The E27 β2-adrenergic Receptor Polymorphism Reduces the Risk of Myocardial Infarction in Dyslipidemic Young Males

Sala, G; Castelnuovo, Augusto Di; Cuomo, Laura; Gattone, Marinella; Giannuzzi, P; Iacoviello, Licia; A, De Blasi

doi:10.1055/s-0037-1615699

Cited by 13 publications

(14 citation statements)

References 11 publications

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“…Carriers of one or two copies of the Glu 27 allele had a decreased risk of developing MI compared with homozygote Gln27 subjects (OR 5 0.48, 95% CI 5 0.24-0.94, P 5 0.03) ( Table 3). In agreement with our findings, the ADRB2 Glu27 allele was shown to have a protective effect against MI in young dyslipidemic males (17). Moreover, in a study investigating the possible relationships between Arg16Gly and Gln27Glu b 2 -AR polymorphisms and the risk of cardiovascular events in older patients, homozygote carriers of the Gln27 allele were found to have a higher risk of coronoary events than Glu27 allele carriers.…”

Section: Resultssupporting

confidence: 90%

“…The Ser49Gly and Arg389Gly polymorphisms of ADRB1 have been associated with a number of phenotypes, mostly related to the cardiovascular system, including heart rate (5,6), heart failure (7-10), dilated cardiomyopathy (11,12), myocardial infarction (MI) (13), and hypertension (14), but with conflicting results. In addition to ADRB1 polymorphisms, the ADRB2 polymorphisms, Gly16Arg and Gln27Glu, have been evaluated in relation to several cardiovascular diseases, including hypertension (15,16), MI (15,(17)(18)(19)(20), andbeen studied in relation to idiopathic ventricular arrhythmias in a Turkish population (22).…”

Section: Introductionmentioning

confidence: 99%

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Association of β‐1 and β‐2 adrenergic receptor gene polymorphisms with myocardial infarction

Yılmaz

Kaya

Merdanoglu

et al. 2009

Clinical Laboratory Analysis

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Both beta(1)- and beta2-adrenergic receptors (beta(1)- and beta(2)-AR) have important roles in heart function mainly in response to catecholamines. Some specific polymorphisms in the beta(1)- and beta(2)-AR genes, named ADRB1 and ADRB2, respectively, have been implicated in several cardiovascular and noncardiovascular phenotypes. In this study, we aimed to investigate the possible relationship between Ser49Gly and Arg389Gly polymorphisms of the ADRB1 and Arg16Gly and Gln27Glu polymorphisms of the ADRB2 gene with ST elevation myocardial infarction (MI) in a Turkish population. One hundred patients with ST elevation MI and 100 healthy control subjects were genotyped using the PCR-RFLP method. Although the Arg389 allele of the ADRB1 gene was associated with an elevated risk of MI, the Glu27 allele of the ADRB2 gene was associated with a decreased risk of MI. Carriers of the ADRB1 Arg389 allele (heterozygotes+homozygotes) had an approximately 3.5-fold increased risk for MI than Gly389 homozygotes (OR=3.59, 95% CI=0.96-13.47, P=0.045). For the ADRB2 Gln27Glu polymorphism, subjects having one or two copies of the Glu27 allele showed a decreased risk of MI compared with Gln27 homozygote subjects (OR=0.48, 95% CI=0.24-0.94, P=0.03). Haplotype analysis of these polymorphisms showed no significant differences between groups. These results suggest that the Arg389Gly and Gln27Glu polymorphisms may be associated with an altered risk of MI in this Turkish population.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Association of β‐1 and β‐2 adrenergic receptor gene polymorphisms with myocardial infarction

Yılmaz

Kaya

Merdanoglu

et al. 2009

Clinical Laboratory Analysis

View full text Add to dashboard Cite

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“…Prior studies, however, are not in agreement on which specific variants of these polymorphisms are associated with enhanced vasodilation (Brodde, 2008b). Our findings are in line with earlier epidemiologic studies that support the protective effect of the Glu 27 allele on risks of MI, as documented both in longitudinal population-based studies (e.g., the Cardiovascular Health Study (Heckbert et al, 2003)) and in case-control studies (e.g., Sala et al, 2001). …”

Section: Discussionsupporting

confidence: 92%

Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context

Kulminski

Culminskaya

Ukraintseva

et al. 2010

Mechanisms of Ageing and Development

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“…This allele was also associated with increased BMI in Japanese males [9] and females ; and in those females it was also associated with increased triacylglycerol levels [9]. A relationship with an increased BMI in Swedish females, but not in Swedish males, has also been identified [7], while no association with obesity or Type II diabetes was found in young Danish males [12], Italian males [19], Black South Africans [14], Swedish males [18] and Austrian females [17]. Thus, although this polymorphism may have population-and gender-specific associations with obesity and Type II diabetes, its role remains unclear.…”

Section: Discussionmentioning

confidence: 95%

“…They found a marked association of this allele with obesity with an odds ratio of approx. 10 ; however, the results obtained in other populations have varied [7,[9][10][11][12][13][14][15][16][17][18][19][20]. Mindful of these diverse findings, we investigated the relationship of the Gln#(Glu polymorphism in the β # AR gene to obesity and Type II diabetes in a representative sample of the Tongan population.…”

Section: Introductionmentioning

confidence: 99%

Obesity, Type II diabetes and the β2 adrenoceptor gene Gln27Glu polymorphism in the Tongan population

et al. 2003

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As there is a high prevalence of obesity in Tonga, we aimed to determine the distribution of the beta2 adrenoceptor gene Gln(27)Glu polymorphism and to assess its relevance to obesity and to Type II diabetes, known to be prevalent in that population. A random sample of 1022 individuals from Tonga were genotyped for the Gln(27)Glu polymorphism in the beta 2 adrenoceptor gene. To assess the prevalence of obesity we measured body-mass index (BMI), fat-free mass, percentage fat and waist-to-hip ratio (WHR). To assess glucose metabolism we measured HbA(1c), fasting blood glucose, fasting serum insulin, and 1- and 2-h glucose; we also measured serum lipid and creatinine levels. We found that 84% of the Tongan men and 93% of the women were overweight or obese (BMI > or = 25 kg/m(2)) and 15.1% had Type II diabetes. Genotype frequencies among the 1022 Tongans were: Gln/Gln 90.3% and Gln/Glu 9.6%; we found one Glu/Glu homozygote. The mean BMI (+/-S.D.) for men was not significantly different for those who were homozygous (30.2+/-5.4 kg/m(2)) or heterozygous (30.1+/-5.5 kg/m(2)) for the Gln allele; this was also true for women (33.7+/-6.2 kg/m(2) for homozygous and 34.0+/-5.6 kg/m(2) for heterozygous). The Glu allele was not associated with other measures of obesity or abnormal glucose metabolism in this generally overweight population. There is a unique frequency of the Gln/Glu beta 2 adrenoceptor polymorphism among Tongans. We found no association of the polymorphism with obesity measures or Type II diabetes-related variables in the Tongan population among whom we documented a high prevalence of obesity and Type II diabetes and a low frequency of the Glu allele.

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The E27 β2-adrenergic Receptor Polymorphism Reduces the Risk of Myocardial Infarction in Dyslipidemic Young Males

Cited by 13 publications

References 11 publications

Association of β‐1 and β‐2 adrenergic receptor gene polymorphisms with myocardial infarction

Association of β‐1 and β‐2 adrenergic receptor gene polymorphisms with myocardial infarction

Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context

Obesity, Type II diabetes and the β2 adrenoceptor gene Gln27Glu polymorphism in the Tongan population

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