The ECM and CAFs interact to differentially regulate PDAC parenchymal (CPC) and CSC phenotypes to determine pancreatic ductal adenocarcinoma (PDAC) progression

Abstract

Summary CAFs and acellular stromal ECM components interact to drive metastatic progression by stimulating the hallmark behaviors of each tumor cell type that contribute to metastasis: invasion in the CPCs and growth and angiogenesis in the CSCs.