The Effect of Aging on Tubal Function and Ectopic Pregnancy

Yeko, Timothy R.; Handler, Arden

doi:10.1055/s-2007-1019412

Cited by 14 publications

(7 citation statements)

References 35 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Age-related changes in tubal function may delay ovum transport and result in tubal implantation. However, these hypotheses remain to be tested (42).…”

Section: Agementioning

confidence: 98%

Risk Factors for Ectopic Pregnancy: A Comprehensive Analysis Based on a Large Case-Control, Population-based Study in France

Bouyer

Coste²,

Shojaei³

et al. 2003

American Journal of Epidemiology

431

273

View full text Add to dashboard Cite

This case-control study was associated with a regional register of ectopic pregnancy between 1993 and 2000 in France. It included 803 cases of ectopic pregnancy and 1,683 deliveries and was powerful enough to investigate all ectopic pregnancy risk factors. The main risk factors were infectious history (adjusted attributable risk = 0.33; adjusted odds ratio for previous pelvic infectious disease = 3.4, 95% percent confidence interval (CI): 2.4, 5.0) and smoking (adjusted attributable risk = 0.35; adjusted odds ratio = 3.9, 95% CI: 2.6, 5.9 for >20 cigarettes/day vs. women who had never smoked). The other risk factors were age (associated per se with a risk of ectopic pregnancy), prior spontaneous abortions, history of infertility, and previous use of an intrauterine device. Prior medical induced abortion was associated with a risk of ectopic pregnancy (adjusted odds ratio = 2.8, 95% CI: 1.1, 7.2); no such association was observed for surgical abortion (adjusted odds ratio = 1.1, 95% CI: 0.8, 1.6). The total attributable risk of all the factors investigated was 0.76. As close associations were found between ectopic pregnancy and infertility and between ectopic pregnancy and spontaneous abortion, further research into ectopic pregnancy should focus on risk factors common to these conditions. In terms of public health, increasing awareness of the effects of smoking may be useful for ectopic pregnancy prevention.

show abstract

“…Age-related changes in tubal function may delay ovum transport and result in tubal implantation. However, these hypotheses remain to be tested (42).…”

Section: Agementioning

confidence: 98%

Risk Factors for Ectopic Pregnancy: A Comprehensive Analysis Based on a Large Case-Control, Population-based Study in France

Bouyer

Coste²,

Shojaei³

et al. 2003

American Journal of Epidemiology

431

273

View full text Add to dashboard Cite

show abstract

“…The explanation for this observation is unknown, however age is theorized to affect tubal function, including delay of oocyte transport [36, 37]. …”

Section: Reviewmentioning

confidence: 99%

“…Age has been shown to be a risk factor for EP, with the highest incidence over the age of 35 in both spontaneous pregnancies and those conceived after assisted reproductive technologies [ 7 , 36 ]. The explanation for this observation is unknown, however age is theorized to affect tubal function, including delay of oocyte transport [ 36 , 37 ].…”

Section: Reviewmentioning

confidence: 99%

Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review

Panelli

Phillips

Brady

2015

Fertil Res and Pract

207

251

View full text Add to dashboard Cite

BackgroundEctopic pregnancy is a potentially life-threatening condition occurring in 1-2 % of all pregnancies. The most common ectopic implantation site is the fallopian tube, though 10 % of ectopic pregnancies implant in the cervix, ovary, myometrium, interstitial portion of the fallopian tube, abdominal cavity or within a cesarean section scar.FindingsDiagnosis involves a combination of clinical symptoms, serology, and ultrasound. Medical management is a safe and effective option in most clinically stable patients. Patients who have failed medical management, are ineligible, or present with ruptured ectopic pregnancy or heterotopic pregnancy are most often managed with excision by laparoscopy or, less commonly, laparotomy. Management of nontubal ectopic pregnancies may involve medical or surgical treatment, or a combination, as dictated by ectopic pregnancy location and the patient's clinical stability. Following tubal ectopic pregnancy, the rate of subsequent intrauterine pregnancy is high and independent of treatment modality.ConclusionThis review describes the incidence, risk factors, diagnosis, and management of tubal and non-tubal ectopic and heterotopic pregnancies, and reviews the existing data regarding recurrence and future fertility.

show abstract

“…12 It was hypothesized that age related changes in tubal function may delay ovum transport and cause tubal implantation. 13 Three women (8.8%) had prior spontaneous abortions in our study. The association between prior spontaneous abortion and risk of EP has been variably reported.…”

Section: Resultsmentioning

confidence: 60%

Analysis of risk factors and treatment outcome following methotrexate therapy in ectopic pregnancy

Amudha

Shenbagam

Raji

2022

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Ectopic pregnancy is a significant cause of morbidity and mortality in first trimester of pregnancy. Awareness regarding risk factors for ectopic pregnancy aids in early diagnosis and timely medical intervention before tubal rupture occurs. This study was undertaken to analyze the risk factors for ectopic pregnancy and to study the treatment outcome following methotrexate therapy.Methods: In this prospective study, 34 women with unruptured ectopic pregnancy selected for medical therapy were enrolled women with ectopic pregnancy who were hemodynamically stable with initial beta-human chorionic gonadotropin (β hCG) values of <5000 mIU/l, ectopic gestation mass size <5 cm and with no contraindication for methotrexate use were included in the study. Risk factors for ectopic pregnancy were studied and treatment outcome following single dose or 2 dose methotrexate regimen were analyzed.Results: The mean age of the study group was 26.88±4.5 years. Highest incidence of ectopic pregnancy was noted in 26-30 years and in second gravidas. Successful treatment outcome was observed in 61.8% with single dose methotrexate (MTX) and in 23.5% with 2 doses. Overall success rate of MTX therapy was 85.3%. Surgical intervention was instituted in 14.7% when pretreatment β hCG levels were <1500 mIU/ml. Single dose MTX was successful in 91.7% and with 2 doses it was 100%. None developed any major side effects to methotrexate therapy.Conclusions: MTX therapy is safe and effective in carefully selected women with ectopic pregnancy. Success rate of MTX therapy was 85.3%. MTX was most effective when pretreatment β hCG levels were less than 1500 mIU/ml.

show abstract

The Effect of Aging on Tubal Function and Ectopic Pregnancy

Cited by 14 publications

References 35 publications

Risk Factors for Ectopic Pregnancy: A Comprehensive Analysis Based on a Large Case-Control, Population-based Study in France

Risk Factors for Ectopic Pregnancy: A Comprehensive Analysis Based on a Large Case-Control, Population-based Study in France

Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review

Analysis of risk factors and treatment outcome following methotrexate therapy in ectopic pregnancy

Contact Info

Product

Resources

About