The Effect of a Multi-ingredient Supplement on Resistance Training–induced Adaptations

Wageh, Mai; Fortino, Stephen A.; McGlory, Chris; Kumbhare, Dinesh; Phillips, Stuart M.; Parise, Gianni

doi:10.1249/mss.0000000000002641

Cited by 6 publications

(8 citation statements)

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“…Our findings demonstrate that the myofiber size of untrained males is modulated in part by the responsivity of nAR content to RET, which extends previous reports of AR influencing baseline CSA 13,24,25 . It is worth noting that our previously published study found no effect of supplement on vastus lateralis CSA, but found an effect on biceps and whole‐body lean mass 30 . Our present findings emphasize the role of nAR content in male RET‐induced adaptation since total AR content was unrelated to hypertrophy.…”

Section: Discussionsupporting

confidence: 86%

“…Twenty‐six healthy, young males ( n = 13; 21.8 ± 0.6 years) and females ( n = 13; 22.1 ± 0.6 years) were recruited. All participants were recreationally active and did not participate in any structured exercise for a year prior to enrolling in this trial, which was part of a larger investigation examining the effects of a multi‐ingredient supplement on the resistance training adaptive response 30 . For the purposes of this study, the placebo and supplement groups were combined to understand the acute and chronic exercise‐induced changes on AR biology in males and females.…”

Section: Methodsmentioning

confidence: 99%

“…The training program consisted of four supervised sessions per week of whole‐body linear resistance exercise, for 10 weeks. Each resistance training session included a variety of upper and lower body exercises consisting of 3–5 sets and 8–12 reps at 80% of the subjects' 1 repetition maximum (1RM) 30 . Maximal strength testing was assessed prior to the current study using 1RM calculated as the maximum amount of mass (kg) pushed for one repetition of leg press, bench press, or latissimus dorsi pull‐down.…”

Section: Methodsmentioning

confidence: 99%

“…The study design has been previously described in detail. 23,30 Briefly, participants reported to the laboratory for a baseline skeletal muscle biopsy from the vastus lateralis and then performed an eccentric damaging protocol. Next, another skeletal muscle biopsy was obtained 48 h after the damaging stimulus.…”

Section: Protocolmentioning

confidence: 99%

“…Eccentric damage was completed using an isokinetic unilateral dynamometer (Biodex-System 3, Biodex Medical Systems) as previously described. 23,30 Briefly, subjects performed 30 sets of 10 maximal muscle-lengthening contractions of the knee extensors with 60 s of rest between sets for a total of 300 lengthening contractions on the leg of interest. This protocol is proven, by our group and others, 23,31,32,33,34 to induce acute skeletal muscle damage.…”

Section: Eccentric Damagementioning

confidence: 99%

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Nuclear‐localized androgen receptor content following resistance exercise training is associated with hypertrophy in males but not females

Hatt,

Kamal,

Mikhail

et al. 2024

The FASEB Journal

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Androgen receptor (AR) content has been implicated in the differential response between high and low responders following resistance exercise training (RET). However, the influence of AR expression on acute skeletal muscle damage and whether it may influence the adaptive response to RET in females is poorly understood. Thus, the purpose of this exploratory examination was to 1) investigate changes in AR content during skeletal muscle repair and 2) characterize AR‐mediated sex‐based differences following RET. A skeletal muscle biopsy from the vastus lateralis was obtained from 26 healthy young men (n = 13) and women (n = 13) at baseline and following 300 eccentric kicks. Subsequently, participants performed 10 weeks of full‐body RET and a final muscle biopsy was collected. In the untrained state, AR mRNA expression was associated with paired box protein‐7 (PAX7) mRNA in males. For the first time in human skeletal muscle, we quantified AR content in the myofiber and localized to the nucleus where AR has been shown to trigger cellular outcomes related to growth. Upon eccentric damage, nuclear‐associated AR (nAR) content increased (p < .05) in males and not females. Males with the greatest increase in cross‐sectional area (CSA) post‐RET had more (p < .05) nAR content than females with the greatest gain CSA. Collectively, skeletal muscle damage and RET increased AR protein, and both gene and hypertrophy measures revealed sex differences in relation to AR. These findings suggest that AR content but more importantly, nuclear localization, is a factor that differentiates RET‐induced hypertrophy between males and females.

