The dynamics of Poststroke depression among Ghanaians

Agbenorku, Manolo; Adamu, Sheila; Obese, Vida; Berchie, Patrick; Ovbiagele, Bruce; investigators, Pings Study

doi:10.1016/j.jns.2019.07.028

Cited by 8 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Secondary Prevention of Small Subcortical Strokes (SPS3) trial revealed that 19% of stroke patients suffered from post-stroke depression (PSD), while a meta-analysis of 51 observational studies estimates that one out of every three stroke survivors suffer from the PSD [ 9 , 10 ]. Patients with PSD have been shown to have poorer neurological outcomes, and its economic costs are staggering, affecting health systems at a global scale [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Understanding Why Post-Stroke Depression May Be the Norm Rather Than the Exception: The Anatomical and Neuroinflammatory Correlates of Post-Stroke Depression

Wijeratne

Sales

2021

JCM

View full text Add to dashboard Cite

Ischemic Stroke precedes depression. Post-stroke depression (PSD) is a major driver for poor recovery, negative quality of life, poor rehabilitation outcomes and poor functional ability. In this systematic review, we analysed the inflammatory basis of post-stroke depression, which involves bioenergetic failure, deranged iron homeostasis (calcium influx, Na influx, potassium efflux etc), excitotoxicity, acidotoxicity, disruption of the blood brain barrier, cytokine-mediated cytotoxicity, reactive oxygen mediated toxicity, activation of cyclooxygenase pathway and generation of toxic products. This process subsequently results in cell death, maladapted, persistent neuro-inflammation and deranged neuronal networks in mood-related brain regions. Furthermore, an in-depth review likewise reveals that anatomic structures related to post-stroke depression may be localized to complex circuitries involving the cortical and subcortical regions.

show abstract