The Effect of a Specific Chicken Based Renal Diet as Monotherapy on Clinical, Biochemical, Urinary and Serum Oxidative Stress Parameters in Cats With CKD Stage 1 and 2

Žel, Martina Krofič; Svete, Alenka Nemec; Jakovac-Strajn, Breda; Vrtač, Katarina Pavšič; Vovk, Tomaž; Kejžar, Nataša; Pavlin, Darja

doi:10.26873/svr-1515-2023

Cited by 2 publications

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“…In this retrospective study, data from hematological, biochemical, and urine analyses of client-owned cats examined from 2010 to 2018 at the Clinic for Small Animals of the Veterinary Faculty in Ljubljana, Slovenia, were analyzed. The cats were included in previously published studies involving research on antioxidant parameters in cats with IRIS stages 1–4 CKD [ 24 ] and the effect of diet on the progression of CKD [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Hemogram-Derived Inflammatory Markers in Cats with Chronic Kidney Disease

Krofič Žel,

Nemec Svete,

Tozon

et al. 2024

Animals

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Chronic kidney disease (CKD) is characterized by chronic inflammation, which mediates the progressive replacement of functional nephrons by fibrotic tissue. Hemogram-derived inflammatory markers are known to serve as markers of pathological conditions; however, their diagnostic value in feline CKD is still unknown. The aim of this retrospective study was to investigate selected hemogram-derived inflammatory markers (neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR) and the systemic immune-inflammatory index (SII)) in cats at different clinical stages of CKD. Eighty-eight client-owned cats with CKD and thirty-two healthy control cats were included. Cats with CKD were divided into two groups: early CKD (IRIS stage 1 and 2; 62 cats) and progressed CKD (IRIS stage 3 and 4; 26 cats). The values of inflammatory markers were compared between the two CKD groups and the control group. All investigated hemogram-derived inflammatory markers were significantly (p < 0.05) greater in cats with advanced CKD than in those in the other two groups. Additionally, we demonstrated a statistically significant weak to moderate correlation between serum urea, creatinine, selected hematologic and urinary parameters, and the investigated inflammatory markers in cats with CKD. Chronic inflammation can be easily and inexpensively assessed with hemogram-derived markers.

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Section: Methodsmentioning

confidence: 99%

Hemogram-Derived Inflammatory Markers in Cats with Chronic Kidney Disease

Krofič Žel,

Nemec Svete,

Tozon

et al. 2024

Animals

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Supplementation of vitamin E as an addition to a commercial renal diet does not prolong survival of cats with chronic kidney disease

Krofič Žel,

Tavčar Kalcher,

Vovk

et al. 2024

BMC Vet Res

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Background The aim of this double-blind, placebo-controlled study was to investigate the effect of vitamin E supplementation as an addition to a commercial renal diet on survival time of cats with different stages of chronic kidney disease (CKD). In addition, we were interested whether vitamin E supplementation affects selected oxidative stress and clinical parameters. Thirty-four cats with CKD and 38 healthy cats were included in the study. Cats with CKD were classified according to the IRIS Guidelines; seven in IRIS stage 1, 15 in IRIS stage 2, five in IRIS stage 3 and seven in IRIS stage 4. Cats with CKD were treated according to IRIS Guidelines. Cats with CKD were randomly assigned to receive vitamin E (100 IU/cat/day) or placebo (mineral oil) for 24 weeks in addition to standard therapy. Plasma malondialdehyde (MDA) and protein carbonyl (PC) concentrations, DNA damage of peripheral lymphocytes and plasma vitamin E concentrations were measured at baseline and four, eight, 16 and 24 weeks thereafter. Routine laboratory analyses and assessment of clinical signs were performed at each visit. Results Vitamin E supplementation had no effect on the survival time and did not reduce the severity of clinical signs. Before vitamin E supplementation, no significant differences in vitamin E, MDA and PC concentrations were found between healthy and CKD cats. However, plasma MDA concentration was statistically significantly higher (p = 0.043) in cats with early CKD (IRIS stages 1 and 2) than in cats with advanced CKD (IRIS stages 3 and 4). Additionally, DNA damage was statistically significantly higher in healthy cats (p ≤ 0.001) than in CKD cats. Plasma vitamin E concentrations increased statistically significantly in the vitamin E group compared to the placebo group four (p = 0.013) and eight (p = 0.017) weeks after the start of vitamin E supplementation. During the study and after 24 weeks of vitamin E supplementation, plasma MDA and PC concentrations and DNA damage remained similar to pre-supplementation levels in both the placebo and vitamin E groups. Conclusions Vitamin E supplementation as an addition to standard therapy does not prolong survival in feline CKD.

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The Effect of a Specific Chicken Based Renal Diet as Monotherapy on Clinical, Biochemical, Urinary and Serum Oxidative Stress Parameters in Cats With CKD Stage 1 and 2

Cited by 2 publications

References 0 publications

Hemogram-Derived Inflammatory Markers in Cats with Chronic Kidney Disease

Hemogram-Derived Inflammatory Markers in Cats with Chronic Kidney Disease

Supplementation of vitamin E as an addition to a commercial renal diet does not prolong survival of cats with chronic kidney disease

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