The effect of a biphasic desogestrel-containing oral contraceptive on carbohydrate metabolism and various hormonal parameters

Kühl, H.; Jung-Hoffmann, C.; Weber, J.; Boehm, B. O.

doi:10.1016/0010-7824(93)90109-k

Cited by 34 publications

(12 citation statements)

References 28 publications

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“…Smoking and smokeless tobacco use were not exclusionary. Women taking hormonal contraceptives were excluded from the present analysis, if they took part in a morning test session, in light of findings showing significantly elevated cortisol baseline levels and an absence of stress responses during the morning hours in this group relative to women not using hormonal contraceptives (Carr et al., ; Kuhl et al., ; Lovallo et al., ).…”

Section: Methodsmentioning

confidence: 99%

Early‐Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes

Lovallo

Cohoon

Sorocco

et al. 2019

Alcoholism Clin & Exp Res

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Background: Risk for alcoholism may be enhanced by exposure to early-life adversity (ELA) in persons with genetic vulnerabilities. We examined ELA in the presence of a common variant of the gene for the enzyme catechol-O-methyltransferase (COMT, Val158Met, rs4680) in relation to cortisol reactivity, the onset of early drinking, and experimentation with drugs.Methods: Saliva cortisol reactivity to speech and mental arithmetic stress was measured in 480 healthy young adults (23.5 years of age, 50% females) who experienced either 0, 1, or ≥ 2 forms of ELA during childhood and adolescence, provided information on use of alcohol and recreational drugs, and were genotyped for the Val158Met polymorphism.Results: ELA led to progressively smaller cortisol responses in the Met/Met and Val/Met allele groups but to progressively larger responses in Val homozygotes, F = 3.29, p = 0.011. ELA independently predicted earlier age at first drink, F = 14.2, p < 0.0001, with a larger effect in Met-allele carriers, F = 13.95, p < 0.00001, and a smaller effect in Val homozygotes, F = 4.14, p = 0.02. Similar effects were seen in recreational drug use. Cortisol reactivity was unrelated to drinking behavior or drug experimentation.Conclusions: ELA leads to blunted stress reactivity and, independently, contributes to potentially risky drinking and drug-use behaviors in persons carrying 1 or 2 copies of the COMT 158Met allele. The results reinforce the impact of early experience on the stress axis and on risky behaviors, and they point to the 158Met allele as conveying a vulnerability to the early environment.

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Section: Methodsmentioning

confidence: 99%

Early‐Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes

Lovallo

Cohoon

Sorocco

et al. 2019

Alcoholism Clin & Exp Res

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“…SHBG has been measured and reported in many studies on COCs and progestogen‐only preparations (15–53). We found some 35 published studies, where SHBG had been measured before the start and during COC use in women who had previously not been using contraceptive steroids for at least 1 month.…”

Section: Methodsmentioning

confidence: 99%

Can changes in sex hormone binding globulin predict the risk of venous thromboembolism with combined oral contraceptive pills?

Odlind

Milsom

Persson

et al. 2002

Acta Obstet Gynecol Scand

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“…Women using HC have consistently demonstrated blunted salivary or free cortisol response to a psychosocial stressor (Kirschbaum et al, 1999; Rohleder et al, 2003; Bouma et al, 2009), but shown heightened serum total cortisol levels both diurnally and in response to a psychosocial stressor or ACTH administration (Meulenberg et al, 1987; Meulenberg and Hofman 1990; Kuhl et al, 1993; Aden et al, 1998; Klose et al, 2007; Kumsta et al, 2007; Simunkova et al, 2008; Winkler and Sudik 2009). However, HC’s effect on diurnal salivary cortisol levels is less clear.…”

Section: Introductionmentioning

confidence: 99%

Hormonal contraceptive use diminishes salivary cortisol response to psychosocial stress and naltrexone in healthy women

Roche

King

Cohoon

et al. 2013

Pharmacology Biochemistry and Behavior

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The use of hormonal contraception (HC) may affect salivary cortisol levels at rest and in response to a pharmacological or stress challenge. Therefore, the current study used a secondary data analysis to investigate the effect of HC on salivary cortisol levels in response to the mu-opioid receptor antagonist naltrexone and a psychosocial stressor, and also across the diurnal curve. Two hundred and nine women (n = 72 using hormonal contraception; HC+) completed a two-session stress response study that consisted of a stress day, in which they were exposed to public speaking and mental arithmetic, and a rest day, in which unstimulated cortisol levels were measured to assess the diurnal rhythm. A subset of seventy women (n = 24 HC+) also completed a second study in which they were administered oral naltrexone (50 mg) or placebo in a randomized, placebo-controlled, double blind fashion. Women who were HC+ had a significantly reduced salivary cortisol response to both the psychosocial stressor (p < 0.001) and naltrexone (p < 0.05) compared to HC− women. Additionally, HC+ women had a significantly altered morning diurnal cortisol rhythm (p < 0.01), with a delayed peak and higher overall levels. The results of the current study confirm that HC attenuates salivary cortisol response to a psychosocial stressor and mu-opioid receptor antagonism, and also alters the morning diurnal cortisol curve.

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The effect of a biphasic desogestrel-containing oral contraceptive on carbohydrate metabolism and various hormonal parameters

Cited by 34 publications

References 28 publications

Early‐Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes

Early‐Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes

Can changes in sex hormone binding globulin predict the risk of venous thromboembolism with combined oral contraceptive pills?

Hormonal contraceptive use diminishes salivary cortisol response to psychosocial stress and naltrexone in healthy women

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