The Effect of AlloDerm Envelopes on Periprosthetic Capsule Formation with and without Radiation

Komorowska-Timek, Ewa; Oberg, Kerby C.; Timek, Tomasz A.; Gridley, Daila S.; Miles, D

doi:10.1097/prs.0b013e318199eef3

Cited by 103 publications

(50 citation statements)

References 43 publications

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“…14 Furthermore, there are reports on reduced capsule formation in patients with an Alloderm â envelope and following radiation. 15 Alloderm â may slow the progression of capsule formation, fibrosis, and contraction via a decreased radiation-related inflammation.…”

Section: Discussionmentioning

confidence: 99%

Prepectoral implant placement and complete coverage with porcine acellular dermal matrix: A new technique for direct-to-implant breast reconstruction after nipple-sparing mastectomy

Reitsamer

Peintinger

2015

Journal of Plastic, Reconstructive & Aesthetic Surgery

193

158

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Section: Discussionmentioning

confidence: 99%

Prepectoral implant placement and complete coverage with porcine acellular dermal matrix: A new technique for direct-to-implant breast reconstruction after nipple-sparing mastectomy

Reitsamer

Peintinger

2015

Journal of Plastic, Reconstructive & Aesthetic Surgery

193

158

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“…27 Komorowska-Timek et al evaluated the effect of radiation on human acellular dermal matrix in rat implant capsules. 28 They found invasion of inflammatory infiltrates into nonirradiated human acellular dermal matrix at 3 weeks and a steady decrease in mesh thickness over time. Within irradiated human acellular dermal matrix, cellular invasion was diminished.…”

Section: Animal Studies Of Acellular Dermal Matrixmentioning

confidence: 98%

Acellular Dermal Matrix in Irradiated Tissue Expander/Implant–Based Breast Reconstruction

Clemens

Kronowitz

2012

Plastic and Reconstructive Surgery

106

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“…In contrast, ADM-assisted reconstructions have consistently been associated with CC rates of <5%, albeit a shorter follow-up period of 0.6-2.4-year (9-15) is reported. Mechanistic studies in animal models as well as human histopathologic studies suggest a reduction or delay in capsule formation in the presence of ADM as a possible explanation for the reduced occurrence of CC (5,(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Capsular contracture in implant based breast reconstruction—the effect of porcine acellular dermal matrix

Lardi

Ho-Asjoe

Junge³

et al. 2017

Gland Surg.

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Background: Irradiation of implant-based breast reconstructions (BR) is known to increase capsular contracture (CC) rates on average by 4-fold over non-irradiated reconstructions. The use of acellular dermal matrix (ADM) has been associated with lower CC rates in non-irradiated reconstructions (0-3%).Experimental and clinical studies suggest that ADM may also reduce CC rates in irradiated breasts. The aim of this study was to evaluate CC rates in non-irradiated and irradiated one-and two-stage BRs performed with the assistance of porcine ADM (PADM).Methods: A single centre, retrospective, cohort study was designed from December 2008 to October 2012.A total of 200 immediate implant-based BRs were performed using PADM for inferior pole reinforcement.We included non-irradiated BR with a minimum follow up of 6 month from primary surgery (one stage) or from explantation of expander and implantation of the definitive implant (two stage). Of the postoperatively irradiated BR we included patients with 1 year or more follow up time from termination of radiotherapy.CC was graded using the conventional Spear-Baker classification and modified version for irradiated BR.According to the literature Grade III and IV CC were defined as clinically significant CC. Results: Of 200 BRs with PADM, 122 were included in this study (84 non-irradiated and 38 irradiated).Sixty-five BR were one stage and 57 were two stage BR. Grade III/IV CC was remarkable low in nonirradiated (6%) and irradiated BR (13%). There was a non-significant trend to increased Grade III and IV CC in irradiated BR vs. non-irradiated BR (13% vs. 6%, P=0.216). In this study follow up time (P<0.001) and the stage of ADM reconstruction (two vs. one stage, P=0.022) were significant risk factors for occurrence of grade III/IV CC on univariate analysis and remained significant for the follow up time (P=0.013) and remarkable for the stages (P=0.093) in multivariate analysis. Conclusions:Our data support the current clinical evidence that ADM use in implant-based BR is associated with a reduced risk of CC when compared to the standard submuscular techniques in literature.The reduced risk is maintained in the setting of radiotherapy. Two stage procedures in our study population showed increased grade III/IV CC compared to one stage procedures with or without exposure to radiation.

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The Effect of AlloDerm Envelopes on Periprosthetic Capsule Formation with and without Radiation

Abstract: AlloDerm decreases radiation-related inflammation and delays or diminishes pseudoepithelium formation and thus may slow progression of capsular formation, fibrosis, and contraction.

Cited by 103 publications

References 43 publications

Prepectoral implant placement and complete coverage with porcine acellular dermal matrix: A new technique for direct-to-implant breast reconstruction after nipple-sparing mastectomy

Prepectoral implant placement and complete coverage with porcine acellular dermal matrix: A new technique for direct-to-implant breast reconstruction after nipple-sparing mastectomy

Acellular Dermal Matrix in Irradiated Tissue Expander/Implant–Based Breast Reconstruction

Capsular contracture in implant based breast reconstruction—the effect of porcine acellular dermal matrix

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