The dry powder inhaler features of the Easyhaler that benefit the management of patients

Abstract

Introduction: Inhaled therapies are likely to continue to dominate asthma and chronic obstructive pulmonary disease treatment. Dry powder inhalers (DPIs) have several advantages over pressurized metered-dose inhaler (pMDIs), that are most frequently marketed world-wide, but often difficult to use. This literature search focus on DPI features, with respect to Easyhaler, that may affect their use and patients' clinical benefit. Areas covered: DPIs are breath-actuated, easy to use, convenient to use, and more environmentally friendly. During inhalation, the formulation in a DPI is disaggregated by a turbulent airflow energy to generate particles with the greatest likelihood of deposition into the airways. The resistance among DPIs varies from low to high and those with high resistance are wrongly considered as difficult to use. Multidose reservoir-type DPIs have been developed to efficiently deliver a wide range of medications, including the fixed-dose combination of budesonide and formoterol. Easyhaler® shares a similar shape with pMDIs and, as other DPIs, its performance is unaffected by environmental and storage conditions. Due to Easyhaler internal design, dose emission is consistent irrespective of the inhalation flow used by each patient. Expert opinion: Easyhaler® may be considered one of the most convenient inhalers, for daily use, in patients with asthma or COPD.

Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential

“…Inhalation devices have a significant impact on the inhaled dose, efficacy and clinical effectiveness of DPI. With the improvement of micronization technology and the development of DPI devices, the inhalation device has developed from the original capsule type, vesicle type, to a reservoir type drug delivery device [ 150 , 151 ].…”

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“…Even healthcare professionals use DPIs inappropriately ( Plaza et al, 2018 ). Adequate training and instructions can ensure the proper use and performance of the DPIs to ensure maximum therapeutic outcomes ( Chrystyn and Lavorini, 2020 ).…”

Dry Powder Inhalers in the Digitalization Era: Current Status and Future Perspectives

“…Unfortunately, approximately 22–78% of patients with asthma and COPD and 31–53% of CF patients are poorly adherent to their inhaled medications [ 36 , 37 ]. Errors in inhalation techniques occur in a percentage of 6.8–43.2%, and only 10–52% of physicians are adequately informed regarding proper device use [ 38 , 39 ]. The most common clinically significant errors include incorrect positioning of both the device and the head, failure (i) to insert and pierce the capsule (for the capsule-based DPIs), (ii) to exhale away from the device prior to inhalation, (iii) to hold the breath after inhalation, and (iv) to maintain a forceful and deep inspiration.…”