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Section: Discussionsupporting

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Protocolmentioning

confidence: 99%

Section: Eccentric Damagementioning

confidence: 99%

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Nuclear‐localized androgen receptor content following resistance exercise training is associated with hypertrophy in males but not females

Hatt,

Kamal,

Mikhail

et al. 2024

The FASEB Journal

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Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis

Bischof,

Moitzi,

Stafilidis

et al. 2024

Sports Med

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Introduction Over the past decade, collagen peptide (CP) supplements have received considerable attention in sports nutrition research. These supplements have shown promising results in improving personal health, enhancing athletic performance, and preventing injuries in some but not all studies. Objective A systematic review and meta-analysis of randomized controlled trials (RCTs) has been conducted to investigate the effects of long-term daily collagen peptide (CP) supplementation on strength, musculotendinous adaptation, functional recovery, and body composition in healthy adults, both with and without concurrent exercise interventions over several weeks. Methods The PRISMA with PERSiST guidelines were followed for this systematic literature review, which was conducted in December 2023 using PubMed, Scopus, CINAHL, and SPORTDiscus databases. Eligible studies included healthy, normal to overweight adults over 17 years of age who engaged in exercise and daily collagen peptide (CP) supplementation for a minimum of 8 weeks (except one 3-week trial only included for maximal strength). Studies examining recovery-related outcomes were also eligible if they included a 1-week supplementation period without exercise. Methodological study quality was assessed using the PEDro scale. A random-effects model with standardized mean differences (SMD) of change scores was chosen to calculate overall effect sizes. Results Nineteen studies comprising 768 participants were included in both the systematic review and meta-analysis. Results indicate statistically significant effects in favor of long-term CP intake regarding fat-free mass (FFM) (SMD 0.48, p < 0.01), tendon morphology (SMD 0.67, p < 0.01), muscle architecture (SMD 0.39, p < 0.01), maximal strength (SMD 0.19, p < 0.01), and 48 h recovery in reactive strength following exercise-induced muscle damage (SMD 0.43, p = 0.045). The GRADE approach revealed a moderate certainty of evidence for body composition, a very low certainty for tendon morphology and mechanical properties, and a low certainty for the remaining. Conclusion This systematic review and meta-analysis represents the first comprehensive investigation into the effects of long-term CP supplementation combined with regular physical training on various aspects of musculoskeletal health in adults. The findings indicate significant, though of low to moderate certainty, evidence of improvements in fat-free mass (FFM), tendon morphology, muscle mass, maximal strength, and recovery in reactive strength following exercise-induced muscle damage. However, further research is required to fully understand the mechanisms underlying these effects, particularly regarding tendon mechanical properties and short-term adaptations to collagen peptide (CP) intake without exercise, as observed in recovery outcomes. Overall, CP supplementation appears promising as a beneficial adjunct to physical training for enhancing musculoskeletal performance in adults. Open Science Framework (Registration DOI: https://doi.org/10.17605/OSF.IO/WCF4Y).

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Scientific meeting report: International Biochemistry of Exercise 2022

Vainshtein¹,

Slavin

Cheng

et al. 2022

Journal of Applied Physiology

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Exercise is one of the only non-pharmacologic remedies known to counteract genetic and chronic diseases by enhancing health and improving life span. Although the many benefits of regular physical activity have been recognized for some time, the intricate and complex signalling system triggered at the onset of exercise have only recently begun to be uncovered. Exercising muscles initiate a coordinated, multisystemic, metabolic rewiring which is communicated to distant organs by various molecular mediators, including extracellular vesicles such as exosomes. The field of exercise research has been expanding beyond the musculoskeletal system, with interest from industry to provide realistic models and exercise mimetics that evoke a whole-body rejuvenation response. This year's 18th International Biochemistry of Exercise conference took place in Toronto, Canada, from May 25th to May 28th, 2022, with more than 400 attendees. Here we provide an overview of the most cutting-edge exercise-related research presented by 66 speakers, focusing on new developments in topics ranging from molecular and cellular mechanisms of exercise adaptations, diabetes, and aging. We also provide descriptions on how manipulation of these signaling pathways provide therapeutic avenues for improving human health and quality of life.

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The Effect of a Multi-ingredient Supplement on Resistance Training–induced Adaptations

Abstract: Supplemental digital content is available in the text.

Cited by 6 publications

References 48 publications

Nuclear‐localized androgen receptor content following resistance exercise training is associated with hypertrophy in males but not females

Nuclear‐localized androgen receptor content following resistance exercise training is associated with hypertrophy in males but not females

Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis

Scientific meeting report: International Biochemistry of Exercise 2022

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