The Effect of a Single Remote Course Versus Weekly Courses of Antenatal Corticosteroids on Functional Residual Capacity in Preterm Infants: A Randomized Trial

McEvoy, Cindy T.; Bowling, S; Williamson, Kathleen M.; Lozano, David; Tolaymat, Lama; Izquierdo, Luis A.; Mäher, James; Helfgott, Andrew

doi:10.1542/peds.110.2.280

Cited by 65 publications

(61 citation statements)

References 22 publications

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“…83 In contrast, no difference in FRC N2 was observed between single and multiple doses of prenatal steroids. 84 In the context of hyaline membrane disease, a low FRC implies a relatively collapsed lung, which is consistent with the retrospective observation that infants with low FRCs have high ventilatory and surfactant needs. 82 Increases in FRC pre-and post surfactant treatment are physiologically and clinically highly relevant.…”

Section: The Extent To Which Functional Findings Can Be Related To Pasupporting

confidence: 84%

“…FRC N2 was used as an outcome parameter to assess the impact of prenatal steroid treatment. 83,84 Preterm babies ventilated for RDS who had not received prenatal steroids had significantly lower FRC N2 in the first 48 hr of extrauterine life compared with matched controls. 83 In contrast, no difference in FRC N2 was observed between single and multiple doses of prenatal steroids.…”

Section: The Extent To Which Functional Findings Can Be Related To Pamentioning

confidence: 98%

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Lung Function Tests in Neonates and Infants with Chronic Lung Disease of Infancy: Functional Residual Capacity

Hülskamp¹,

Pillow²,

Dinger³

et al. 2005

Pediatric Pulmonology

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Summary. This is the second paper in a review series that will summarize available data and discuss the potential role of lung function testing in infants and young children with acute neonatal respiratory disorders and chronic lung disease of infancy. The current paper addresses the expansive subject of measurements of lung volume using plethysmography and gas dilution/ washout techniques. Following orientation of the reader to the subject area, we focus our comments on areas of inquiry proposed in the introductory paper to this series. The quality of the published literature is reviewed critically, and recommendations are provided to guide future investigation in this field. Measurements of lung volume are important both for assessing growth and development of lungs in health and disease, and for interpreting volume-dependent lung function parameters such as respiratory compliance, resistance, forced expiratory flows, and indices of gas-mixing efficiency. Acute neonatal lung disease is characterized by severely reduced functional residual capacity (FRC), with treatments aimed at securing optimal lung recruitment. While FRC may remain reduced in established chronic lung disease of infancy, more commonly it becomes normalized or even elevated due to hyperinflation, with or without gas-trapping, secondary to airway obstruction. Ideally, accurate and reliable bedside measurements of FRC would be feasible from birth, throughout all phases of postnatal care (including assisted ventilation), and during subsequent long-term follow-up. Although lung volume measurements in extremely preterm infants were described in a research environment, resolution of several issues is required before such investigations can be translated into routine clinical monitoring. Pediatr

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Section: The Extent To Which Functional Findings Can Be Related To Pasupporting

confidence: 84%

Section: The Extent To Which Functional Findings Can Be Related To Pamentioning

confidence: 98%

Lung Function Tests in Neonates and Infants with Chronic Lung Disease of Infancy: Functional Residual Capacity

Hülskamp¹,

Pillow²,

Dinger³

et al. 2005

Pediatric Pulmonology

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“…The review of repeat antenatal corticosteroid course(s) 661 for the prevention of neonatal respiratory disease included three RCTs (n = 551); [662][663][664] no additional trials were found. Further details of the review can be found in Appendix 6, Table 139.…”

Section: Repeat Corticosteroid Course(s)mentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

2010

Clinical Governance: An International Journal

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How to obtain copies of this and other HTA programme reports An electronic version of this publication, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable CD-ROM is also available (see below).Printed copies of HTA monographs cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our Despatch Agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in t...

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“…Crowther et al ont réalisé, en 2007, une méta-analyse qui regroupait cinq études contrôlées randomisées avec placebo [46][47][48][49][50]. Ces cinq travaux impliquaient 2028 femmes.…”

Section: Effets De La Répétition Des Cures De Corticoïdes Chez L'hommunclassified

Répétition des cures de corticoïdes chez les femmes à risque d’accouchement prématuré : un consensus difficile

Guilherme

Renaud

Dommergues

et al. 2009

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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The Effect of a Single Remote Course Versus Weekly Courses of Antenatal Corticosteroids on Functional Residual Capacity in Preterm Infants: A Randomized Trial

Abstract: Our results demonstrate that weekly repetitive courses of AS do not significantly increase FRC or respiratory compliance in preterm infants when compared with a single remote course of steroids given at a mean gestational age of 29 weeks.

Cited by 65 publications

References 22 publications

Lung Function Tests in Neonates and Infants with Chronic Lung Disease of Infancy: Functional Residual Capacity

Lung Function Tests in Neonates and Infants with Chronic Lung Disease of Infancy: Functional Residual Capacity

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Répétition des cures de corticoïdes chez les femmes à risque d’accouchement prématuré : un consensus difficile

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