The effect of adding an organic solvent to povidone aqueous solution on the size of MCC granules obtained by wet granulation

Abstract

Most of the developed new pharmaceutical substances are insoluble in water, which makes it difficult to create solid dosage forms. This makes researchers use solubilization approaches for poorly soluble molecules. In our study, the applicability of ethyl alcohol as a cosolvent in the technology of wet granulation of tablets was analyzed.