The effect of a high partial pressure of carbon dioxide environment on metabolism and immune functions of human peritoneal cells—Relevance to carbon dioxide pneumoperitoneum

Kopernik, Gideon; Avinoach, Eliezer; Grossman, Yoram; Lévy, Rachel; Yulzari, Robert; Rogachev, Boris; Douvdevani, Amos

doi:10.1016/s0002-9378(98)70016-x

Cited by 64 publications

(59 citation statements)

References 25 publications

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“…It has been demonstrated by in vitro studies that CO 2 pneumoperitoneum suppresses the metabolic response of leukocytes and lowers peritoneal macrophage activity, which also support our study results. [37,42,43] In a study researching the effect of CO 2 pneumoperitoneum on peritonitis in peritonitis-induced rats, similar to our study, 1 ml of E. coli suspension was administered within the peritoneal cavity and interleukin (IL)-6 and CRP values were measured to evaluate the inflammatory response. It was observed that these values were significantly low in the CO 2 pneumoperitoneum-induced group, and it was reported that CO 2 pneumoperitoneum reduces inflammatory response in the peritoneum in the case of sepsis, when compared to open surgery.…”

Section: Discussionmentioning

confidence: 92%

The effect of carbondioxide pneumoperitoneum on the severity peritonitis

Uzunköy¹,

Özardalı²,

Çelik³

et al. 2012

Ulus Travma Acil Cerrahi Derg

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AMAÇJeneralize peritonit olgularında hala, laparoskopik girişimlerin güvenilirliği ile ilgili kaygılar devam etmektedir. Bu deneysel çalışmada, deneysel peritonit oluşturulan sı-çanlarda karbondioksit (CO 2 ) pnömoperitonyumun enflematuvar cevap ve peritonit şiddeti üzerine etkilerinin araş-tırılması amaçlandı. GEREÇ VE YÖNTEMÇalışmada 21 Wistar albino cinsi sıçan kullanıldı. Sıçanlar üç gruba ayrıldı. Bunlar; kontrol (grup 1), bakteriyel peritonit oluşturulan grup (grup 2) ve peritonit + CO 2 pnömo-perituan oluşturulan grup (grup 3) idi. İkinci ve üçüncü gruptaki sıçanların periton içine Escherishia coli verilerek peritonit oluşturuldu. Üçüncü gruptaki sıçanlarda CO 2 insuflasyonu ile pnömoperitonyum oluşturuldu. Sıçanlar 24 saat sonra öldürüldü, kan ve karın duvarından periton ör-neği alındı. Tüm gruplarda peritonit şiddet skoru, C-reaktif protein düzeyi ve kanda beyaz küre sayısı değerlendirildi. BULGULARPeritonit şiddet skoru, C-reaktif protein düzeyi ve kan beyaz küre sayısı, ikinci ve üçüncü gruplarda, birinci gruba göre anlamlı düzeyde yüksek bulundu (p<0,05). Üçüncü grupta değerler, ikinci gruptan anlamlı düzeyde düşük bulundu (p<0,05). SONUÇÇalışmamızın sonuçları, CO 2 pnömoperitonyumun Escherishia coli ile peritonit ve sepsis oluşturulan sıçanlarda peritonit şiddetini ve sistemik enflematuvar yanıtı azalttığı-nı göstermiştir.

show abstract

Section: Discussionmentioning

confidence: 92%

The effect of carbondioxide pneumoperitoneum on the severity peritonitis

Uzunköy¹,

Özardalı²,

Çelik³

et al. 2012

Ulus Travma Acil Cerrahi Derg

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“…This technique has some advantages over existing models. Intraperitoneal fluid infusion is likely to be absorbed and therefore may interfere with the pathophysiological response to IAH [10], while the use of CO 2 insufflation may represent an additional physiologic variable [8]. Furthermore, CO 2 may be absorbed and the gas volume can be compressed, whereas saline and cotton dressings cannot.…”

Section: Discussionmentioning

confidence: 99%

“…Although experimental models of IAH were developed using CO 2 insufflation, it is difficult to maintain high IAP levels for prolonged periods [8]. To address this issue, some authors have suggested the use of peritoneal saline infusion [9], rather than CO 2 insufflation to generate a lengthy IAH model [10].…”

mentioning

confidence: 99%

Early impact of abdominal compartment syndrome on liver, kidney and lung damage in a rodent model

Lima¹,

Silva²,

Capelozzi³

et al. 2017

Anaesthesiol Intensive Ther

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Background: Abdominal compartment syndrome (ACS) sometimes occurs in critically ill patients following damage control surgery. The purpose of the present study was to develop a model of ACS and to evaluate its pathologic impact on liver, kidney, and lung morphology. Methods: Twenty Wistar rats (mass 300-350 g) were randomly divided into four groups: 1) intra-abdominal hypertension (IAH): a laparotomy was performed and the abdomen packed with cotton until an intra-abdominal pressure (IAP) of 15 mm Hg was reached; 2) hypovolemia (HYPO): blood was withdrawn until a mean arterial pressure ~60 mm Hg was reached; 3) IAH + HYPO (to resemble clinical ACS); and 4) sham surgery. After 3 hours of protective mechanical ventilation, the animals were euthanized and the liver, kidney and lungs removed to examine the degree of tissue damage. Results: IAH resulted in the following: oedema and neutrophil infiltration in the kidney; necrosis, congestion, and microsteatosis in the liver; and alveolar collapse, haemorrhage, interstitial oedema, and neutrophil infiltration in the lungs. Furthermore, IAH was associated with greater cell apoptosis in the kidney, liver and lungs compared to sham surgery. HYPO led to oedema and neutrophil infiltration in the kidney. The combination of IAH and HYPO resulted in all the aforementioned changes in lung, kidney and liver tissue, as well as exacerbation of the inflammatory process in the kidney and liver and kidney cell necrosis and apoptosis. Conclusions: Intra-abdominal hypertension by itself is associated with kidney, liver and lung damage; when combined with hypovolemia, it leads to further impairment and organ damage.

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“…This could be attributable to the use of CO2 or it might be attributable to the desiccation of the peritoneal surface by cold insufflation of the gas. [26][27][28][29] Carbon Dioxide (CO2)…”

Section: Peritoneum;mentioning

confidence: 99%

Abdominal Effects Of Laparoscopic Surgery

Tolan¹

2017

Laparosc Endosc Surg Sci

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Pneumoperitoneum (PNP) is very commonly performed in surgical practice due to the extensive use of laparoscopic surgery. In minimally invasive surgery, there is an effort to convert all eligible surgical procedures to a laparoscopic technique, as it has fewer systemic and local surgical effects on the patient. During PNP, intraperitoneal pressure (IPP) is increased to well above normal intra-abdominal pressure in order to create an opening for visualization of the abdominal contents. The duration of these procedures can be prolonged as a result of the difficulties and complexities of these techniques. IPP has side effects on the physiology of patients, as is seen in abdominal compartment syndrome.

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The effect of a high partial pressure of carbon dioxide environment on metabolism and immune functions of human peritoneal cells—Relevance to carbon dioxide pneumoperitoneum

Cited by 64 publications

References 25 publications

The effect of carbondioxide pneumoperitoneum on the severity peritonitis

The effect of carbondioxide pneumoperitoneum on the severity peritonitis

Early impact of abdominal compartment syndrome on liver, kidney and lung damage in a rodent model

Abdominal Effects Of Laparoscopic Surgery

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