2023
DOI: 10.20944/preprints202312.1804.v1
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The Dynamic Crosstalk between Gut Microbiota, Immune System, and Autophagy in the Onset of Inflammatory Bowel Disease: Molecular Mechanisms and Current Therapeutic Approaches

Beatrice Garavaglia,
Letizia Vallino,
Angela Amoruso
et al.

Abstract: The crosstalk between gut microbiota, intestinal epithelial cells, and innate and adaptive immune system governs the maintenance of the intestinal homeostasis. Any interference in this tight dialogue and in the processes preserving cellular homeostasis (e.g., autophagy) may dysregulate the immune response and impair the clearance of harmful bacteria favoring the dysbiotic alteration of the microbic flora that leads to chronic inflammation. Gut dysbiosis is strongly associated with gastrointestinal inflammatory… Show more

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