View full text Add to dashboard Cite

Voltage-gated Ca2+ channels (VGCCs) were reported to play a crucial role in neurotransmitter release, dendritic resonance phenomena and integration, and the regulation of gene expression. In the septohippocampal system, high- and low-voltage-activated (HVA, LVA) Ca2+ channels were shown to be involved in theta genesis, learning, and memory processes. In particular, HVA Cav2.3 R-type and LVA Cav3 T-type Ca2+ channels are expressed in the medial septum-diagonal band of Broca (MS-DBB), hippocampal interneurons, and pyramidal cells, and ablation of both channels was proven to severely modulate theta activity. Importantly, Cav3 Ca2+ channels contribute to rebound burst firing in septal interneurons. Consequently, functional impairment of T-type Ca2+ channels, e.g., in null mutant mouse models, caused tonic disinhibition of the septohippocampal pathway and subsequent enhancement of hippocampal theta activity. In addition, impairment of GABA A/B receptor transcription, trafficking, and membrane translocation was observed within the septohippocampal system. Given the recent findings that amyloid precursor protein (APP) forms complexes with GABA B receptors (GBRs), it is hypothesized that T-type Ca2+ current reduction, decrease in GABA receptors, and APP destabilization generate complex functional interdependence that can constitute a sophisticated proamyloidogenic environment, which could be of potential relevance in the etiopathogenesis of Alzheimer’s disease (AD). The age-related downregulation of T-type Ca2+ channels in humans goes together with increased Aβ levels that could further inhibit T-type channels and aggravate the proamyloidogenic environment. The mechanistic model presented here sheds new light on recent reports about the potential risks of T-type Ca2+ channel blockers (CCBs) in dementia, as observed upon antiepileptic drug application in the elderly.

show abstract

The driving system for hippocampal theta in the brainstem: An examination by single neuron recording in urethane-anesthetized rats

Cited by 17 publications

References 30 publications

Brainstem system of hippocampal theta induction: The role of the ventral tegmental area

Brainstem system of hippocampal theta induction: The role of the ventral tegmental area

The modulation of hippocampal theta rhythm by the vestibular system

Cav3 T-Type Voltage-Gated Ca2+ Channels and the Amyloidogenic Environment: Pathophysiology and Implications on Pharmacotherapy and Pharmacovigilance

Contact Info

Product

Resources

About