The Edinburgh Artery Study: is lytic activity bad for the heart?

Grant, P. J.

doi:10.1053/euhj.2000.2271

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…The European Concerted Action on Thrombosis (ECAT) study reported elevated levels of fibrinogen, von Willebrand factor, and tPA in patients in whom coronary events developed. 10 Another study 11 demonstrated a diurnal variation in endothelium-dependent vasodilatation with enhanced activity evident in the earlier part of the day in nor-mal subjects but not in those who had presented with acute coronary syndromes. Enhanced endothelial function during the earlier part of the day may normally counteract some of the potentially adverse consequences of diurnal variation of hemodynamic parameters and in thrombosis and fibrinolysis.…”

Section: Circadian Rhythms and Their Significancementioning

confidence: 99%

Circadian Variation of the Efficacy of Thrombolytic Therapy in Acute Myocardial Infarction—Isn’t the Time Ripe for Cardiovascular Chronotherapy?

et al. 2004

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This study was designed to assess the circadian variation of the efficacy of thrombolytic therapy (TT) in 163 patients with acute myocardial infarction. Statistical analysis of the results suggests the existence of circadian variation in the efficacy of thrombolytic therapy with marked early morning resistance and significantly better late daytime results. There is a strong relationship between the normal physiologic rhythms of biochemical, hemodynamic, and hematologic parameters, observed in patients with CAD and the circadian fluctuations of efficacy of TT. Obviously the efficacy of TT is influenced by more evident impact of chronorisk factors during the early morning hours.

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Section: Circadian Rhythms and Their Significancementioning

confidence: 99%