The effect of a selective 5‐HT₂ antagonist, ketanserin, on the pulmonary responses to Escherichia coli endotoxin

5‐Hydroxytryptamine‐induced bronchoconstriction in the guinea‐pig: effect of 5‐HT2 receptor activation on acetylcholine release

“…In contrast, ketanserin inhibited it. Similar inhibition by ketanserin of the bronchoconstrictor responses to the 5-HT was previously reported in guinea-pig isolated perfused lung by Selig et al (1989) and in cats by Ball et al (1983). It is well established that the 5-HT receptors mediating tracheal smooth muscle contraction are of the 5-HT2 subtype (Cohen et al, 1985;Lemoine & Kauman, 1986).…”

Feline pulmonary hypertension: are we overlooking an important comorbidity?

“…In other models of PAH, the Escherichia coli endotoxin was infused into cats, to induce PAH, and, with this, the modification of PAH in the presence of various vasoactive compounds. [69][70][71][72] Sleep apnea has been described in the cat; however, as yet, PH has not been described in association with sleep apnea in cats. 73 Furthermore, no studies have assessed the effect of chronic exposure to high altitude on the feline pulmonary vasculature.…”

Ketanserin

“…This vasoconstrictor response can be reversed by ketanserin (250,278). Likewise, in anesthetized dogs and cats the increase in vascular resistance of femoral and pulmonary arteries in response to serotonin is antagonized by ketanserin, whereas the dilatation of small vessels is not (7,10,23,173). A study in anesthetized pigs also showed that ketanserin blocks the reduction by serotonin of total carotid blood flow and enhances serotonin-induced arteriolar vasodilatation (283).…”

“…The no-effect oral doses were 10 mg/100 g food for rats, corresponding to approximately I0 mg/kg body weight, 10.0 mg/kg body weight for dogs. The no-effect intravenous doses were 0.63 and 1.25 mg/kg body weight given as a daily bolus injection in rats and in dogs for 2-4 weeks.…”

“…In rats the effective dose for the acute lowering of blood pressure is correlated with its affinity to a,-adrenergic receptors, indicating that in this species the acute hypotensive effect of ketanserin is related primarily to its a, -adrenergic 134. ) serotpnin , (~/ k g , ) 10 …”