The effect of alpha lipoic acid supplementation on sperm functions in idiopathic asthenozoospermic patients: a case-controlled study

Hodeeb, Yahya M.; Elrewiny, Emad M.; Gaafar, Abdullah; Zayed, Ahmed N.; Hasan, Mohamed S; Elsaie, Mohamed L.

doi:10.1080/14647273.2021.2025271

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…ALA can work equally well in fat-soluble or water-soluble states, intracellular or extracellular media, which is different from other antioxidants that only work in one of the conditions, provide a broader antioxidant activity (broad spectrum) to reduce the adverse effects of ROS. ALA also plays a role by participating in the production of other antioxidants such as glutathione and the regulation of adenosine triphosphate (ATP) [ 23 ]. A shield, which is actively produced by ALA over the sperm midpiece through interrelation with glutathione and ascorbic acid, protects the inner organelles from ROS induced by free radicals [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of oral alpha-lipoic acid (ALA) on sperm parameters: a systematic review and meta-analysis

Dong

Yang

et al. 2022

Basic Clin. Androl.

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Background Male fertility has gradually become a worldwide problem with limitations in the treatment. Alpha-lipoic acid, has been applied to improve the quality of sperm in clinical practice. However, there was currently no high quality of systematic review to evaluate the effects of alpha-lipoic acid on sperm parameters. Material and methods The Cochrane Library, MEDLINE, EMBASE, Web of Science, Clinicaltrials.org, China National Knowledge Infrastructure Database, China Biology Medicine Database, etc., were retrieved. Related randomized controlled trials had be collected and selected up to March 10, 2022. English literature and Chinese literature were searched using terms including “male infertility”, “semen”, “sperm”, “alpha-lipoid acid”, “α-lipoid acid”, “alpha lipoid acid”, “thioctic acid”. All statistical analyses were conducted by RevMan 5.3. Results A total of 133 participants in three studies included. Compared with sham therapy, treated with alpha-lipoic acid has significant improvement in the following sperm parameters, including abnormal sperm forms (mean difference[MD] = -1.06, 95% confidence interval [CI] = -1.29–0.84, p < 0.00001), sperm concentration (MD = 3.98, 95%CI = 2.28–5.67, p < 0.00001), sperm total motility (grade a+b+c) (MD = 6.68, 95%CI = 4.88–8.48, p < 0.00001) and progressive motility(grade a+b) (MD = 6.90, 95%CI = 5.62–8.17, p < 0.00001) and semen volume(MD = -0.17, 95%CI = -0.31–0.02, p = 0.03). Conclusions In this meta-analysis of three randomized controlled trials, compared with other treatments, alpha-lipoic acid could improve normal sperm forms, sperm concentration, sperm total motility and progressive motility, but more stringent randomized controlled trials must be conducted.

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Section: Discussionmentioning

confidence: 99%

“…In addition, another study, Hodeeb 2022 [ 23 ], was retrieved this time. Because this was an observational study and did not belong to RCT, it could not be included in this meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

Effect of oral alpha-lipoic acid (ALA) on sperm parameters: a systematic review and meta-analysis

Dong

Yang

et al. 2022

Basic Clin. Androl.

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Potential for Novel Therapeutic Uses of Alpha Lipoic Acid

Fasipe

Faria

Laher

2023

CMC

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Alpha-lipoic acid (ALA) is a potent antioxidant used in the management of diabetic neuropathy due to its ability to prevent neuronal lipid peroxidation. ALA also chelates transition metals, which can be beneficial in some diseases related to metal overload. Because of its unique antioxidant properties, ALA has potential novel applications in other diseases related to oxidative stress and inflammation. This review summarizes aspects of recent clinical trials in addition to the well described uses to manage neuropathies. The unique pharmacological actions of ALA, coupled with a relatively low toxicity, has other led to several trials on the potential therapeutic uses of ALA in the management of other diseases associated with increases in oxidative stress, inflammation and metal overload.

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Alpha-Lipoic Acid: Biological Mechanisms and Health Benefits

Superti,

Russo

2024

Antioxidants

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Alpha-lipoic acid (ALA) is a bioactive molecule with significant health effects. The biological action of ALA has been ascribed to the characteristic antioxidant properties of the oxidized form (ALA) and its reduced counterpart the dihydrolipoic acid (DHLA) system. The ALA/DHLA combination represents an ideal antioxidant since it can quench radicals, is able to chelate metals, is amphiphilic, and has no major adverse effects. This unique system is able to scavenge reactive oxygen species, exerting a major effect on tissue levels of reduced forms of other antioxidants, including glutathione. For this reason, ALA is also known as the “antioxidant of antioxidants”. This review analyzes the antioxidant, anti-inflammatory, and neuroprotective effects of ALA and discusses its applications as an ameliorative tool for chronic diseases and those associated with oxidative stress. Results from in vitro and in vivo studies demonstrated that ALA modulates various oxidative stress pathways suggesting its application, alone or in combination with other functional substances, as a useful support in numerous conditions, in which the balance oxidant–antioxidant is disrupted, such as neurodegenerative disorders. Based on several successful clinical studies, it has been also established that oral ALA supplements are clinically useful in relieving the complications of diabetes and other disorders including cardiovascular diseases and nerve discomforts suggesting that ALA can be considered a useful approach to improving our health.

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The effect of alpha lipoic acid supplementation on sperm functions in idiopathic asthenozoospermic patients: a case-controlled study

Cited by 3 publications

References 23 publications

Effect of oral alpha-lipoic acid (ALA) on sperm parameters: a systematic review and meta-analysis

Effect of oral alpha-lipoic acid (ALA) on sperm parameters: a systematic review and meta-analysis

Potential for Novel Therapeutic Uses of Alpha Lipoic Acid

Alpha-Lipoic Acid: Biological Mechanisms and Health Benefits

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