The Early-Life Exposome: Description and Patterns in Six European Countries

Tamayo, Ibón; Maitre, Léa; Thomsen, Cathrine; Nieuwenhuijsen, Mark; Siroux, Valérie; Chatzi, Leda; Slama, Rémy; Vrijheid, Martine; Basagaña, Xavier

doi:10.1289/isesisee.2018.p02.3310

Cited by 15 publications

(33 citation statements)

References 30 publications

(38 reference statements)

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“…In the HELIX project, due to the large number of exposures and low correlations observed between them, the exposome revealed to be high dimensional and difficult to summarize in a few principal components. Ten principal components explained 45% and 39% of the total variance in the pregnancy and childhood exposome, respectively, while 65 and 90 components were required to explain 95% of the exposome variability [19]. In studies using specific subsets of exposures, namely urban or chemical exposures, a reasonable number of principal components was obtained, reinforcing that summarizing the data might be easier for a smaller subset of exposures and within certain exposure families [15,18].…”

Section: Dimensionality Of the Exposomementioning

confidence: 99%

“…The selection of exposures to consider in the study depends on the research question and issues of feasibility and data accessibility. Previous studies have included a wide range of external environmental exposures from various families, or have been specifically focused on certain components of the exposome, such as the urban or the chemical exposome, assessed at various developmental periods [13][14][15][16][17][18][19]. Socioand public health exposome conceptual frameworks have also been proposed and can guide the selection of exposures [20,21].…”

Section: Selecting and Pre-processing Exposuresmentioning

confidence: 99%

“…The correlation structure of a large set of exposures has been described using data from the Spanish INMA birth cohort and from the US NHANES and LIFE studies [17,[33][34][35]. More recently, the HELIX project has also described the correlation structure of the exposome, using over 200 environmental exposures that were assessed in pregnant women and later in their children in 6 European birth cohorts [19]. In these previous studies, the correlation coefficients were stronger within than between families of exposures.…”

Section: Correlation Structure Of the Exposomementioning

confidence: 99%

“…Strong correlations between specific pairs of exposures from the same family were reported, although, particularly in the HELIX project, most correlations were low or moderate (the median correlation value observed within families was only 0.2). The exposome correlation structure seems also to vary across spatially and temporally distributed populations [19]. Thus, the exposures correlation structure needs to be evaluated in each exposome study, since it is largely influenced by the setting and by the set of exposures and exposure families included.…”

Section: Correlation Structure Of the Exposomementioning

confidence: 99%

“…Heat maps and circos plots have been developed to visually display the correlations [17,34,37]. Another tool to visualize the complex relations between exposures is a network analysis, in which exposures that are close together in the network are more correlated than more distant ones [19]. We should note that the correlation structure might be influenced by how the exposures were assessed or constructed and by the presence of measurement error.…”

Section: Correlation Structure Of the Exposomementioning

confidence: 99%

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Applying the exposome concept in birth cohort research: a review of statistical approaches

et al. 2020

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The exposome represents the totality of life course environmental exposures (including lifestyle and other non-genetic factors), from the prenatal period onwards. This holistic concept of exposure provides a new framework to advance the understanding of complex and multifactorial diseases. Prospective pregnancy and birth cohort studies provide a unique opportunity for exposome research as they are able to capture, from prenatal life onwards, both the external (including lifestyle, chemical, social and wider community-level exposures) and the internal (including inflammation, metabolism, epigenetics, and gut microbiota) domains of the exposome. In this paper, we describe the steps required for applying an exposome approach, describe the main strengths and limitations of different statistical approaches and discuss their challenges, with the aim to provide guidance for methodological choices in the analysis of exposome data in birth cohort studies. An exposome approach implies selecting, pre-processing, describing and analyzing a large set of exposures. Several statistical methods are currently available to assess exposome-health associations, which differ in terms of research question that can be answered, of balance between sensitivity and false discovery proportion, and between computational complexity and simplicity (parsimony). Assessing the association between many exposures and health still raises many exposure assessment issues and statistical challenges. The exposome favors a holistic approach of environmental influences on health, which is likely to allow a more complete understanding of disease etiology.

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Section: Dimensionality Of the Exposomementioning

confidence: 99%

Section: Selecting and Pre-processing Exposuresmentioning

confidence: 99%

Section: Correlation Structure Of the Exposomementioning

confidence: 99%

Section: Correlation Structure Of the Exposomementioning

confidence: 99%

Section: Correlation Structure Of the Exposomementioning

confidence: 99%

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Applying the exposome concept in birth cohort research: a review of statistical approaches

et al. 2020

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Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates

Ferguson

Zhao

et al. 2019

Environment International

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Background: Maternal exposure to environmental phenols is common in pregnancy and has been linked to preterm birth, preeclampsia, and reduced fetal growth. One potential mechanism may be through increased maternal oxidative stress. Objective: We examined the associations between a panel of 10 urinary phenols, including dich loro phenols, benzophenone-3, parabens, triclosan and triclocarban, and bisphenol-S, and two urinary oxidative stress biomarkers, 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane. All exposure and outcome biomarkers were measured at 4 time points in pregnancy. Methods: We used repeated measures models to examine the association between repeated exposure and outcome biomarkers. Additionally, we used adaptive elastic net (AENET) to identify non-null associations accounting for the correlation structure of exposures, both for phenols and urinary phthalate metabolites that were previously associated with the oxidative stress biomarkers in our study population. Results: In adjusted repeated measures models, we observed that dichlorophenols, benzophenone-3, triclosan, and some parabens were associated with increases in both oxidative stress biomarkers. The greatest effect estimates were observed for 2,5-dichlorophenol; an interquartile range (IQR) increase in this compound was associated with a 15.2% (95% confidence interval [CI] = 11.0, 19.6) increase in 8-OHdG and a 16.7% (95% CI = 9.66, 24.2) increase in 8-isoprostane. Bisphenol-S detection was associated with a clear increase in 8-isoprostane (18.5%, 95% CI = 7.68, 30.5) but a more modest increase in 8-OHdG (6.18%, 95% CI = −0.27, 13.1). However, AENET models did not consistently select any of the phenols as predictors of 8-OHdG or 8-isoprostane when phthalate metabolites were included in the model. Conclusion: Overall, urinary phenols were associated with increases in biomarkers of oxidative stress in pregnancy but either to a lesser extent, or due to correlation with, urinary phthalate metabolites.

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Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study

Maitre

Júlvez

López-Vicente

et al. 2021

Environment International

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The Early-Life Exposome: Description and Patterns in Six European Countries

Cited by 15 publications

References 30 publications

Applying the exposome concept in birth cohort research: a review of statistical approaches

Applying the exposome concept in birth cohort research: a review of statistical approaches

Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates

Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study

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